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Association of tumor suppressor Gene P53 with Lung Cancer in Pakistani Population

Thesis Info

Author

Syeda Uzma Ali

Department

Department of Bioinformatics and Biotechnology

Program

BS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2009

Thesis Completion Status

Completed

Subject

Bioinformatics & Biotechnology

Language

English

Other

BS 616.99424 ALA

Added

2021-02-17 19:49:13

Modified

2023-01-07 23:15:31

ARI ID

1676723218086

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مولانا قاری محمد طیب

موت العالمِ موت العالَم
وادریغا!دودمان قاسمی کالعل شب چراغ گم ہوگیا۔چمن زار دارالعلوم دیوبند کا گل سرسبد مرگ کی باد صرصر سے نذرخزاں ہوگیا،بزم علم وعرفان کی شمع فروزاں بجھ گئی،حسن بیان وخطابت کے ایوان میں زلزلہ آگیا،مسند وعظ ومصطبۂ ارشاد وہدایت بے رونق ہوگئے، یعنی ۱۷/جولائی کوحضرت مولانا قاری محمد طیب صاحب کم وبیش۸۸برس کی عمر میں عالم آب وگل کوخیرآباد کہہ کر عالم آخرت کی طرف منتقل ہوگئے۔اناﷲ واناالیہ راجعون۔ شب میں عشاء کی نمازکے بعد ہزاروں ماتم گساروں کے مجمع میں نمازجنازہ دارالعلوم کے احاطۂ مولسری میں ادا کی گئی اورپھرتدفین جدامجد نوراﷲ مرقدہ کے پہلو میں ہوئی، اس طرح گویا:
پہنچی وہیں پہ خاک کہ جس کاخمیر تھی
کل من علیہا فانoویبقیٰ وجہ ربک ذوالجلال والاکرام۔
حضرت مرحوم جب پیداہوئے، یہ دارالعلوم دیوبند کے اوج شباب کا زمانہ تھا۔ اساتذہ کرام اپنے اپنے فن میں یگانۂ روزگار تھے جن کے علم وفضل اور مہارت فن کا آوازہ ممالک غیر میں بھی دور دور تک پہنچا ہواتھا۔پھر اس دور کی ایک بڑی اوراہم خصوصیت یہ تھی کہ اصحاب درس وتدریس خود بھی روحانی اور باطنی کمالات کے حامل اورجامع ہوتے تھے، اوران کے علاوہ تھانہ بھون، سہارنپور اور دیوبند میں مستقل طورپرطریقت ومعرفت کی درس گاہیں قائم تھیں اور دارالعلوم جس کانام تھا وہ درحقیقت انہی دونوں قسم کے علوم وفنون کی تعلیم وتربیت گاہ تھا، غرض کہ ایک طرف یہ سرچشمہ ہائے فیض تھے جوپوری آب وتاب کے ساتھ رواں دواں تھے اوردوسری جانب حضرت مرحوم خانوادۂ قاسمی کے چشم و چراغ ہونے کے باعث ہرایک کے نور نظر اورلخت جگر تھے اورخود بھی ذاتی طورپر نہایت ذہین اور طباع، روشن ضمیر و نکتہ رس تھے اورطلب علم کاجوہر فطری رکھتے تھے، پھر کسر کس بات کی تھی، جوان ہوئے توحافظ قرآن اورقاری خوش الحان ہونے کے ساتھ ایک پختہ استعداد کے بالغ...

