The study aims to examine the role of personal and social determinants in order to predict psychological well-being: moderating role of resilience among flood victims. For this purpose a sample of 400 individuals (male, n = 200, female, n =200) who experienced flashy flood were selected through purposive sampling technique from the Province of the Punjab-Pakistan. The study was based on cross sectional survey design. For data collection five scales including Multidimensional Scale of Perceived Social Support, Meaning in Life Questionnaire, Religiosity Scale, Ego Resiliency Scale and Warwick-Edinburgh Mental Well-being Scale were utilized to examine the direct and indirect impact of social support, religiosity, and meaning in life on psychological well-being: moderating role of resilience among study population. Pearson correlation, Multiple Regression analysis and independent sample t-test were applied to test the hypotheses. Findings of the study revealed that social support, religiosity, and meaning in life significantly predicted psychological well-being: moderating role of resilience among the flood victims (p<.01). The study also confirmed the moderating role of resilience between the relationship of meaning in life, religiosity and social support with psychological well-being (p<.01) among flood victims. Gender differences revealed that female participants were significantly higher on social support, psychological well-being, (p<.01), meaning in life and religiosity (p<.05), whereas male participants were significantly higher on resilience (p<.05). The study explored the role of meaning in life, religiosity and social support in resilience and psychological well-being. The present nature of the study is very important to manage the problems of flood victims in the disaster areas of Pakistan and other developing of the countries as well. It will provide guideline to the policy makers, researchers, health practitioners and forthcoming students and may become the part of library. The similar nature of researchers should be conducted at large level to give recommendations to resolve the psychological stress by counseling of the flood victims through clinical settings practically. This psychological and social support will enhance the resilience and well-being among the flood victims.