A lot is written about third party logistics, its evolution and rapid growth especially in western world and few of the Asian countries. Most of the research done on third party logistics is from customers’ perspective regarding their needs, reasons and motives to outsource logistics services and the standard of service what customers are looking for or what they are getting. The flip side of it, is the perspective of logistics service providers which is, mostly confined to national and international surveys and demographic statistics. About a decade back, World Bank started calculating Logistics Performance Index and ranking all internationally trading countries on the basis of their logistics infrastructure and performance. In Pakistan this industry was completely ignored and was rather unknown to academic researchers until the China Pakistan Economic Corridor came into lime light. Even then, it cannot be said that this industry got due attention from academic researchers or even from government regulatory authorities to properly regulate this industry. It is only in the last decade that researchers in Pakistan turned their attention towards this industry to evaluate its capacity, span of services provided, quality of service and the performance of third party logistics service providers. This research is unique in nature, as never before the service competencies of logistics industry in Pakistan were evaluated using internationally recognized quality standards and competency measures. To study the impact of quality management practices on service competencies of third party logistics service providers in Pakistan, this research picked the two most renowned and internationally recognized models: The Malcolm Baldrige National Quality (MBNQ) model for assessing quality management practices and Michigan State University Global Logistics Research Team (MSUGLRT) model for service competencies. The impact of six quality management factors of MBNQA named 1- Leadership, 2- Strategic Planning, 3- Customer Focus, 4- Measurement, Analysis and Knowledge Management, 5- Human Resource Focus and 6- Process Management was studied on the four service competency identified by MSUGLRT named 1- Positioning, 2- Integration, 3- Agility and 4-Measurement. The data on various items for these latent constructs was collected from more than 200 firms and all necessary analyses using AMOS and SPSS packages were done to find out the direction and extent of the impact of quality factors on service competency. Also the effect of Social Capital and Company Strength as moderating variable was observed. The results clearly identified the Strategic Planning and HR Management Focus as the factors highly impacting service competencies of third party logistics service providers in Pakistan. Interestingly, but surprisingly, the role of Leadership and Knowledge Management was minimal. Especially the negative impact of Leadership indicates the area of immediate further attention. The moderating variable also had very significant relation with service competencies but they were unable to significantly affect the individual impact of other quality factors. This study highlights the areas where logistics firms in their individual capacity, the logistics industry as a whole and concerned government bodies must immediately concentrate to be able to extract expected benefits from the China Pakistan Economic Corridor.
اسلام ایک مکمل دستور زندگی اور ضابطہ حیات ہے۔ اس کے قوانین جہاں ناقابل ترمیم ہیں، وہاں ان میں حالات کی تبدیلی کے ساتھ لچک بھی پائی جاتی ہے۔ زندگی کے نئے پیش آمدہ مسائل و پیچیدگیوں کے حل کی کنجی اسلام کے پاس ہے، کیونکہ اس کے اصول ابد ی و آفاقی ہیں۔ اسلام نے معاشرے کی اخلاقی اقدار کے تحفظ کے اصول و ضوابط بیان کیے ہیں اور یہ بتلایا ہے کہ معاشرہ کی اخلاقی اقدار کاتحفظ لازم ہے۔ اگر کوئی اس کا خیال نہیں کرے گا تو معاشرہ اس کے حقوق کو تحفظ بھی فراہم نہیں کرے گا اور اس پر حد(سزا) بھی جاری کرے گا۔ دوسرا اسلام نے لوگوں کو فرائض کی ادائیگی کا حکم دیا ہے اور ان کے حقوق کی گفتگو انہی فرائض کے ضمن میں آ گئی ہے ۔ جب لوگ فرائض کی ادائیگی میں دلچسپی لیں گے تو خود بخود ان کے حقوق کا تحفظ ہوتا رہے گا۔ یہی وہ بنیادی فرق ہے جو اسلامی اور وضعی قوانین میں واضح طور پر نظر آتا ہے۔ اسی کی بنیاد پر جرم و سزا کے قوانین سامنے آتے ہیں ۔ انہی قوانین کی بنیاد پر ہی معاشرے کی اخلاقی اقدار کو محفوظ بنایا جاتا ہے۔ دنیا میں امن وسکون اسی اسلامی فلسفہ کا ہی مرہون منت ہے۔
دین اسلام میں گناہوں سے دور رہنے اور ان سے بچنے کے ضابطے درجہ بدرجہ تفصیلاً بیان ہوئے ہیں ،لیکن پہلے تربیت کے مواقع فراہم کیے گئے ہیں ، پھر آخری درجے پر سزا کا حکم دیا گیا ہے۔ اس عملی کام کے علاوہ نظری طور پر اسلام کے بنیادی عقائد بھی انسان کی بھر پور تربیت کرتے ہیں...
