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Development of Electrochemical Sensors for the Analysis of Drugs and Detection of Water Toxins

Thesis Info

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Author

Munir, Azeema

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Physical Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10735/1/azeema%20munir_QAU_2019_chemistry.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676724618979

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The current research work is intended at the designing of a various electrochemical sensors for the analysis of pharmaceutical drugs and detection of toxic heavy metal ions. Three types of electrochemical sensors were prepared and characterized. These include nanosensors, DNA biosensors and surfactant based electrochemical sensors. In the electrochemical nanosensors, TiO2 nanoparticles and COOH functionalized MWCNTs were used as receptors for the sensing of oxymetazoline drug (OMZ). The designed nanosensor helped in the sensing of OMZ with a 4.4 nM detection limit. In the second type of electrochemical sensor, DNA was used a receptor over the surface of transducer. The designed DNA biosensors were employed for the detection of a number of Schiff bases, i.e., 2-((3-chlorophenylimino)methyl)-5-(diethylamino)phenol (2-CPMP), 2-((2,4dichlorophenylimino)methyl)-5-(diethylamino)phenol (2-DPMP), 5-(diethylamino)-2((3,5-dimethylphenylimino)methyl)phenol (5-DDPMP) and 5-(diethylamino)-2-((2,6diethylphenylimino)methyl)phenol (5-DDMP). All the Schiff bases were found to interact with DNA and interestingly the oxidation signal of 5-DDMP registered 30 times increase at the fMWCNTs fabricated DNA biosensor compared to DNA biosensor alone. Moreover, surfactant based electrochemical sensors were also designed and applied for the simultaneous detection of several toxic heavy metal ions. For this purpose, 1-dodecanoyl3-(4-methoxyphenyl)-2-thiourea and 1-(3-chlorophenyl)-3-dodecanoylthiourea were used as recognition layers for the simultaneous and sensitive sensing of four and six metal ions, respectively. The electrochemical behavior of the targeted analytes at the developed sensors was probed by adsorptive stripping differential pulse voltammetry (ASDPV) and cyclic voltammetry (CV). The performance parameters of the developed sensors were evaluated from EIS, CV and ASDPV. The conditions i.e. concentration of modifiers, type of electrolyte, pH of medium deposition potential and deposition time were optimized for getting the highest current response to achieve the lowest detection limits of the targeted analytes. The modified electrodes were tested for real samples to check their validity for practical applications. The results revealed all the designed sensors to demonstrate the qualities of excellent sensitivity, selectivity and reproducibility
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مولانا محمد شمیم کیرانوی

مولانا محمد شمیم کیرانوی
افسوس ہے کہ شعبان المعظم کے آخری ہفتہ میں مدرسہ صولتیہ مکہ معظمہ کے ناظم مولانا محمد شمیم کیرانوی وفات پاگئے۔ اس مدرسہ کی داغ بیل ترکوں کے دور میں اس وقت پڑی تھی، جب حجاز میں مدرسوں کی تعداد بہت کم تھی، پہلے اس کی زمام کار مولانا رحمت اﷲ کیرانوی نے سنبھالی جن کا خاص مشن ردمسیحیت تھا۔ اظہارالحق کی تصنیف اور مشہور پادری فنڈر کو عبرتناک شکست دینا ان کا بڑا کارنامہ تھا۔
مولانا محمد شمیم کے والد بزرگوار مولانا محمد سلیم کیرانوی کی نظامت کے زمانہ میں مدرسہ صولتیہ نے بڑی ترقی کی۔ ان کی وفات کے بعد مولانا محمد شمیم صاحب نے مدرسہ کے لیے اپنی خدمات وقف کردی تھیں، انھوں نے اپنے والد ماجد کی روایات کو باقی رکھا۔ ہندوستان سے حج و زیارت کے لیے تشریف لے جانے والے علماء مشائخ کے آرام و آسائش کا وہ بڑا خیال رکھتے اور ان کو ہر قسم کی مدد اور سہولت بہم پہنچاتے۔ معارف اور دارالمصنفین کے بھی قدردان تھے اور کبھی کبھی خطوط لکھ کر ان سے اپنے تعلق کا ثبوت دیتے۔ مولانا کی عمر ابھی کچھ زیادہ نہیں تھی لیکن ان کی حیات مستعار کے دن پورے ہوچکے تھے۔ اﷲ تعالیٰ ان کو اپنے جوار رحمت میں جگہ دے اور مدرسہ کو ان کا نعم البدل عطا فرمائے، آمین۔
(ضیاء الدین اصلاحی، اپریل ۱۹۹۲ء)

 

Modernism and Postmodernism

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Molecular Identification and Characterization of Some Novel Halotolerant Rhizobacteria Containing Acc-Deaminase, for Growth Promotion of Phaseolus Vulgaris L. under Salt Stress

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