E-Commerce and its Effects in Supply Chain Management

E-Commerce in today’s world is playing an important role in global business. A quantitative and quantitative research was conducted with professional members, employees working in organization which are dealing with E-Business or online working via internet and their views gave an empirical and dynamic approach to make business efficient and effective. Connectivity with market to find best manufacture for goods and for manufacture to finds its buyer for their finished goods. Flow of information become faster and gathering of data become easier to make activities of business to get optimal results. Numbers of goods are available complications to finds goods are removed by complimentary goods. Supplies of goods at proper time in order to meet demand by consumer plays win to win game. Improved methods of technology like RFID make work easier and accessible information about goods to management. Manpower in forms of labor is reducing which leads to decrease in the cost of goods. Ordering cost saves time and gives a specified time both producers to make commodity and consumer for delivery of goods. E-Commerce with contrast of components of supply chain in the form of ware house, logistics, number of listing suppliers, number of listing items on one web in the form of website on one platform give dynamic image to businesses in the race of competitive world. Business transactions done with internet not only reduce time but also make documents or records for longer time able to send data from distant parts of the world. Through websites we can get completive price information and other relevant information for goods.

Neuropharmacological Studies in Rat Models on Morphine and Nalbuphine Induced Addiction, Anti-Nociception and Serotonin-1A Receptor Expression for Improving Therapeutics in Pain

Morphine and other opioids are the most effective prescription medications for the treatment of pain. Associated addiction and hyperalgesia, however, limits the clinical utility of these drugs. The present study aimed to determine the potential effectiveness of buspirone, a partial agonist at 5-hydroxytryptamine (5-HT, serotonin)-1A receptor in reducing morphine-induced addiction and hyperalgesia. We found that co-administration of buspirone with morphine inhibited reinforcing as well as hyperalgesic effects of morphine. Tolerance in motor depressant effects of morphine was also reversed. Effects of morphine on dopamine and serotonin metabolism in nucleus accumbens and caudate were also reversed by buspirone co-administration. Reinforcing, analgesic, and motor effects of nalbuphine, another opioid drug, were also monitored. Both low and high doses of nalbuphine produced reinforcing effects. High but not low doses produced sensitization. Moderate doses of nalbuphine did not produce reinforcement or sensitization like effects. Moderate doses of nalbuphine produced greater pain killing effects than smaller or higher doses. We also determined the effects of repeated administration of buspirone on memory, pain perception, and 5-HT1A receptor expression in brain regions associated with addiction and memory. Administration of buspirone at 1 mg/kg but not at 0.3 mg/kg or 0.1 mg/kg produced significant analgesic effects. Repeated administration of buspirone at doses of 0.1 and 1 mg/kg but not at 0.3 mg/kg produced hyperalgesia. Low buspirone dosage (0.1 mg/kg) improved, while higher dosages (0.3 and 1 mg/kg) impaired performance in Morris water maze. This was associated with the down-regulation of serotonin-1A receptors in the prefrontal cortex and hippocampus. The findings show an important role of 5-HT1A receptor in morphine abuse and hyperalgesia. It is suggested that clinicians should consider buspirone as adjunctive therapy with morphine to prevent its abuse during the treatment. Because higher but not lower doses of buspirone were found to impair cognition; lower doses may be preferably used to improve therapeutics in chronic pain.