83. Al-Mutaffifin/The Defrauders
I/We begin by the Blessed Name of Allah
The Immensely Merciful to all, The Infinitely Compassionate to everyone.
83:01
a. Woe to the defrauders,
83:02
a. those who take full measure when they measure against the people,
83:03
a. yet whenever it would be giving the right of others, they reduce the measure for themselves or weigh for themselves.
83:04
a. Do they not realize that they will be resurrected from their graves and held accountable for their cheating -
83:05
a. - during an Awful Time,
83:06
a. - the Time when everyone – all humankind - will stand accountable before Rabb - The Lord of all existence?
83:07
a. They think all will be equal at the Time of Final Judgment.
b. Not at all!
c. The book/record of deeds of the sinful will be preserved in Sijjeen.
83:08
a. And what may enable you to perceive Sijjeen?
83:09
a. It will be repository of a written book.
83:10
a. Woe, that Time, to those who belie -
83:11
a. those who belie persistently the truth of the Time of Final Judgment.
Surah 83 * Al-Mutaffifin 721
83:12
a. And no one can deny it, except every transgressor and sinful.
83:13
a. Whenever OUR Messages from The Qur’an are read out to him, he would rebuke:
b. ‘Fictional tales of an ancient people!’
83:14
a. Of course not!
b. Rather what they have earned has covered their hearts like rust.
Youth play an important and key role in the development of a nation. They bring change and progress in society. Youth are not only the leaders of tomorrow but also the partners of today. Revolutionary thoughts only come in youth. Youth of any nation play a pivotal role in all the activities in all the fields of life. All the progress in the field of economics, engineering, medical, arts, politics are the fruits of the passions, dreams and hope of youth. So keeping in view the importance of youth in this article, definition and true meaning of youth have be explained. What period is called a youth period? It is also been discussed in the light of the opinion of different thinkers and scholars. What should be the targets to train the youth. How can a young person be molded and trained into a pious, noble and honest person. This article answers all the questions. It is also suggested that Prophetic method to train the youth in order to fully utilize their capabilities, potentialities and abilities should be adopted. To give them respect, to educate and train them, to make them involve in constructive activities, to engage them in Halal earning and to develop confidence in them are the major action that should be taken to meet the challenges of the future and live a successful life in present. Today’s youth should dedicate their lives for Islam by contributing their time, energies and money, youth as the phase of life when an individual can grasp knowledge of Islam and follow it by utilizing his time and talent in the service of humanity by following prophet Muhammad as a role model. All these points are discussed in detail in this article
The work embodied in the present thesis consists of two parts. Part A deals with the phytochemical studies on Lantana camara Linn., while part B describes the structure-activity relationship studies on some β-carboline alkaloids. A brief review of the biosynthesis of terpenoids with particular reference to the pentacyclic triterpenoids is also provided. PART A The introduction of Part A affords a review of the earlier contributions made in the chemistry and pharmacology of the genus Lantana and a brief account of the present work. Studies undertaken on the methanolic extract of the air dried aerial parts and roots of Lantana camara Linn. led to the isolation and structure elucidation of twenty four compounds including four new (17, 18, 21 and 23) and twenty known (1-16, 19, 20, 22 and 24) natural products. Compound 11 is hitherto unreported from aerial parts of the plant whereas compounds (4, 9 and 19) are reported for the first time from the genus Lantana. The constituents obtained in the present studies are listed below: Compounds obtained from aerial parts New Compounds 1. Lantanolide (17) 2. Lancamarolide (18) 3. Lancamarinic acid (21) 4. Lancamarinin (23) Known Compounds 5. Oleanonic acid (1) 6. b-Sitosterol (2) 7. Lantadene A (3) 8. 3-Oxo-11α-hydroxy-urs-12-ene-28-oic acid (4) 9. Oleanolic acid (5) 10. Ursolic acid (6) 11. Ursonic acid (7) 12. Betulinic acid (8) 13. 