Dengue, an arboviral disease has become endemic in South East Asia since the last two to three decades. The research information presented in this thesis was conducted in the metropolitan city of Lahore, Pakistan, from 2011 to 2013. The research was focused on entomological, viral and epidemiological surveillance of dengue, the mosquito vector responsible for transmission of dengue viruses being Aedes aegypti (Ae. aegypti). Indoor entomological surveillance was carried out on the basis of Ovitrap Index (OI) for larval and Per Man Hour Density (PMHD) for adult vectors while Outdoors entomological surveillance was done by OI in eight parks in the city of Lahore, exhibiting different ecological/environmental factors. Viral surveillance in adult vectors to find out their infectivity was based on Minimum Infection Rate (MIR). The study area was five randomly selected Union Councils (UCs) from each of the nine towns and one Cantonment Board (CB) of the city. In addition to that, Knowledge, attitude and practices (KAP) study was carried out to assess the community perception regarding dengue epidemic. Correlation between dengue patients and OI, PMHD, MIR and climatic conditions (temperature, humidity and rainfall) was established by using statistical software, SPSS, version 19, while Panel Data Analysis was carried out for dengue prediction by Fixed Effect (FE), Random Effect (RE) Model and Hausman Test, using STATA software, version 11. The survey of indoor larval density revealed that OI, PMHD and MIR values were maximum in late rainy season (33-38 week) in 2011, whereas in 2012 these values were maximum in early post rainy season (38-45 week), except for MIR. However, in 2013, maximum values were obtained in early post rainy season. On the other hand, minimum OI, PMHD and MIR were recorded in late post rainy season (45-52 week) for all the three years. Outdoor Entomological Surveillance in parks revealed that maximum OI was in late rainy season and minimum in late post rainy season, for the years 2011, 2012 and 2013. MIR in adult mosquitoes was higher than human beings, which suggests that mosquitoes may serve as a mode for maintenance of the virus and when levels of immunity to a certain serotype decreases, dengue infection may emerge. In parks, ovitraps were positive where placed close to water channels, shades and residences. Epidemiological survey revealed that the patients in the age range of 31- 45 years were the most in early post-rainy season, followed by late rainy season in all towns. Infected males were almost twice in number than females. Majority of the patients were laborers and professionals, followed by students and housewives. Educational status of a majority of the patients was up to primary or secondary school level, while very few were college graduates. Monthly income of majority of the patients was < 15000 rupees. Majority of the respondents had fair knowledge concerning the dengue vector and knew that the fever was transmitted by and is not contagious. Correlations between entomological surveillance indices (OI, PMHD, MIR) and dengue patients were significant at p value of 0.01, while correlation of dengue patients with climatic factors (temperature, humidity and rainfall) was mostly insignificant at pvalue level of 0.01. Knowledge, Attitude and Practices of dengue disease, its transmission and control were positively associated with age, education level, marital status and occupation. Status of esknowledge was found to have a significant relationship with age (F = 7.57, p 0.001), gender (F = 4.14, p < 0.01),occupation (F = 9.01, p < 0.001), transmission of viruses (F = 5.29, p < 0.001), breeding sites of the mosquito (F = 4.47, p < 0.01), time of mosquito biting (F = 4.62, p < 0.001), and measures to be adopted for preventing mosquito bites (F = 2.25, p < 0.05). Significant relationship (p < 0.001) was also discovered in the attitude and practices of people in adopting preventive measures for dengue. The study revealed that all variables, such as PMHD, relative humidity and rainfall had a significant effect (z value < 0.1), whereas temperature and MIR had no impact (z value > 0.1) on dengue patients. It is concluded from the results of FE model that if PMHD, MIR, temperature and relative humidity increase by 10 units, the number of dengue patients will increase by the factor of 4.22, 9.26, 2.80 and 5.8, respectively, whereas if rainfall increases by 10 mm, number of dengue patients would decrease by 1 in number. Results of RE model showed that if PMHD, MIR, temperature and relative humidity is increased by 10 units, number of dengue patients will respectively increase by 4.01, 15.88, 3.10. and 5.73, while if rainfall is increased by 10 mm, number of dengue patients would decrease by -1.01. This study provided the early prediction model which could be made part of an early warning system for the prevention of dengue outbreak. For comprehensive control and prevention of dengue, it is also recommended that information about all aspects of disease in general and surveillance in particular should be included in curricula at the school and college level. Additional entomological/ epidemiological Indices/parameters should be added to the prevailingmethods to increase the effectiveness of dengue vector surveillance.
