متنی تنقید :
انسائیکلو پیڈیا ’ امریکانا ‘ نے متنی تنقید کی تعریف کرتے ہوئے لکھا ہے :
’’ متن کے اصل الفاظ کے تعین، اسے مکمل کرنے اور واقفیت واصلیت تلاش کرنے کی غرض سے پرانی تحریروں کے سائینٹفک مطالعے کو متنی تنقید کہتے ہیں۔ ‘‘
متنی تنقید کا اصل مقصد حتیٰ الامکان متن کو اصل روپ میں دوبارہ حاصل کرنا ہوتا ہے۔ اصل روپ سے مراد وہ شکل وصورت ہے جو متن کا مصنف اپنی تحریر کو دینا چاہتا تھا۔ یعنی اگر متنی نقاد کو مصنف کے ہاتھ کا لکھا ہوا نسخہ ملا ہے تو اسے متنی نقاد من وعن ہی شائع نہیں کرسکتا کیونکہ ممکن ہے مصنف سے کچھ الفاظ چھوٹ گئے ہوں یا کچھ الفاظ دوبارہ لکھ دئیے گئے ہوں یا اس قسم کی کوئی اور غلطی ہوئی ہو۔ ایسی صورت میں متنی نقاد کا فرض ہے کہ متن کو ان غلطیوں سے پاک کرے۔ متن کے لیے ضروری ہے کہ بامعنی ہو، اگر سینکڑوں برس کے عرصے میں نقل در نقل کی وجہ سے متن مسخ ہوگیا ہے تو اس کے اصل معنی کا تعین کیا جاسکے۔
متنی تنقید/تنقیدِ متن کے مدارج :
۱۔ تیاری ۲۔ مواد کی فراہمی
۳۔ متن کی تصحیح ۴۔ قیاسی تصحیح
۵۔ اعلیٰ تنقید
۱۔ تیاری :
الف۔مختلف عہد کے نسخے پڑھنا :
متنی نقاد کا فرض ہے کہ مختلف عہد کی تحریروں پر عبور حاصل کرنے کے لیے ان عہدوں کے نسخے پڑھے تاکہ تحریر کی شناخت کے ساتھ ساتھ اس عہد کے الفاظ وتحریر پر اسے عبور حاصل ہوسکے۔ متنی نقاد کو اس عہد سے قبل کے کچھ نسخے بھی پڑھنے چاہئیں۔ اس انتخاب کے باقاعدہ اصول تو نہیں ہیں لیکن اس عہد میں جولوگ ادب پر چھائے ہوں ان میں سے نمایاں لوگوں کو منتخب کرلیا جائے۔
ب۔مختلف عہد کی زبان پر عبور...
The examination of tax compliance expenses is becoming more relevant, revealing a complex challenge that involves both national and international fiscal policies. This matter is closely linked to tax evasion and avoidance, and its consequences could distort taxpayers' economic choices. Against this background, the study focuses on the impact of profit tax on the operational outcomes of the 'Fortalecida Abel Santamaría Cuadrado' Credit and Services Cooperative, which operates within the sugarcane sector in Camagüey, Cuba. The research uses both qualitative and quantitative methodologies to investigate this issue. The study aims to provide a detailed understanding of how tax compliance costs affect the cooperative in question by implementing a tripartite procedure that uses mathematical techniques and relative frequency analysis. A key finding from this investigation is the negative impact resulting from the exclusion of advance salary payments as deductible expenses in tax calculations. This finding highlights a critical area for fiscal policy reform as the policy oversight is identified as a source of financial strain for the cooperative. The implications of this discovery are far-reaching, indicating that similar cooperatives and businesses within Cuba (and possibly in comparable economic contexts) may also be experiencing analogous fiscal burdens.
Based on these insights, the study recommends the creation of customized methodologies to accurately measure tax compliance costs in the Cuban context. These methodologies should consider the distinctive socio-economic and regulatory features that define the Cuban economy, allowing for more precise evaluations of tax-related burdens on businesses. Furthermore, this research invites broader contemplation on the intersection of tax policy and business sustainability, particularly within sectors that are crucial to national economies but may be vulnerable to strict tax regimes. It emphasizes the need for a balanced approach to tax legislation that protects revenue interests without impeding economic vitality.
Diabetic foot infections (DFI) are a major complication of diabetes mellitus. It contributes to the development of gangrene and non-traumatic lower extremity amputations with the life time risk up to 25 %. Since bacteria responsible for chronic wound infections are commonly within polysaccharide matrices known as biofilms, which to a large extent are refractory to antibiotics even when the bacteria are genetically susceptible to their action. In the first part of the study, we identified the neuropathy, ulcer grade, microbial profile, phenotypic and genotypic resistance prevalence of methicillin and ESBL genes in bacterial isolates of DFI patients registered at PIMS, Pakistan. Our results indicated that 46 (92 %) out of 50 patients, had sensory neuropathy. The most prevelant isolate was Staphylococcus aureus (25 %), followed by Pseudomonas aeruginosa (18.18%), E. coli (16.16%), Streptococcus spp (15.15%), Enterococcus spp (9%), Proteus spp (15.15%) and Klebsiella pneumonia (3%). The prevalence of MecA gene was found to be 88 % and 84% phenotypically and genotypically respectively. K. pneumonia had highest percentage of ESBL producers with 66.6 % prevalence by double disc synergy test and 100 % for CTX+CL/CAZ+CL by combination disc test. Pseudomonas aeruginosa had highest (100 %) number of metalo β-lactamase producers by EDTA synergy disk test. Overall prevalence of bla-CTX-M, bla-CTX-M15, bla-TEM, bla-OXA and bla-SHV genes was found to be 76.92, 76.92, 75.0, 57.69 and 84.6 % respectively in gram negative isolates from DFI. Molecular epidemiology of MecA and ESBL genes were found alarmingly high in DFI, posing one of the major cause of antibiotic treatment failure. In the second part of our study we determined whether combinations of antibiotics and bacteriophage were more effective for the treating biofilm populations of Abstract xvii Pseudomonas aeruginosa [the laboratory strain PA14, and the clinical strain, CFBR2)] on plastic surfaces and layers of human epithelial cells. Two newly isolated bacteriophage NP1 and NP3 at a titer of ~1E8 pfu/ml were added individually or as pairs and/or in combination with 1X MIC, 4XMIC and 8X MIC of ceftazidime, colistin, gentamicin or trobramycin to 48 hours PA biofilms in 6 well polystyrene plates. Parallel experiments were performed with 8-hour biofilm populations of epithelial Naso pharyngeal Detroit 562 (ATCC® CCl-138TM). Treatment with phage reduces the viable density of biofilm populations of P. aeruginosa. biofilms by three orders of magnitude as compared to untreated control. In combination with antibiotics phages are more effective than alone and increase efficacy of the antibiotics for treating bacteria in biofilms. In the third part of study we explored co-evolutionary dynamics of resistance between Pseudomonas aeruginosa 14 and its phages NP1 and NP3. Evolutionary dynamics experiments of single and two phages revealed that PA14 can easily evolve resistance against NP1 phage. NP3 phage maintained for 30 serial transfers and we observed host range in evolved bacteria. In cocktail, both phage support each for their long term maintenance in serial transfer experiments. Also, cocktail delayed the evolution of resistance and sustained high phage infectivity, suggesting phage cocktail is promising strategy to control or slow down evolution of resistance in bacteria against bacteriophages.