ہر انسان کو اپنی اصلاح اور درستگی اور سیرت کی تعمیر پر توجہ دینی چاہیے اللہ تبارک و تعالیٰ سورۃ المائدہ میں ارشاد فرماتے ہیں:
"يٰـاَيُّهَا الَّذِينَ اٰمَنُوا عَلَيكُم اَنفُسَكُم لَا يَضُرُّكُم مَّن ضَلَّ اِذَا اهتَدَيتُم اِلَى اللّٰهِ مَرجِعُكُم جَمِيعًا فَيُـنَـبِّـئُكُم بِمَا كُنتُم تَعمَلُونَ "۔[[1]]
"اے ایمان والو، تم اپنی فکر رکھو، اگر تم ہدایت پر ہو تو جو گمراہ ہوا وہ تمہارا کچھ نہیں بگاڑے گا۔ اللہ ہی کی طرف تم سب کا پلٹنا ہے، وہ تمہیں بتائے گا جو کچھ تم کرتے رہے ہو"۔
"اس آیت میں بیان کیا گیا ہے کہ ہر وقت دوسروں کے اعمال کی برائیوں دوسروں کے عقائد کی خرابیوں پر نظر رکھنے کی بجائے خود اپنے افعال واعمال، کردار و سیرت، اخلاق اقوال ، افکار و خیالات کو خرابی اور برائی سے بچانے کی فکر وسعی ہونی چاہیے انسان کو ہمہ وقت اپنی ذات کا محاسبہ کرتے رہنا چاہیے کہ وہ خدا اور بندگان خدا کے حقوق کی ادائیگی کر رہا ہے یا نہیں یہ احساس اور فکر پیدا ہو جائے تو وہ کامیاب ہے۔ اس لیے صاحب عقل وہی ہے جو قوت و ضعف کے پہلوؤں کو فراموش اور نظر انداز نہ کرے وہ اپنی قوت ذہانت اور معلومات پر اکڑ نہ دکھائے اور اپنی برتری کا مدعی نہ ہو اور اس کا احساس برتری کی ضرورت کی حد تک نہ پہنچے اسی طرح وہ اپنی کمزوری بے بسی اور ناتوانی کے پیش نظر اپنے کو حقیر نہ سمجھیں اور اس کا احساس کمتری ناکامی کی حد تک اسے نہ پہنچائے افراد واقوام کی یہ بیماریاں ہوتی ہیں کہ یا تو ان کا احساس برتری کی انتہا تک پہنچ جاتا ہے یا ان کا احساس کمتری کا شکار ہو تو دل سے جا ملتا ہے کہ...
The government of General Ayub Khan (Former President of Pakistan) established an Institution in 1960, in the name of Idarah Tahqeeqat Islami (Islamic Research Institute). Dr, Fazlur Rahman, was the visiting professor at the institute remained on the rank of director of the year 1961 to 768 in seven years. And later, he serves as an advisor to the Islamic Ideology council. The writer who was published by the Institute of Islamic Research was the first editor of "Fikr-o - Nazar”. The scholars were considered as 'expertise of logic and philosophy' as 'interpretation of the Qur'an'. It is mentioned in the various verses of the Prophet (peace and blessings of Allah be upon him). The slaughtering of zakat in 'zakat' animal slaughtering 'basic laws and family planning' matters of marriage and Sunnah, such as the month of revelation, and their opinions have earned great reputation. And because of which they were accused of denying the heavenly nature of the Qur'an. Therefore, the first step towards Islamic thinking regarding the Islamic idea was to put an eye on Islamic law and religious beliefs on Islam. According to their plan, the difference between the Quranic verses and the verses and the laws of the law, is the difference. Regarding the meanings, his axis received: The beginning of the tradition and the meaning of 'the law of the law' is the word and the law. Islamic Laws' Principles Concernedly speaking about issues like Fiqh and Qa'as and al-Azai speak.
Herein we reports the synthesis of new mono and diorganotin(IV) complexes of Schiff baes/hydrazones with [O, N, O] and dithiocarbamates with [S, S] donor ligands. The methodologies described herein includes; the synthesis of five versatile Schiff bases/hydrazones ligands; N'', N''-4-bis(2-hydroxybenzylidene)oxalohydrazide(H4L1), N'', N''-4-bis(2-hydroxylbenzylidene)malonohydrazide (H4L2), N′, N′-4-bis(2- hydroxybenzylidene)succinohydrazide (H4L3), N′, N′-4-bis(2-hydroxybenzylidene)glutarohydrazide (H4L4) and N′, N′-4-bis(2-hydroxybenzylidene)adipohydrazide (H4L5). Herein the thesis also embodied another series of five dithiocarbamates ligands of the types; dipotassium-2, 2-oxalylbis(hydrazine-1-carbodithioat) (K2L1), dipotassium-2, 2-malonylbis(hydrazine-1-carbodithioate) (K2L2), dipotassium2, 2''-succinylbis(hydrazine-1-carbodithioate) (K2L3), dipotassium-2, 2''-glutaroylbis(hydrazine-1-carbodithioate) (K2L4) and dipotassium-2, 2''-adipoylbis(hydrazine-1carbodithioate) (K2L5). For the synthesis of organotin(IV) complexes the reaction between Schiff bases/ hydrazone ligands with [O, N,O] donor sites, mono- and diorganotin(IV)chlorides/oxides were carried out at various reaction conditions and obtained fifty new organotin Schiff bases/hydrazone complexes. The reaction between dithiocarbamae ligands with [S, S] binding sites, mono- and diorganotin(IV)chlorides were unsuccessful and end up with desulfurized isothiocynates. The structural and coordination chemistry of ligands with O, N, O and S, S binding mode/sites and thier organotin(IV) complexes were investigated by using FT-IR and single crystallographic studies in the solid sate. The solution chemistry of these complexes was investigated through mass spectrometry and some multinuclear (1H, 13C and 119Sn) spectal studies. The results revealed that Schiff bases/hydrazones coordinate to tin through a tridentate mode using [O, N, O] binding mode. The structural analysi of single crystal by X-ray technique showed that organotincomplexes procured from hydrazone with tridentate lignads (O, N, O), mono- and diorganotin(IV) chlorides exhibited distorted octahedral (oh) and distorted trigonal bipyramidal (tbp) geometry respectively.Based on the computational studies; the trigonal bipyramidal complexes showed a Sn···O tetrel bonding/interaction in the solid state. A computational study, in combination with the quantum theory of atoms in molecules (QTAIM) shows that the Sn···O interactions involved here are purely electrostatic in nature with little covalent character and leads to a shorter Sn···O [3.480(2 Å)] inter-atomic bond distance as compare to the reported “sum of van der Waals radii (3.92 Å)”. However, these types of interaction cannot be seen in the compounds when the phenyl /butyl groups or when the methylene spacer (-CH2-) between the two-hydrazone fragments is increased replaces the methyl groups. Finally, all the complexes were screened for anticancer activities using carbopaltin as a standard drug. The diorgantotin hydrazone complexes;wheremethyl and phenyl groups are attached to tin(IV)showed reasonable activities due tosolubility problems but the dibutyltin(IV) complexes of the hydrazone [O, N, O] ligands showed excellent activities and have been used as representative sample (compounds) against various cancer cell lines (HL-60, MCF-7 and HeLa ) obtained from human being. It is assumed that the high cytotoxic activities of the dibutyl tin(IV) complexes are due to its lipophilic character and can be compared with the activity of the standard drug (carboplatin). These results might be helpful in the rational drug designing of those complexes containing the dibutyl moiety.