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Home > Physiological Aspects of High Fat Diet Induced Metabolic Stress in Rats

Physiological Aspects of High Fat Diet Induced Metabolic Stress in Rats

Thesis Info

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Author

Mahmood, Aisha

Program

PhD

Institute

University of Agriculture

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Physiology

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/12422/1/Aisha%20Mahmood_Physiology_2019_UAF_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676724923006

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Diet has a great impact on human health. Consumption of high caloric diet (rich in fat) may lead to obesity and metabolic disorders associated with inflammation. High fat diet (HFD) is associated with epidemic development of metabolic disorders. It can trigger dysbiosis which, may lead towards cellular stress development by increasing intestinal epithelial permeability, inflammation and metabolic syndrome. Manifestation of gut associated metabolic disorders may be causally linked with numerous chronic diseases such as, Inflammatory Bowel Disease (Crohn’s disease, Ulcerative colitis), Inflammatory Bowel Syndrome, insulin resistance and ultimately cancer. However, the exact mechanisms underlying HFD induced obesity remained unexplored. Thus, the current research was planned to evaluate the effects of HFD on different physiological aspects, pathophysiology of gut and metabolic stress. For this purpose HFD (15% and 30% Margarine: Blue Band®) feeding was done in Wistar rats for a period of 6 weeks (42 days). Blood sampling were thus done for evaluating lipid profile, serum glucose concentration and other biochemical analysis. Tissue sampling was conducted during different intervals of the experimental period to perform histopathology, fat staining, immunohistochemistry, cellular ROS and gene expression analysis. The data was statistically analyzed by two-way ANOVA and DMR. Results revealed significant role of HFD in elevating body weight (147.71±9.50 g), serum cholesterol (63.55±1.71 mg/dl), LDL (28.81±2.92 mg/dl) and triglycerides (70.05±2.51 mg/dl) compared to control group having body weight (137.24±6.11 g), serum cholesterol (52.48±0.84 mg/dl), LDL (19.25±2.57 mg/dl) and triglycerides (55.76±2.89 mg/dl) respectively. The onset of inflammation was observed in response to HFD feeding even after a short time period in gut. Apparently, the induction was triggered by HFD mediated stress response. The role of cellular stress pathways and calcium is crucial in underlying mechanism of ROS production, as high expression levels of MAPK-8, Traf-4, Traf-6, Calm-2, Grk-2 and Pias-2 genes were detected in HFD treatment groups as compared to that of control group. High E.coli count due to HFD consumption also demonstrated its role in alteration of gut microbiota. Overall, HFD has a major effect on different aspects of intestinal physiology and it induces obesity which is accompanied by oxidative stress due to alteration of gut physiology.
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دل محمد دلشاد

دل محمد دلشاد (۱۸۰۰ء پ) گلی حکیماں محلہ سیداں (کوچہ بند) پسرور میں پیدا ہوئے۔ آپ اپنے فارسی اشعار میں ایک جگہ اس کی طرف اشارہ بھی کرتے ہیں :

یکے دو دست عجب تال آپس شش پہلو                        بشش جہات بہ پنجاب گو کہ ثانی آں است   

دلیل شادی دلشاد نام ایں شہراست                             کہ پر سرور طرب بخش عالم دل و جاں است  (۱۱)

آپ فارسی اور اردو کے بہترین شاعر ہونے کے علاوہ عالمِ دین بھی تھے۔ دلشاد کے کلام میں حد درجے کی پختگی اور سادگی عیاں ہے۔ وہ اپنی تشبیہات اور استعارے حالاتِ حاضرہ اور دیگر نشیب و فرازِ حیات سے اخذ کرتے ہیں۔ ان کے کلام میں بے حد جاذبیت اور شرینی موجزن ہے۔ اُن کا زیادہ کلام قصائد اور غزلیات پر مشتمل ہے۔

قاضی عطاء اﷲ اپنی کتاب ’’شعرائے پسرور‘‘ میں دلشاد کے بارے میں رقمطراز ہیں:

دل محمد دلشاد پسروری انیسویں صدی کے معروف فارسی اور اردو شاعر ہیں۔ آپ نے متداولہ علوم و فنون اغلباً سیالکوٹ جیسے علم و حکمت کے شہر سے حاصل کئے۔ منطق ‘ سلوک‘ اخلاق‘ فقہ اور شعری علم میں کمال حاصل کیا۔ (۱۲)

