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Identification of social and psychological causes of juvenile delinquency: a case study of rawalpindi adiala jail

Thesis Info

Author

Maryam Zahra

Department

Department of Sociology

Program

MS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Sociology

Language

English

Other

MA/MSc 301 MAI

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676722910250

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محمد اقبال منہاس

محمد اقبال منہاس(۱۹۴۱ء۔۱۹۹۰ء) نام اور اقبالؔ تخلص کرتے تھے۔ آپ کے آباؤ اجداد کا تعلق پسرور سے تھا۔ آپ کے والد ملازمت کے سلسلے میں عراق میں مقیم تھے۔ جہاں اقبال منہاس پیدا ہوئے۔ آپ نے انٹر سے ایم ۔انگلش تک تعلیم گورنمنٹ مرے کالج سیالکوٹ سے حاصل کی۔ انھوں نے انگریزی ادب میں ڈاکٹریٹ کی ڈگری بھی حاصل کی ۔آپ دوران طالب علمی’’ مرے کالج میگزین ‘‘کے حصہ اردو کے مدیر بھی رہے۔ اور اسی کالج میں بحیثیت استاد بھی کام کیا۔ (۹۶۵) منہاس کے علمی و ادبی ،تحقیقی و تنقیدی مضامین اور غزلیں ’’شمع‘‘ ،دہلی ،’’سیپ‘‘، ’’فنون‘‘ ،’’اوراق‘‘،’’افکار‘‘ اور ’’رابطہ‘‘ میں شائع ہو چکی ہیں۔ آپ کا ایک شعری مجموعہ ’’آبِ گریزاں‘‘ شائع ہو چکا ہے جسے معروف شاعر طاہر نظامی نے مرتب کیا ہے۔ ’’آب گریزاں‘‘ میں نظمیں ،غزلیں ،قطعات اور رباعیات شامل ہیں۔

اقبال منہاس کی شاعری کے لہجے میں نیا پن پایا جاتا ہے۔ ان کے ہاں موضوعات کی جدت، جدید حسیات اور نئی لفظیات ملتی ہیں:

وہ لوگ پھول سے کومل وجود رکھتے ہیں

 

وہ جن کے دامن رنگین میں خار ہوتے ہیں

 

شمع جلے نہ کوئی پھول ہی کھلے جن پر

 

وہی تو اہلِ وفا کے مزار ہوتے ہیں

(۹۶۶)

áاقبالؔ ایک حساس شاعر اور حساس انسان ہیں ۔ وہ عام انسانوں کے مقابلے میں معاشرہ میں ہونیوالی نا انصافیوں اور استحصال کو جلد محسوس کرتے ہیں۔ اقبال منہاس اپنے ارد گرد ظلم ، معاشی و سماجی نا ہمواری اور انسانی بے بسی کو دیکھتے ہیں تو خاموش تماشائی نہیں بنتے۔ ان کی شخصیت اور شاعری میں ایک محتاط رویہ بھی ملتا ہے۔ اور...

یاجوج ماجوج: جدید تعبیرات اور معاصر اقوام پر اطلاق و انطباق: ایک تجزیاتی مطالعہ

Gog and Magog Interpretations by Modern Scholars and its Application on Contemporary Nations: An Analytical Study According to the Islamic point of view Gog and Magog (Ya’jūj Ma’jūj), are two such supernatural and aggressive powers that will reveal from some unknown place. According to Islamic sources the two disbelieving powers (tribes) are the children of Yāfith son of Noah. Humanity will affect badly at their severely harmful activities on the earth. In the beginning they were free into some unknown place. The famous king Dhulqarnayn imprisoned them behind an unknown thick wall in human history. There are many conjectures regarding the wall, and it is sometimes considered in any Norwegian country because of too long duration of sunrise in these countries. Their population will be 10 times more than the World’s populations. They will be so much trouble creating nation from the race of Noah (A.S) even Isa (Christ) will take refuge on the mountain of Toor and Muslims will pray Allah to get rid of them. Today some modern Islamic researchers have been claiming that they are in fact, Chines or Russians as we find their resemblance in prophet's traditions. In this article, an attempt has been made to unveil the disputed matter that either they exist in current age in form of living peoples or some hidden which will be revealed before the end of time. The purpose of this research is to revisit different speculations about Gog and Magog as we find them also into the Bible. Many Muslims research took effect from Bible’s concept ignoring the traditions of the prophet and find out many different solutions which, according to me are to be seen into the true and clear facts by Quran and Sunnah.

