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Effects of Dibutyl Phthalate As an Endocrine Disruptor on Growth, Glucose Homeostasis, Lipid Metabolism and Redox Status in Laboratory Animals

Thesis Info

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Author

Majeed, Khalid Abdul

Program

PhD

Institute

University of Veterinary and Animal Sciences

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Physiology

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/11134/1/Khalid%20Abdul%20Majeed_Physiology_2018_UVAS_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676724671372

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Dibutyl phthalate, a known endocrine disruptor, is a commonly used plasticizer that influences the glucose homeostasis. The present study elucidates the effects of dibutyl phthalate (1 and 5 mmol/L) on electrogenic sodium-linked glucose transport in the isolated rabbit ileum with ‘Ussing chamber.’ Serosal addition of dibutyl phthalate has no effect on glucose-based electrogenic changes in short circuit current, and no effect of dibutyl phthalate is observed on ileal tissue conductance and catalase activity. However, mucosal addition of dibutyl phthalate in the presence of glucose shows a trend of decrease in short circuit current compared with the control. This indicates that dibutyl phthalate may have a deleterious effect on the electrogenic intestinal glucose transport.
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