مولانا حکیم سید محفوظ علی
افسوس ہے نومبر کی ۲؍ تاریخ کوہماری جماعت دیوبند کے ایک نامور رکن مولانا حکیم سیدمحفوظ علی صاحب نے کم وبیش ستر برس کی عمر میں دیوبند میں داعی اجل کولبیک کہااور رہ گزائے عالم آخرت ہوگئے۔ موصوف دارالعلوم دیوبند کے فارغ التحصیل تھے اور علوم عقلیہ ونقلیہ دونوں میں کسی میں کم اور کسی میں زیادہ پختہ استعداد رکھتے تھے۔ فراغت کے بعد کچھ دِنوں مدرسہ میں بحیثیت معین المدرسین چند ابتدائی کتابوں کادرس بھی دیا ۔مگر طبیعت میں فنِ طب کی طرف شدید میلان پیدا ہوا تو دلّی کے نامورطبیب حکیم عبدالوہاب عرف نابینا مرحوم کی خدمت میں چندسال رہ کر اس شوق کی تکمیل اس خلوص، محنت اورانہماک سے کی کہ علماً وعملاً ایک ممتاز صاحبِ فن اوراُستاد کے لائقِ فخر ومعتمد علیہ تلمیذ رشید بن گئے۔ اب دِلّی سے رُخصت ہوکر دیوبند میں ہی انہوں نے مطب جمایاتو چندہی مہینوں میں اُن کے حذاقتِ فن اوردستِ شفاء کی شہرت دُور دورتک پہنچ گئی۔ اور اُن کامطب مرجع خواص و عوام ہوگیا ۔فنّی کمال ومہارت کے علاوہ اخلاقی اعتبارسے بھی بڑے خلیق ومتواضع، خوش طبع وخندہ رو اور غیرت وخودداری کے ساتھ حد درجہ مخلص وبے لوث انسان تھے یہی وجہ ہے کہ جس توّجہ سے وہ مریضوں کا علاج کرتے تھے اُسی توّجہ اور خلوص سے طلباء کوطِب کادرس خالصۃً لوجہ اﷲ دیتے تھے۔
حضرت شاہ صاحب ؒ کے قریبی عزیز تھے۔اِس تعلق سے ہم خدام بارگاہ کے ساتھ غیر معمولی شفقت ومحبت اور التفات وتوجّہ کامعاملہ کرتے تھے۔ ان خدام میں میں سب سے کم عمربھی تھااور کم مایہ بھی،مگر اُن کاجوشِ التفات وکرم ان حدود کی پروا نہیں کرتا تھا۔ ہم اُن کواپنا مخدوم ومحترم مانتے تھے اور وہ ہمارے ساتھ بالکل عزیزوں کاسا برتاؤ کرتے تھے۔ گذشتہ اکتوبر کی ۲۸؍ تاریخ کوایک کمیٹی کی میٹنگ...
Dealings of the Holy Prophet (S.A.W) with non-Muslim show that Islam is the religion of peace, brotherhood, religious tolerance, independence and humanity. Before the spread of Islam the conversations and dealings of the Holy Prophet with non-Muslims forced them to call him Al-Sadiq and Al-Ameen. Sympathy and tolerance in clandestine and public preaching, the style of letters to non-Muslim empires, the dialogues with non-Muslim delegations in Madani era, the orders given for the safety of their wealth, belongings and their life, the tolerance, forgiveness and prayers for the enemies, the good behavior with the non-Muslim prisoners, even when Muslims got dominance over non-Muslims at the time of the conquest of Makkah, the common pardon given by Holy Prophet (S.A.W) are the true example that Islam preaches peace. The attitude of Sahaba-e-Karam (R.A) and the liberty of rights given to Non-Muslims by them- no religion and no community of the World can give this example. The people responsible for maintaining the peace of the world and brotherhood should see how Muslims are treated all over the world? Muslims had given to non-Muslim permission to practice their religious festivities freely and even to wear any type of clothes. The ban of Hijab in France, the punishment of innocent Dr. Afia Siddiqui, the Egyptian pregnant woman (Marwa Sharbeney) had been mercilessly assassinated and her husband injured by knives in the court of Germany because of Hijab, the discussions going on to restrict the domes of Mosques and Adhan (Call to prayer) in Switzerland, the insult of the Holy Quran by Pope Terry John, of Florida, the disrespect of Holy Prophet (S.A.W) etc are the questions awaiting answers from West and United Nation. Islam promotes of peace, equality and religious freedom. It also invites non-Muslims to come and sit on a platform and discuss these problems for the sake of worldly peace to end the religious hatred and to form true peace in the world.
This research work comprises of the synthesis of quinazoline derivatives and evaluation of their in vitro biological activities. The chemical structures of synthetic compounds were characterized by several spectroscopic techniques such as 1H-NMR, 13C-NMR, IR, EI-MS, and HREI-MS. Melting points and Rf values were also taken. This dissertation is divided into two chapters based on literature survey and research findings. Each chapter has its own compound numberings and references. Chapter 1 This chapter deals with the extensive literature survey on the heterocyclic compounds; especially quinazolines, their biological importance and synthetic protocols; several biological activities which were carried out on synthetic compounds; and research plan. Chapter 2 This chapter deals with the syntheses of compounds 3-27, 32-55, 59-82, 86-125, 129-155, 158, 161-184, 187-210, and 213-236 and evaluation of their various in vitro bioactivities. Compounds 4-7 and 9-27 were found to have several hundred folds better inhibitory potential against α-glucosidase, when compared to the standard drug, acarbose. For the β-glucuronidase inhibition, compounds 3-6, 10, 11, 13-17, 19-21, 23-27 showed better activity than the standard, D-saccharic acid 1,4-lactone. Compounds 5, 8, 10, 14, 17, and 19 selectively displayed thymidine phosphorylase inhibition. For xanthine oxidase inhibition, compound 13 showed the activity similar to the standard, allopurinol. Compound 19 showed better activity than the standard, EDTA against phosphodiesterase inhibition. Compounds 3, 17, 23, and 24 demonstrated weak inhibitory potential against carbonic anhydrase inhibition. Compounds 38 and 51 exhibited the best activity against leishmaniasis when compared to standard, pentamidine. Compounds 4, 6, 7, 12, 16, 17, 19, 59, 66, 74, 76, 78, and 80 showed weak activity for the pancreatic β-cell viability studies. Compounds 6, 13, and 25 showed excellent superoxide anion radical scavenging activity. Compounds 88, 91, 102, 103, 119, 133, 137, 144, and 153 were found to have better anti-inflammatory potential than the standard drug, ibuprofen. All synthetic compounds were found to be inactive for α-chymotrypsin, dipeptidyl peptidase, and urease inhibitions, and antiglycation studies.