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Thesis Info

Author

Muhammad Haseeb Anwar

Department

Department of Technology Management

Program

MBA

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2002

Thesis Completion Status

Completed

Subject

Technology Management

Language

English

Other

MA/MSc 004.62 ANW

Added

2021-02-17 19:49:13

Modified

2023-01-08 08:32:12

ARI ID

1676723172832

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سید صادقؔ حسین

سید صادقؔ حسین (۱۸۹۸۔۱۹۸۹ء) نام اور صادقؔ تخلص کرتے تھے۔ آپ کھادڑ پاڑہ (کشمیر) میں پیدا ہوئے۔ آپ کے والدین نے کشمیر سے ہجرت کر کے شکر گڑھ (سیالکوٹ) میں سکونت اختیار کی۔ آپ کے والد صفدر کاظمی نے وفاقی سیکرٹری کے عہدے پر کام کیا۔ تعلیم مکمل کرنے کے بعد آپ نے ظفر وال سے وکالت کا آغاز کیا۔ آپ تحریکِ پاکستان میں کارکن کے طور پر کام کرتے رہے۔ ۱۹۳۶ء میں آپ صدر مسلم لیگ شکر گڑھ مقرر ہوئے۔ آپ کا واحد شعری مجموعہ ’’برگِ سبز‘‘ کے نام سے شائع ہوا۔ (۲۷۶)

صادق کو صرف ایک شعر کی وجہ سے اردو شاعر ی میں شہرت ملی۔ بعض حضرات اس شعر کو علامہ محمد اقبال سے منسوب کرتے ہیں۔ یہ شعر ان کے شعری مجموعے ’’برگ سبز‘‘ کی ایک غزل میں موجود ہے۔ شعر ملاحظہ ہو:

تندیٔ بادِ مخالف سے نہ گھبرا اے عقاب                       یہ تو چلتی ہے تجھے اونچا اڑانے کے لیے          (۲۷۷)

صادقؔ نظم اور غزل کے شاعر ہیں۔ نظم پر اقبال کے اثرات ہیں اور غزل میں روایت کی جھلک نظر آتی ہے۔ ان کی شاعری میں قرآن مجید کے منظوم تراجم بھی موجود ہیں۔ انہیں اسلام سے سچی محبت ہے۔ اس محبت کا اظہار وہ خدائے بزرگ و برتر کی حمد و ثنا سے کرتے ہیں۔ وہ قرآن پاک کا ترجمہ کرتے ہوئے عام فہم اور سادہ زبان استعمال کرتے ہیں۔ ان کا اسلوب اتنا اچھا ہے کہ وہ ترجمہ معلوم نہیں ہوتا۔ سورت فاتحہ کی کچھ آیات کا منظوم ترجمہ ملاحظہ ہو:

خداوندِ جہاں تیرے لئے تعریف ہے ساری                 کہ ہے لطف و کرم تیرا ہر انس و جان پر جاری               

تو ہی ہے مالک و مختارِ کل روزِ قیامت کا                           ہر اک ہم میں سے دم بھرتا ہے تیری ہی عبادت کا       

تری ہی...

مرزا بیدل: شاعر اخلاق

Mirza Bedil is a famous and well renowned poet of his era and after his era. His poetry has very poetically and lyrically characteristics, thoughts of his poetry also influenced on Urdu and Persian language. Even big poets of Urdu and Persian Ghalib and Iqbal inspired by Bedil’s poetry style and thoughts. Bedil’s poetry has many ethically manners, mystically thoughts, secrets of life and also thoughts of life’s movement to forward. In this article must present the ethically and good manners aspects of Bedil’s poetry, according to life, mystic, God, earth and other aspects of daily life.

