Search or add a thesis

Advanced Search (Beta)
Home > Structure modeling and insilico mining and analysis of non synomous single nucleotide polymorphism of human transcription fator 7 like 2

Structure modeling and insilico mining and analysis of non synomous single nucleotide polymorphism of human transcription fator 7 like 2

Thesis Info

Author

Nabisha Farooq

Supervisor

Mamoona Mushtaq

Department

Department of Bioinformatics and Biotechnology

Program

BS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Page

vi, 59

Subject

Bioinformatics & Biotechnology

Language

English

Other

BS 572.8633 NAS

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676723666457

Similar


Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

سید صادقؔ حسین

سید صادقؔ حسین
سید صادقؔ حسین (۱۸۹۸۔۱۹۸۹ئ) نام اور صادقؔ تخلص کرتے تھے۔ آپ کھادڑ پاڑہ (کشمیر) میں پیدا ہوئے۔ آپ کے والدین نے کشمیر سے ہجرت کر کے شکر گڑھ (سیالکوٹ) میں سکونت اختیار کی۔ آپ کے والد صفدر کاظمی نے وفاقی سیکرٹری کے عہدے پر کام کیا۔ تعلیم مکمل کرنے کے بعد آپ نے ظفر وال سے وکالت کا آغاز کیا۔ آپ تحریکِ پاکستان میں کارکن کے طور پر کام کرتے رہے۔ ۱۹۳۶ء میں آپ صدر مسلم لیگ شکر گڑھ مقرر ہوئے۔ آپ کا واحد شعری مجموعہ ’’برگِ سبز‘‘ کے نام سے شائع ہوا۔ (۲۶۰)
صادق کو صرف ایک شعر کی وجہ سے اردو شاعر ی میں شہرت ملی۔ بعض حضرات اس شعر کو علامہ محمد اقبال سے منسوب کرتے ہیں۔ یہ شعر ان کے شعری مجموعے ’’برگ سبز‘‘ کی ایک غزل میں موجود ہے۔ شعر ملاحظہ ہو:
تندیٔ بادِ مخالف سے نہ گھبرا اے عقاب
یہ تو چلتی ہے تجھے اونچا اڑانے کے لیے (۲۶۱)
صادقؔ نظم اور غزل کے شاعر ہیں۔ نظم پر اقبال کے اثرات ہیں اور غزل میں روایت کی جھلک نظر آتی ہے۔ ان کی شاعری میں قرآن مجید کے منظوم تراجم بھی موجود ہیں۔ انہیں اسلام سے سچی محبت ہے۔ اس محبت کا اظہار وہ خدائے بزرگ و برتر کی حمد و ثنا سے کرتے ہیں۔ وہ قرآن پاک کا ترجمہ کرتے ہوئے عام فہم اور سادہ زبان استعمال کرتے ہیں۔ ان کا اسلوب اتنا اچھا ہے کہ وہ ترجمہ معلوم نہیں ہوتا۔ کچھ اشعار ملاحظہ ہوں:
خداوندِ جہاں تیرے لئے تعریف ہے ساری
کہ ہے لطف و کرم تیرا ہر انس و جان پر جاری
تو ہی ہے مالک و مختارِ کل روزِ قیامت کا
ہر اک ہم میں سے دم بھرتا ہے تیری ہی عبادت کا
تری ہی ذات سے ہوتے ہیں ہم امداد کے طالب
تو...

RESILIENCE AS A MEDIATOR IN RELATIONSHIP BETWEEN ANXIETY AND PERSONALITY AMONG PHYSIOTHERAPISTS-A CROSS-SECTIONAL STUDY

Background and Aims: The COVID-19 outbreak is the biggest global crisis in generations having severe and far-reaching repercussions for the health system, creating high prevalence of severe posttraumatic stress symptoms for physical therapists, highlighting the need for psychological help. Therefore, this study aimed to investigate how resilience functions as a mediator in the relationship between anxiety and personality among Karachi based physiotherapists.         Methodology: A cross-sectional study was conducted among physiotherapists of Karachi using a convenience sampling technique from August to December 2021. The data was collected using a 10-Item Personality Inventory, Brief Resilience Scale, and Hamilton Anxiety Rating Scale questionnaire. Results: Among 70 participants, the emotional stability trait (7.6±1.4) had higher mean values on the TIPI. On the HAM-A scale, 81.4% physiotherapists had moderate to severe anxiety followed by 15.7% mild to moderate anxiety whereas 92.9% were shown to have normal resilience. Despite all correlations being negligible, only the association between agreeableness and resilience was non-significantly higher (r=0.83). Conclusion: It was concluded that there was no association between the anxiety state and resilience among physiotherapists, although there was a non-significantly higher relationship between agreeableness and openness to experiences personality traits. A high prevalence of moderate to severe anxiety was noted while using a standard resilience strategy.

Kinetics of Biodegradation of Synthetic Dyes by Agaricus Species

Textile dyes have always been considered in the context of recalcitrant xenobiotics compounds in water and soil ecology. Present research work was focused on the bioremediation potential of Agaricus species to decolorize and to detoxify the different synthetic dyes and dye containing effluents. The purification, characterization, kinetics & thermodynamic studies of ligninolytic enzymes produced by the fungi during dye decolorization process, were also performed. Complete (100%) removal of NOVASOL Direct Black and 83.34 % Reactive Black by Agaricus bitorqus A66 & Agaricus bisporus A21 were attained by optimizing optimal conditions like media composition, pH, temperature, inoculum size, carbon and nitrogen supplements, metal ions, redox mediators and dye concentration. In the entire processes of optimization of decolorization lignin peroxidase (LiP) was the major enzyme with minor activities of MnP and laccase when the decolorization of Novasol black was carried out by Agaricus bitorqus A66 and manganese peroxidase (MnP) was the main enzyme with minor LiP and laccase activities in case of reactive black treated by Agaricus bisporus A21. As highly efficient decolorization (100%) of synthetic dye was attained by these Agaricus species in a reasonably short period of time under optimum conditions, these were therefore, applied to check out their potential application in the decolorization of different practical/real textile industry effluent. It was observed that complete (100%) and 95.66 % decolorization of Navy blue colored effluent was achieved by Agaricus bitorqus and Agaricus bisporus A21 , respectively under optimum conditions. To access the water quality parameters, the treated and untreated effluent samples were analyzed to determine COD, BOD, TSS and TDS. The fungal treated effluents were less polluted as compared to original industrial effluents. The enzymes (LiP & MnP) produced under optimum decolorization conditions were purified to 1.54 & 6.9 fold with % yield of 6.74 and 8.48, respectively by ammonium sulfate precipitation, followed by three purification steps including, Dialysis, gel-filtration and anion- exchange chromatography. MnP and LiP secreted by respective fungi displayed optimum activities pH 7.0 & 6.0 and at 45 &400C, respectively. The Km values for veratryl alcohol and MnSO4 were 16.67 mM, 3.33 mM for MnP and LiP, having Vmax values of 179.17 and 231.00 mM, respectively. Thermodynamic and activation parameters provide a detailed mechanism for many chemical and biological reactions. The kinetic and thermodynamic characterization revealed Gibbs free energy ΔG* values for denaturation of MnP and LiP as 272.12 & 272.6 KJmol-1, enthalpy of thermal unfolding ΔH* of transition state was 39.91& 72.83 KJmol-1 and entropy of thermal unfolding (ΔS*) was -707.94 &, -609 Jmol-1K-1 at 50oC along with activation energy for inactivation of Ea 42.6, 75.6 KJmol-1, respectively.