3β-Acetoxy Betulinic acid (9) 14. Lantadene B (10) 15. Pomonic acid (11) 16. Lantanilic acid (12) 17. Camaric acid (13) 18. Camarinic acid (14) 19. Lantaninilic acid (15) 20. Lantoic acid (16) 21. Stigmasterol (19) 22. Lantanolic acid (20) 23. Lantic acid (22) 24. β-Sitosterol-3-O-β-D-glucopyranoside (24) Compounds obtained from roots 1. Oleanonic acid (1) 2. Oleanolic acid (5) 3. Lantanilic acid (12) 4. β-Sitosterol-3-O-β-D-glucopyranoside (24) In the present investigation, the crude methanolic extract of the aerial parts of Lantana camara, its fractions and some pure compounds were evaluated for antileishmanial, nematicidal, mosquito larvicidal, anticancer and antioxidant activities. In addition, the extract and fractions were also evaluated for mosquito repellent, antibacterial, antifungal and insecticidal activities. Some pure compounds were also tested for immunomodulatory and enzyme inhibition activities. PART B The introduction of part B provides a review of the earlier contributions made in the chemistry and pharmacology of the β-carboline alkaloids – the harmine series of alkaloids. This part of the dissertation deals with the structure - activity relationship studies in the β-carboline alkaloids harmine (1), harmol (2) and harmalol (3) leading to the synthesis of thirty six derivatives (4-39) including eight new β-carbolines (20-25, 33 and 34) and five new tryptamine (35-39) derivatives along with several known compounds. Compounds 1 and 4-6 were tested for their leishmanicidal activity. Nematicidal activity of 2, 7, 8, 14-17 and 20-25 have also been determined. In addition compounds 2, 3 and 26-39 were tested for their antibacterial and antifungal activities. Some compounds were also investigated for their anticancer, chymotrypsin and urease inhibitory activities. The compounds synthesized in the present study are listed below: 1. 10-Bromo-11-methoxy-3-methyl-b-carboline (4) 2. 12-Bromo-11-methoxy-3-methyl-b-carboline (5) 3. 10,12-Dibromo-11-methoxy-3-methyl-b-carboline (6) 4. 10-Bromo-11-hydroxy-3-methyl-b-carboline (7) 5. 12-Bromo-11-hydroxy-3-methyl-b-carboline (8) 4 6. 11-Ethoxy-3-methyl-b-carboline (9) 7. 11-Butoxy-3-methyl-b-carboline (10) 8. 11-Isobutoxy-3-methyl-b-carboline (11) 9. 11-Pentoxy-3-methyl-b-carboline (12) 10. 11-Hexoxy-3-methyl-b-carboline (13) 11. 11-Heptoxy-3-methyl-b-carboline (14) 12. 11-Octoxy-3-methyl-b-carboline (15) 13. 11-Nonoxy-3-methyl-b-carboline (16) 14. 11-Decoxy-3-methyl-b-carboline (17) 15. 11-Allyloxy-3-methyl-b-carboline (18) 16. 11-Benzyloxy-3-methyl-b-carboline (19) 17. 11-2-Iodobenzyloxy-3-methyl-b-carboline (20) 18. 11-3-Iodobenzyloxy-3-methyl-b-carboline (21) 19. 11-4-Iodobenzyloxy-3-methyl-b-carboline (22) 20. 11-2-Nitrobenzyloxy-3-methyl-b-carboline (23) 21. 11-3-Nitrobenzyloxy-3-methyl-b-carboline (24) 22. 11-4-Nitrobenzyloxy-3-methyl-b-carboline (25) 23. 11-Acetoxy-3-methyl-b-carboline (26) 24. 11-Propionyloxy-3-methyl-b-carboline (27) 25. 11-Butyryloxy-3-methyl-b-carboline (28) 26. 11-Valeryloxy-3-methyl-b-carboline (29) 27. 11-Hexanoyloxy-3-methyl-b-carboline (30) 28. 11-Heptanoyloxy-3-methyl-b-carboline (31) 29. 11-Octanoyloxy-3-methyl-b-carboline (32) 5 30. 11-Nanoyloxy-3-methyl-b-carboline (33) 31. 11-Decanoyloxy-3-methyl-b-carboline (34) 32. 2-Acetyl-3-(2-nonanoylamidoethyl)-7-nonanoyloxyindole (35) 33. 2-Acetyl-3-(2-decanoylamidoethyl)-7-decanoyloxyindole (36) 34. 2-Acetyl-3-(2-trichloroacetamidoethyl)-7-trichloroacetoxyindole (37) 35. 2-Acetyl-3-[2-(2-trifloromethylbenzoyl)-amidoethyl]-7-(2- trifloromethyl benzoyloxy)-indole (38) 36. 2-Acetyl-3-[2-(3-trifloromethylbenzoyl)-amidoethyl)-7-(3- trifloromethyl benzoyloxy)-indole (39) Nematicidal activity was determined by Prof. Dr. Shaheena Fayyaz (Director) of the Institute of Nematological Research Center and Prof. Dr. Aly Khan (Director) of the Crop Disease Research Institute, Pakistan Agricultural Research Council, University of Karachi. Antimicrobial, antioxidant and immunomodulatory activities were tested by Prof. Dr. Aqeel Ahmed, Department of Microbiology, University of Karachi. Mosquito larvicidal and repellent activities were evaluated by Dr. M. Tariq Rajput, MAHQ Biological Research Centre, University of Karachi. Antileishmanial, anticancer, insecticidal and enzyme inhibition activities were determined by the bioassay screening section staff of this institute under the guidance of Prof. Dr. Muhammad Iqbal Choudhary. Extensive spectroscopic techniques such as UV, IR, EI-MS, HREI-MS, 1H- and 13C- NMR (Broad Band decoupled and DEPT), 2D NMR (1H-, 1H- COSY, NOESY, TOCSY, J-resolved, HMQC and HMBC) and chemical reactions were employed to elucidate the structures of the new compounds. The work embodied in the present dissertation has resulted in five research publications as listed in the list of publications.