Studies on Bioactivity of Some Compounds of Plant Origin

Recurrence of old diseases and emergence of new diseases demands for availability of effective therapeutic agents of higher therapeutic index. Plants are considered as rich source of therapeutic agents. The history of herbology is intertwined with that of modern medicine. Herbal treatment is useful for both acute and chronic conditions including AIDS, cancer and diabetes. Contemporary studies clearly demonstrate that plants are very rich source of novel antimicrobial and immunomodulatory substances. In the present study 370 natural substances (pure compounds, extracts, fraction and aromatic acids) isolated from various part of the twenty medicinally important plants, including Polyalthia longifolia, Holarrhena pubescens, Tagetes patula, Tagetes erecta, Eucalyptus camaldulensis Morinda citrifolia Datura innoxia, Azadirachta indica, Melia azedarach, Psidium guajava, Syzygium aromaticum, Lantana camara, and others, were screened for biological potentials. These plant samples were obtained from H.E.J. Research Institute of Chemistry. Antimicrobial activity of these compounds was determined against thirty five bacterial and fourteen fungal strains by disc diffusion method. Highest activity was observed in plant S. aromaticum (clove) where all the extracts exhibited antimicrobial activity against all the organisms (bacteria and fungi) tested with MIC value (0.78-100 μg/disc). These extracts were more potent against Micrococcus luteus ATCC 9341, Bacillus cereus ATCC 11778, Bacillus subtilis and Bacillus thuringiensis as compare to ampicillin and streptomycin used as a control. Similarly compounds from P. longifolia var. pendula, exhibited excellent activity against Gram positive bacteria and fungi with MIC 0.39-100 μg/disc. Few extracts, their fractions and pure compounds from root, stem and berries exhibited excellent anti-MRSA activity with MIC 0.39-3.12 μg/disc. Compounds isolated from berries also exhibited good anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv (MIC 6.25 -100 μg/disc). Few extracts from D. innoxia, H. pubescens, M. citrifolia and some aromatic acids from M. azederah exhibited good activity against Gram positive bacteria and dermatophytes tested. However, rest of the plants extracts showed variable activity (low to moderate) against different organisms (bacteria and fungi), while very few of them were active against Gram negative bacteria. Immunomodulatory activity of 24 selected compounds was studied on superoxide production using chemiluminescence assay; and T lymphocytes proliferation by radio labeled Thymidine incorporation method. Diterpenes isolated from root bark of P. longifolia var. Pendula; Hydroquinone, its derivative; 1,3- Dimethoxy anthraquinone from fruits of M. citrifolia; Patuletin from T. patula, Lantanilic acid from L. camara and (Hp. Bases) methanolic extract of H. pubescens exhibited significant inhibitory effect against the production of superoxide by whole blood, PMN, MN and Macrophages (p<0.005 - p<0.0005). All these compounds/extract were found more potent than ibuprofen. Hydroquinone from M. citrifolia; Patuletin from T. patula; fractions/pure compounds of P. longifolia; Lantanolic acid from L. camara and Ursolic acid lactone from E. camaldulensis, inhibited T-cells proliferation. Hydroquinone and diterpene 4(18), 12E-Clerodadien-15, 16-N [4’ (18’), 13’ (16’) E-clerodadien- 15’-oic acid] imide were found more potent than prednisolone (P<0.005, P<0.0005 respectively). Lantanolic acid, Lantanilic acid, Ursolic acid lactone, Anithol, pure compounds from P. longifolia var. pendula (PGM-2EA, PBBM-2EA, PSBM2EA, 3PC, 36PM, 72PM, 16+18, fractions 6EA, 6a+b) and extracts from H. pubescens and T. patula exhibited significant stimulatory effect at their lower concentration (0.78 -6.25 μg/ml) against the production of superoxide by whole blood, PMN, MN and Macrophages. All these compounds also stimulated the production of T-cells in T-cell proliferation assay. Some of the above compounds, showing excellent activity, could be considered as an important agent for developing new antimicrobials as well as immunomodulatory agents. However, further investigation is required, for determining the mode of action of the bioactive principle present in these compounds/ extracts, before recommending these compounds in the list of therapeutic agents.