Growth factors are the potential operational members which control different phases of liver regeneration. Different growth factors have expression regulation in the whole process relating to different phases of liver regeneration. Objective: To assess the expression regulation of different growth factors and cytokines involved in liver regeneration in a phase-dependent manner. Methods: Blood and liver samples were collected and analyzed on 1st, 3rd, 5th, 7th and 14th postoperative days after 50% Partia hepatectomy (PHx). Results: Steady increase of liver regeneration rate was recorded from 90.8% (1st day) to 97.9% (7th day). Liver function tests further confirmed the steady liver recovery in PHx mice. Several growth factors such as HGF and VEGF exhibited an up-regulation till 5th day and later gradual decrease till 14th day compared to control mice. Albumin, CK18 and CK19 showed sequential expression increase from 1st to 14th day compared to AFP and HNF-4α upregulated until 5th and 1st day, respectively. Quantification of these growth factors further confirm our results. Conclusions: Conclusively, these results highlight a phase-dependent regulation and role of growth factors in liver regeneration and recovery
Osteoarthritis (OA) is one of the most common musculoskeletal disorders and a significant health concern worldwide. It may affect any hyaline cartilage containing joint. Knee is most commonly affected joint with OA and it is one of the leading causes of disability in elders. Degradation of cartilage tissue, joint space narrowing and synovitis are major signs of OA. OA is usually diagnosed by clinical symptoms like pain and lack of mobility and confirmed by radiographs. The Kellgren and Lawrence (KL) grading index is used to classify the severity of OA based on structural changes. It is considered that there is a correlation between X-ray findings and clinical symptoms of OA but in literature diverse opinions are present about the discordance between clinical and radiographic advances of disease in different ethnic groups. In the current study, the association between knee OA (KOA) radiographic evidence and its clinical outcomes were investigated in Pakistani population. One hundred and seventy subjects with diagnosed KOA were enrolled in this study. Patients were categorized into four different groups based on their radiographic disease severity determined by KL grading index. Clinical symptoms of OA were assessed using Knee injury and Osteoarthritis Outcome Score (KOOS) instrument. We have found a positive association between KOA X-rays severity and clinical symptoms like pain, symptoms and activities of daily life (ADL) (P <0.05). We have also observed an inverse relationship between health related quality of life (HR-QOL) and radiographic structural changes in KOA patients (P value <0.0001). Initially, OA was considered as a non inflammatory disease but recent evidences have suggested the involvement of certain inflammatory molecules including cytokines in OA disease progression and development. Single nucleotide polymorphisms (SNPs) in proinflammatory cytokines are also thought to play some vital role in pathology of OA. In present study, tumor necrosis factor alpha (TNF-alpha, -309 G>A, -238 G>A), Interleukin 6 (IL6, -572 G>C) and resistin (RETN, -420 C>G, +299 G>A) genetic variants were analyzed in knee OA patients (n=280) and healthy control group (n=308) to find out the involvement of these mutant genotypes in OA disease pathology in a Pakistani population. PCR coupled with restriction fragment length polymorphism (RFLP) technique was performed for genotyping investigation. Resistin is comparatively a new candidate gene in inflammatory pathologies whereas SNPs in TNF-alpha and IL6 have been explored in OA patients among different population with contradictory results. Serum resistin level was also determined by enzyme linked immunosorbent assay (ELISA) technique. A significantly positive association was found between knee OA disease and TNF-alpha (-309 G>A, -238 G>A) and IL6 (-572 G>C) polymorphisms (p<0.05). Our findings also demonstrated a considerable connection between RETN -420G variant allele (P=0.001) and KOA. RETN polymorphism at +299 G>A site also showed a positive link with OA in patients vs. controls in the studied population (P=0.01). Serum resistin levels were not notably different between patient and control group (P=0.9). Further, the serum resistin level was not observed to be affected by -420 and +299 polymorphisms and no considerable differences were noted in resistin concentration in mutant vs. wild genotypes for both the studied genetic variations. OA is a complicated and multifactorial disease. Along with primary risk factors like age, gender or genetics, mechanical stress factor is also believed to influence the OA disease development and progression. Mechanical abnormalities in any tissue of the joint may be able to trigger the OA. Though, an exact mechanism of action of OA is not fully understood yet, experimental data suggested it may be initiated by some biochemical reaction in response to mechanical stress. The abnormal mechanical load on joint may induce an extensive biochemical response via mechanotransduction, a process which convert mechanical stress into biological signals, which leads to commencement or worsening of disease. A small pilot project was also carried out to investigate the changes in cytokines gene expression in the elderly human OA-cartilage in response to the mechanical stress. Cartilage explants were taken from OA patients during joint replacement surgery. These explants were subjected to cyclic load (2s on/2s off) via a custom made loading instrument and analyzed for changes in TNF-alpha and IL6 geneexpression level. Explants, not subjected to loading were taken as control samples. Real time PCR technique was used for the determination of gene expression. 18S rRNA housekeeping gene was used for normalization of the assay. Gene expression variations were observed in different samples. A significant down regulation in IL6 and TNF-alpha mRNA levels were observed (P<0.05). This current study concludes that there is a significant association between radiographic severity of the knee OA and clinical symptoms. An inverse relation between OA severity and QOL was also demonstrated. It also showed that TNF-alpha -308 G>A and -238 G>A, RETN -420 C>G and +299 G>A, and IL6 -572 G>C may have a role in the pathogenesis of the knee OA in a Pakistani population. A noteworthy down regulationwas also detected in cartilage TNF-alpha and IL6 mRNA expression level in response to mechanical stress stimulus in our pilot experiment.