Synthesis, Structural Analysis and Pharmaceutical Screening of S-Substituted Derivatives of 1, 3, 4- Oxadiazole-2-Thiol and 1, 2, 4-Triazole-3-Thiol Having 4-Methylphenyl Sulfonyl Piperidine

Heterocyclic compounds are being focused by the organic and synthetic chemists because of their wide range of biological and other desirable applications. Five membered heterocyclic moieties, oxadiazoles and triazoles are among the most considered five membered heterocyclic cores for the production of new potential synthetic drugs. The most studied isomers of these heterocyclic moieties are 1,3,4- oxadiazole and 1,2,4-triazole owing to their potent pharmaceutical activities. Keeping in view the importance of 1,3,4-oxadiazole and 1,2,4-triazole heterocycles, a number of different S-substituted derivatives of 1,3,4-oxadiazole-2- thiol and 1,2,4-triazole-3-thiol having 4-methylphenyl sulfonyl piperidine have been synthesized and screened for the evaluation of pharmaceutical potential including antibacterial and enzyme inhibition. The antibacterial potential was evaluated against certain strains of Gram positive and Gram negative bacteria. Enzyme inhibition potential was evaluated against lipoxygenase (LOX) enzyme responsible for inflammation. The list of ninety seven (97) synthesized derivatives includes fifty seven (57) derivatives of 1,3,4-oxadiazole (7a-w, 11a-v, 14a-l) and forty (40) derivatives of 1,2,4-triazole (18a-t, 19a-t). The multistep protocols for all of these compounds have been described in five (5) schemes. The compound ethyl 1-tosylpiperidine-4- carboxylate (3) was synthesized by the reaction of 4-methylphenyl sulfonyl chloride (1) and ethyl isonipecotate (2) using 10% aqueous solution of Na2CO3 as reaction medium. The compound 3 was further converted into corresponding carbohydrazide (4) by hydrated hydrazine in methanol under reflux. 5-(1-(4-Methylphenylsulfonyl) piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5) was synthesized from compound (4) by reflux in ethanol in the presence of carbon disulfide (CS2) in basic medium. Twenty three (23) alkyl/aralkyl derivatives of 1,3,4-oxadiazole-2-thiol having 4-methylphenyl sulfonyl piperidine were synthesized (7a-w, Scheme-1) by the reaction of 5 and 6a-w. N-Substituted alkyl/aralkyl amines (8a-v) were made to react with 2-bromoacetyl bromide (9) to synthesize 2-bromo-N-substituted acetamides (10a-v) as electrophiles. The synthesized 1,3,4-oxadiazole-2-thiol (5) was further derivatized by these electrophiles (10a-v) to synthesize twenty two (22) N-substituted acetamide derivatives (11a-v, Scheme-2). N-substituted alkyl/aralkyl amines (8a-g,j,m,n,p,v) were made to react with 3-bromopropionyl bromide (12) to synthesize 3-bromo-Nsubstituted propanamides (13a-l). Again the synthesized 1,3,4-oxadiazole-2-thiol (5) was derivatized with these electrophiles (13a-l) to synthesize twelve (12) Nsubstituted propanamides (14a-l, Scheme-3). Compound 4 was refluxed with isothiocyanatobenzene (15) in methanol to produce N-phenyl-2-(1-4- methylphenylsulfonylpiperidine-4-carbonyl)hydrazine carbothioamide (16). The compound 16 was cyclized to 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3- thiol (17) using 10% aqueous solution of NaOH as reaction medium. The synthesized 1,2,4-triazole-3-thiol (17) was used to produce twenty (20) derivatives (18a-t, Scheme-4) on reaction with different alkyl/aralkyl halides (6a-t) in a polar aprotic medium. The synthesized electrophiles, 2-bromo-N-substituted acetamides (10a-s,u), were stirred with the synthesized 1,2,4-triazole-3-thiol (17) to yield twenty (20) different N-substituted acetamide derivatives (19a-t, Scheme-5). Structures of all the synthesized compounds were confirmed using Infra Red (IR) spectroscopy, Proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy, Carbon-13 Nuclear Magnetic Resonance (13C-NMR) spectroscopy and Electron Impact Mass Spectrometry (EIMS) data. Ring formation of 1,3,4-oxadiazole and 1,2,4-triazole was confirmed through 13C-NMR. The determined