The present research explored impact of perceived social support, social skills and coping strategies on general health of Pakistani women college and university teachers. Non-probability purposive sampling strategy was used. The sample comprised of 212 women college and university teachers drawn from different public and private colleges and women university of Lahore. Perceived Social Support from Friend and from Family Scales (Procidano & Heller, 1983); Social Skills Inventory (Riggio, 1989); Coping Orientation to Problem Experienced (Carver, Scheier, & Weintraub, 1989) and General Health Questionnaire 30 (Goldberg, 1978) were individually administered to all the research participants. Formal permission was granted by the authors of these scales for use in the current research project. Pearson Product Moment Correlation coefficient, Hierarchical Multiple Regression Analysis and Structural Equation Modeling were performed to determine the impact of perceived social support, social skills and coping strategies on general health of the research participants. Independent sample t-test was also applied to analyze the differences between single and married women college and university teachers in all variables. The Results suggest that perceived family support, social skills, emotion-focused coping strategies and problem-focused coping strategies are significant positive predictors for general health of women college and university teachers in Pakistani society. The findings of this research have implications for promoting our understanding of the impact of perceived social support, social skills and coping strategies on general health of the women college and university teachers so that faculty development programs could be introduced in Pakistani educational institutions to promote their general health.