Cytotoxic Assessment of Quinoline Based Derivatives on Liver Cancer Cell Line Quinoline compounds and their Cytotoxicity

Current scenario of newer diseases with multiple causes has drawn the attention of the researchers in the field of therapeutics and they are now inclined to identify molecules effective for targeted therapy. Objective: Quinoline (1-azanaphthalene); belongs to heterocyclic aromatic nitrogen compound. Some quinoline-based derivatives are also known for their anti-tumor activity. The study was planned to evaluate the cytotoxic potential of quinoline derivatives. Methods: Berberine; a quinoline compound was made part of study to make structural analogs which were docked against potential target proteins. Cytotoxic profiling of all derivatives was done using MTT cytotoxicity assay. Results: The pharmacoinformatic and structure activity relationship studies of analogs were done. The cytotoxic profiles were elucidated by comparing viability rates of analogs treated hepatic cancerous cell line with untreated hepatic cells and untreated mesenchymal stem cells as standards.  Marked cytotoxicity was seen in all molecules at low doses than reported in past studies with relevance to parent compound. Conclusions: The results will be further confirmed through various other cell culture assays targeting different marker proteins, pharmacoinformatics tools and structure activity relationship studies

Leadership Behavior and Employee Job Satisfaction: A Study of Path Goal Theory in Telecom Sector

This study was designed to test the path-goal theory of leadership in Pakistan telecom (mobile) industry. The study explored relationship between leadership behaviors (directive, supportive, participative and achievement-oriented) of middle managers and job satisfaction of subordinates. Path-goal leadership model attempts to explain the impact of leader behavior on the subordinate motivation, satisfaction and performance. Leadership behaviors (directive, supportive, participative and achievement-oriented) of managers were measured through leader behavior items. Subordinates’ satisfaction was measured by the job descriptive index. While job expectancy I and job expectancy II were measured through job expectancy scale. The four path-goal leader behaviors, seven moderating variables and nine subordinates’ outcomes were measured through the instrument comprising of 189 items. Further, the results of study were obtained by testing 28 hypotheses. The analysis suggested that the moderating variables influence preference for a particular type of leadership behavior (by the subordinate) and leader behavior has an impact on subordinate satisfaction, job expectancy (I&II) and acceptance of leader. Leader behavior affects satisfaction directly. Further subordinate satisfaction has a direct effect on the subordinate performance which is further influenced by the task demand. There was no difference between male and female respondents regarding any dependent measure. Moreover, the direction of association between variables is not known and it is difficult to predict accurately without further research, which is replicated and revalidated. Due to time constraints, the research has several limitations. Recommendations are made for future study, particularly replication in the public and private sectors to ensure validity which will help in determining causal relationship between leader behavior and subordinate satisfaction.