مذکورہ بالا علوم میں مہارت دلشاد کے ایک فارسی شعر سے واضح ہوتی ہے:

از علم شعر و منطق‘ فقہ و سلوک و اخلاص                    دارد تمام لیکن دلشاد زر نہ داد       (۱۳)

آپ کا زیادہ تر اردو کلام مفقود ہے۔ مختلف اردو تذکروں میں آپ کا کلام ملتا ہے۔ آپ کا فارسی دیوان ادارہ تحقیقاتِ پاکستان دانشگاہ پنجاب لاہور نے ۱۹۷۰ء میں شائع کیا۔ (۱۴) عشقِ مجازی‘ محبوب کی بے اعتنائی‘ بے وفائی‘ عشوہ وغمزہ وادا دلشاد کی اردو غزلوں کے موضوعات ہیں۔ حافظ محمود شیرانی نے اپنی تالیف ’’پنجاب میں اردو‘‘ میں دلشاد کی چند غزلیں نقل کی ہیں۔ ان اشعار میں دلشاد اپنے محبوب سے شکوہ کرتے نظر آتے ہیں۔ کلاسیکی اردو شاعری کے روایتی محبوب کی طرح...

ڈاكٹر حمید اللہ كی خدمت حدیث

Hadith is a verbal and practical interpretation of the Holy Quran and the second great source of Islamic jurisdiction. A misunderstanding about Hadith was propagated that it was compiled in the Third Century. The scholars of the sub-continent shook off those doubts raised against Hadith with lucid arguments. The personality who got the honour of writing on Hadith with intellectual evidence and deep research pattern was Dr. Hameed Ullah. Dr. Hameed Ullah proved with research that the work of compilation of Hadith started in the era of the Prophet (PBUH) and that of his companions (RA) . It further expanded in the era of the disciples ofthe Prophet's companions. This basic service ofHadith by these people strengthens the rule that compilation of Hadith was started in Prophet's era. The documents of the Prophet's reign and those of his companions and their disciples prove it that latter is a sufficient reply to reject the claims of those who don't trust in Hadith and those of the Orientalists that the writing of Hadith is the phenomenon two

Analyzing L1 Influence on the Acquisition of English Articles by Urdu Speakers: An Optimality Theoretic Account

English and Urdu differ in the way they express definiteness. English encodes (in)definiteness through a, the and Ø. Urdu, on the other hand, relies mainly on quasi indefinite article ek to show indefiniteness but definiteness of a noun is expressed in a context in which the noun occurs, through word order and also with the help of thematic roles the noun plays in the argument structure. Keeping in mind the variations between the two languages, the main objective of the study is to examine the role of L1 along with other troublesome sources in the acquisition of English articles by Urdu L2ers of English. For this purpose, the data was collected from 41 undergraduates at Department of English in UAJ&K, comprising of two sets. The data set one was gathered in the form of 41 written composition and 10 speech production from the learners. For the second set of data, the same group of participant was tested via Master’s (1994) article diagnostic test with the interval of two years. Apace with, the learners’ improvement in general English proficiency during these years is measured employing different versions of the Oxford Quick Placement Test (OQPT).Using Huebner’s (1983) classification system, the data set two was analyzed quantitatively. First, by employing MINITAB 14, the use of articles in different item/noun environments is investigated. Then, the sequence/order of article acquisition is determined with regard to the SOC (Supplied in Obligatory Contexts), TLU (Target Like Use), and UOC (Used in Obligatory Contexts) measures. The results of the first set of data report article errors as the most persistent problems in the writing and speech of Urdu L2ers of English. The study reveals L1 transfer effects as omission of a was less than the omission of the in the data. Whereas, the unnecessary insertion of the is viewed as an intralingual error. The results have spotted English generic context as the most problematic area of difficulty for the learners. The study finds the learners’ better performance in sentence level generics. For further details, the overgeneralization of the is observed with mass and plural nouns. The study puts forth that the learners associate the initially with [+SR] features instead of [-SR] features. Above all, (a > the > Ø) route of article acquisition is determined for Urdu L2ers of English. Finally, employing Optimality theoretic Syntax account, it is shown that learning the ranking of FDEF over *FunctN, and then of (Num)= ¯ SG – FunctN over *Def/[Fam] is hard to acquire by the learners.