physical data of all the target compounds includes physical state, color, yield, melting point, molecular formula and molecular mass which are given in results section (Chapter-4). The synthesized compounds were screened for antimicrobial potential against Gram-positive and Gram-negative bacterial strains. The results of antibacterial potential are given as % inhibition and minimum inhibitory concentration (MIC) values. Among the alkyl/aralkyl S-substituted derivatives (7a-w) of 5-(1-(4-methyl phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), compounds 7a, 7c and 7m remained the most active against P. aeruginosa, S. aureus and E. coli respectively and compound 7o against both of S. typhi and B. subtilis. All of these (7a, 7c, 7m, 7o) showed antibacterial activity comparable to that of the reference standard, Ciprofloxacin. Among the acetamide derivatives (11a-v) of 5-(1-(4- methylphenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), compounds 11c and 11s exhibited proficient activity against S. typhi and P. aeruginosa, respectively and compound 11d against three strains including E. coli, S. aureus and B. subtilis. These three most active compounds also showed activity comparable to that of Ciprofloxacin. Among the propanamide derivatives (14a-l) of 5-(1-(4- methylphenylsulfonyl) piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), compounds 14b showed efficient activity against B. subtilis and P. aeruginosa; compounds 14d, 14f and 14g against E. coli, S. aureus and S. typhi, respectively and also comparable to that of Ciprofloxacin. Among the alkyl/aralkyl S-substituted derivatives (18a-t) of 4- phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (17), compound 18a executed better potential against four bacterial strains S. typhi, E. coli, B. subtilis and P. aeruginosa and 18c against S. aureus. The observed potential was also comparable to the reference. Among the acetamide derivatives (19a-t) of 4-phenyl-5-(1- tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (17), the most active compounds were 19a against S. typhi, 19d against E. coli, 19o against B. subtilis and 19h against P. aeruginosa with MIC value close to that of the reference. Lipoxygenase (LOX) inhibition potential was evaluated with reference to Baicalein, the reference standard. The enzyme inhibition activity results are given as % inhibition and concentration for 50% inhibition (IC50) values. Among the alkyl/aralkyl S-substituted derivatives (7a-w) of 5-(1-(4-methyl phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), three the most potent inhibitors of LOX were 7a, 7b and 7c with reference of the standard, Baicalein. Among the acetamide derivatives (11a-v) of 5-(1-(4-methylphenylsulfonyl)piperidin- 4-yl)-1,3,4-oxadiazole-2-thiol (5), three the most potent inhibitors of LOX were 11m, 11n and 11t. Among the propionamide derivatives (14a-l) of 5-(1-(4- methylphenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), two the most potent inhibitors of LOX were 14e and 14f. Among the alkyl/aralkyl S-substituted derivatives (18a-t) of 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (17), three the most potent inhibitors of LOX were 18a, 18b and 18c. Among the acetamide derivatives (19a-t) of 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole- 3-thiol (17), three the most potent inhibitors of LOX were 19g, 19n and 19r. The activity of all these compounds was compared to the reference, Baicalein. Furthermore, the molecular docking studies have been discussed in Chapter-4 for LOX inhibition activity. Overall a number of compounds exhibited moderate LOX inhibition potential as compared to reference standard, Baicalein. Many compounds showed excellent antibacterial potential. The most active compounds against bacterial strains might be suitable as new drug candidates in pharmaceutical industries to develop potent drugs for the different bacterial infection. The most active LOX inhibitors might be further forwarded as new drug candidates for inflammatory diseases.