مولانا عبدالحفیظ بلیاوی
افسوس ہے کہ دارالعلوم ندوۃ العلماء کے استاذ مولانا عبدالحفیظ صاحب بلیاوی نے وفات پائی وہ ادب کے استاد تھے، عربی زبان و لغت پر ان کی نظر بڑی گہری و وسیع تھی، انہوں نے لغت کی کئی کتابیں لکھیں، ان میں مصباح اللغات اور اردو عربی ڈکشنری چھپ گئی ہیں بعض مسودے کی شکل میں ہیں، دینی علوم میں بھی پوری دستگاہ رکھتے تھے، ان کی پوری زندگی عربی زبان کی تلاش و تحقیق میں گذر ی، ان کی وفات سے عربی زبان کا ایک بڑا ماہر اٹھ گیا، اﷲ تعالیٰ اس شیدائے علم کی مغفرت فرمائے۔
(شاہ معین الدین ندوی، ستمبر ۱۹۷۱ء)
The individual’s personality, character, thinking, skills and habits depends upon education. Education helps in the growth and boost the qualities of an individual such as physical, mental and emotional make-up as well as temperament and character. This paper enlightens the significant role of education in developing and mounting the personality of ‘Omar Ibn alKhattāb (R.A). He was one of the most powerful and influential Muslim caliphs. His vibrant ideology of superiority of principles and laws made him eminent among his acquaintances. He was a man of determination and a mission, therefore, he thought, evaluated and acted according to it. He established a system of justice, morality, education and training. He was born as an ordinary‘Omar but education and guidance of Islam made him “‘Omar The Great”. This paper ends with the note that a balanced, successful and well-adjusted personality can be designed only by educating the individuals. Educational institutions, religious organizations and enrich culture play an important role in shaping the sturdy personality as is evident in case of ‘Omar(R.A).
The main focus of this PhD research project is the isolation, structure elucidation and bioassay of steroidal alkaloids of medicinally important plant Sarcococca saligna, belongs to Buxaceae family. Five compounds were isolated from the chloroform fraction of S.saligna through phytochemical investigation i.e. Alkaloid-C (1), Dictyophlebine (2), Sarcovagine-D (3), Saracodine (4) and Holaphylline (5). The structure of compounds was determined through modern spectroscopic techniuqes. These steroidal alkaloids were then screened for various In-vivo biological assays such as hepatoprotective and antidiabetic, while also tested In-vitro biological activities such as immunosuppresent, antibacterial, antifungal, phtotoxicity, insecticidal, cytotoxicity and leshmanicidal activity. The compounds were also investigated as steroidal aromatase inhibitors through molecular docking studies against breast cancer. The selected steroidal alkaloids were screened for In-vivo hepatoprotective and antidiabetic activities. The compounds 1, 3 and 5 markedly decreased hepatic injury by CCl4-injury inducer and mixed inflammatory penetration. Therefore, we explored and suggest that steroidal alkaloids from S.saligna could be excellent hepatoprotective agents. The isolated steroidal alkaloids were also tested for the antidiabetic potential and the result showed that compounds 3 and 5 reduced the glucose level significantly in blood and also make better others diabetes associated complications. The isolated steroidal alkaloids were screened for In-vitro biological assays. Compound 1, 3 and 5 were screened for immunosuppressant activity. Compounds showed inhibitory activities of T-cell proliferation in the range of 78 to 95% and also inhibit IL-2 production which means the tested compounds were excellent immunosuppressive agents. The compounds 2, 3 and 5 were screened for antibacterial activity. The compound 2 showed significant antibacterial activity against S.aureus (79%). The compound 3 showed significant antibacterial activity against P.aeruginosa (79%), while compound 5 showed good antibacterial activity against B.subtilus (72%) and P.aeruginosa (69%) respectively. The isolated steroidal alkaloids were screened for antifungal activity against various pathogenic fungi and showed low to moderate antifungal actions. Compounds 1 and 3 showed low antifungal activity while compound 5 showed moderate antifungal activity against selected pathogenic fungi. The selected steroidal alkaloids were also screened for antileshmanial activity. Compounds 4 showed moderate antileshmainal activity while compound 5 showed significant inhibition against the promastigotes of L. tropica. The phytotoxic effect of compound 5 was observed maximum 66%, while 1 and 2 showed low activity at different concentration level. The isolated steroidal alkaloids were tested for insecticidal activity and among them compound 5 showed maximum activity 65% against T.castaneum, while showed low activity against R.dominica and C.analis (20% and 10%) respectively. The selected steroidal alkaloids were screened for antioxidant actions in which compounds 3 and 5 showed significant antioxidant actions and radical scavenging activity increased up to 78% and 80%. The isolated compounds were also screened for anticancer activity in which compound 2 found to be more active with IC50 value 6.13±0.345, while compound 1 showed moderate anticancer activity with IC50 values 12.98±0.235 against HeLa cells lines. The compounds were to explore as a new steroidal aromatase inhibitors through molecular docking studies in which compound 5 and 1 were active against aromatase enzyme in breast cancer could provide new lead compounds.