مسلسل جدوجہد کا میابی کی کنجی ہے ایک بچہ ہاتھ میں کتابوں سے بھرا بیگ اٹھائے خراماں خراماں گاؤں کے مشرقی کونے پر موجود سکول کی جانب جارہا تھا۔ چہرے پر بشاشت کے آثار نمایاں تھے۔ کسی منزل پر پہنچنے کا شوق دامن گیرتھا، اپنے بوڑھے والدین اور بہن بھائیوں کی خدمت کا جذ بہ بھی پیش نظر تھا۔ یہی شوقِ تعلیم اس کو اپنے مقصد کی تکمیل کے لیے ممدو معاون ثابت ہوسکتا تھا۔ اس کے شب و روز حصول مقصد کی لگن میں گزررہے تھے۔ دریں اثناء اچانک جاں گسل صدمہ پیش آیا اور اس کے ارمانوں پر پانی پھیر گیا۔ آفت آسمانی سیلاب کی صورت میں اس کے گھر کو قبرستان بنا کر چلی گئی۔ اور گھر کا جملہ سامان عذاب کی صورت میں آنے والے سیلاب نے ختم کر دیا۔ اپنی اس گفتگو کے دوران اس کی آنکھوں میں آنسوؤں کی شکل میں نمی کے آثار نمایاں تھے۔ عظیم منصب پر فائز شخص نے موونگ چئیر پراپنے جسم کو دائیں بائیں متحرک کرتے ہوئے اپنی کامیابی کے راز کو فاش کیا اور کہا کہ شوق اگر چہ کا میابی کے لیے یوں ہے جیسے مچھلی کے لیے پانی ، زندہ رہنے کے لیے خوراک، اور سانس لینے کے لیے ہوا، لیکن شوق کے ساتھ محنت اور مشقت نہ اٹھائی جائے تو صرف شوق بلبلہ بر آب ثابت ہوگا۔ حدیث نبوی صلی اللہ علیہ و آلہٖ وسلم ہے کہ استقامت کرامت سے بھی بڑھ کر ہے۔ ایک شخص محنت شاقہ کا بارگراں اُٹھاتا ہے لیکن اس میں بے قاعدگی کا عنصر موجود ہے، باقاعدگی اور تسلسل کا فقدان ہے تو اس کی محنت رنگ نہیں لائے گی ، اس کے گلشن میں بہارنہیں آئے گی، اس کے کھیت و کھلیان کشتِ زعفران کا نمونہ پیش نہیں کریں گے، اس کے طائران خوش الحان...
It is generally perceived in contemporary intellectual movements that canonical Traditionalists did not take hadth text into consideration as their scholarly efforts were limited to the evaluation of hadth chains. Aforementioned notion - in my opinion - originates from shallow study of methodology adopted by canonical hadth critics، as a deeper look into their scholarly works reveals that sciences of hadth includes the authentication and disparagement of traditions as well as comprehension and deduction from hadth content. The sole objective of early Traditionalists from transmission، collection of hadth، its evaluation، authentication and disparagement was to safeguard the true meaning of Sunnah and to transmit it in its pure form to the successors. In fact the peculiarity of their work is that they exert all efforts in order to deal with hadth as a single undivided whole، where examination of content was not irrelevant to the evaluation of chain، their conscientious efforts recorded in major works of hadth show how they evaluated content of hadth to determine that it was not contradictory to Shari‘ah، or with another sound tradition، as there was a possibility that a certain reliable reporter made mistake or speculated in transmitting the meaning of hadth. Therefore we witness them disparaging a certain transmitter for his negligence and errors whereas his hadth is forsaken، moreover they would not consider him a Traditionalists or muhaddithn if excessive speculations were found in his report. This research paper aims at investigating the aforementioned hypothesis.
Results of the numerical study on the initial formation stages of low-mass protostellar systems leading to single, binary, triplet, and quadruple protostar systems formation are reported here. In addition to these various types of protostellar objects we also investigate the overall structure formation that takes place within collapsing molecular cores that yield during the course of evolution the spiral structure formation, ring formation, and bar formation under various initial conditions chosen for a rotating solar mass cloud of molecular hydrogen to mimic the states prevailing in star formation regions in our Milky Way galaxy. There have been three key parameters belonging to the initial star forming conditions whose effects on the overall outcome of protostallar systems have been examined. These parameters are the initial thermal state of the prestellar core, the amplitude of azimuthal density perturbation introduced in initially uniform density state of the core, and the impact of the critical density which governs the transition from isothermal to adiabatic thermodynamic behavior of the collapsing core. For protostellar binaries, the separation is determined as a function of the initial thermal state of the core by varying its initial temperature. For this purpose a slightly modified version of the Burkert and Bodenheimer collapse test is taken into consideration. We find that the result is fairly sensitive to both the initial thermal state of the cloud and the initial azimuthal density perturbation’s amplitude A. For A=10 %, variations of only 1 unit Kelvin below 10 K causes a change of up to 100 AU in protobinary separation, while for this small amplitude of perturbation the initial temperatures above 10 K result a single low-mass fragment, instead of a binary, that does not reach even near to the protostellar densities. However, protostellar binaries, do appear if the amplitude of perturbation is enhanced from 10 % to 25 %. A star forming hydrogen gas is normally considered to be initially at 10 K. For structural formation study, we have explored that an oscillation around this normally considered value can be influential in determining the fate of a collapsing gas as it evolves in its structural properties that may lead to formation of proto-stars. We examined the initial range of temperature of star forming gas between 8 K to 12 K and tried to compare the emerging physical properties within the early phase of formation of protostellar system. According to our findings the spiral structures are likely to appear in a strongly perturbed molecular cores that commence their phase of collapse from temperatures lesser than 10 K. However, cores with initial temperatures more than 10 K potentially develop, instead of spiral, a ring structure which afterwards experiences the clumps formation. It is possible to observe a transition from spiral to ring instability at a typical initial core temperature of 10 K. Similarly, while investigating the effects of critical density variations on the evolution of protostellar systems, we find that the critical density affects the structural evolution of the envelope of gas, also the dimension of emerging rotating disk structures during collapse too get affected as well as the number of fragments appearing from the concluding fragmentation of the disks. It is suggested that this mechanism has the potential to give birth to young protostellar objects that may eventually constitute systems of bound multiple protostars. The entire numerical experiment is conducted by using 250025 SPH particles to construct virtually the geometry of each molecular core investigated here.