Conditions and Qualification for Being a Judge in the Light of the Islamic Law

‘Adl and Qisṭ is indeed a manifestation of God’s mercy, rather, it may also be seen as a principal objective of Shariʿah. The origin or sources of administration of justice in Islām are the Quran, Sunnah of the holy Prophet, consensus of opinions of the jurists of Islamic jurisprudence and Analogy (Qiyās). Justice is a sacred obligation of supererogatory. It is obligatory upon the Muslim rulers to appoint judges for the dispensation of justice to attain equality, to protect the human rights from their violation, to safeguard the lives and properties, and to maintain law and order in society. As a judge is supposed to accomplish a very important and noble task being a regent of Allāh, hence, some vital merits and criteria regarding the conditions and qualifications for the appointment of the Qāḍī or judge in the light of the Qur’ān, Sunnah and Islamic jurisprudence and the code of conduct for the Pakistani judges must be observed at all costs. The author of this paper has discussed these conditions and qualifications in this article. There are some unanimous conditions for the appointment of judges, while some others are not agreed upon. While presenting the difference of opinions of the Islamic jurists, the author tried to explain, reconcile the opinions and at some places presented her own view in the light of her analysis and arguments. These conditions are around thirty, but the author according to her own discretion chose some of the most important ones to discuss in this paper.

Biodiversity in Pears Pyrus Spp. : Characterization and Conservation of Germplasm from Azad Jammu and Kashmir

A survey of five pear growing districts of Azad Jammu and Kashmir i.e. Rawalakot, Bagh, Muzaffarabad, Sudhnoti and Kotli was conducted during the year 2003 and 60 accessions of distinct characters of horticultural importance were selected from 48 sites of these districts for characterization. For each accession, passport data were collected with the help of Pyrus descriptor as developed by International Board of Plant Genetic Resources. During the next two years (2004 and 2005), all the selected accessions were visited thrice each year at the time of flowering, fruit setting and fruit maturity. Data were recorded on growth habit of plants, incidence of diseases (fire blight and apple scab), precocity, intensity of flowering, fruit setting, productivity, time of ripening, fruit shape and fruit colour. Leaves and fruit of these accessions were also collected and leaf area, fruit size and fruit weight were measured. Ripe fruit were evaluated for organoleptic parameters, nutritional value (TSS, total sugars and vitamin C content) and postharvest life at ordinary room temperature (26 ± 2 oC). The accessions differed for these parameters; however, the accessions with the same local name had almost similar characteristics. All the accessions locally called as Frashishi and Desi nashpati had the excellent fruit quality and can be exploited for commercial production in the area. Most of the other accessions, also had good fruit quality except few (locally called as Btangi, Btung, Raj btung and Pathar nakh), which are mostly used as rootstocks in the area. The accessions were characterized by using protein markers based on bio-chemical analysis (SDS-PAGE). The accessions differed in number of bands which ranged from 12- 20. According to the banding pattern the accessions were divided into the various groups and sub-groups showing similarities and differences among them. Out of sixty local xxaccessions, fifty six accessions along with eight varieties (used as reference control) were also characterized using DNA based SSR markers to assess genetic diversity and relationship among them. Nine out of 12 primers revealed clear and reproducible amplification banding pattern in 41 genotypes (33 accessions and 8 control varieties). Cluster analysis based on UPGMA dendrogram, grouped the genotypes into clusters sub- clusters and groups on the basis of relatedness and variability. Most of the accessions were absolutely homogenous and were classified into two homogenous groups, despite the fact that these accessions differed in there morphological and physico-chemical traits. Attempts were also made to preserve the local pear germplasm through in vivo and in vitro methods. For in vivo preservation, a nursery was established and nine pear genotypes i.e. Khurolli, Bagugisha, Pathar nakh, Desi nakh, Kotharnul, Desi nash, Frashishi, Kashmiri nakh and Raj btung were propagated through whip grafting on Btangi seedlings. The genotypes differed for growth parameters. Apical shoots of nine pear genotypes (already mentioned above except Desi nash but including Btangi) were preserved in vitro under minimal growth conditions using low temperature treatments, modification in medium strength and adding mannitol in the basal medium and also by reducing the concentration of BAP and using growth retardants for different storage periods i.e. 3, 6, 9 and 12 months. The genotype differed significantly for survival and regeneration percentages. Storage at 5 °C, MS medium containing 2.5% mannitol and MS medium with reduced concentration of BAP (0.50 mg l -1 ) were found significantly better as compared to other treatments. Storage for the minimum period (3 months) was better than other storage periods as assessed on the basis of survival and regenerability of the cultures.