خان بہادر مولوی بشیر الدین
افسوس ہے کہ اسی مہینہ تعلیم ِجدید کی ایک نامور شخصیت نے بھی داغ مفارقت دیا۔خان بہادر مولوی بشیر الدین، سرسید اوران کے رفقاء کے عہد کی یادگار تھے۔انتہاء درجہ مخلص،مسلمانوں کادرد رکھنے والے،پرلے درجے کے نیشنلسٹ، کٹر مذہبی اور دین دار، انتھک اورخاموشی کے ساتھ نہایت ٹھوس اور تعمیری کام کرنے والے۔یہ سب اوصاف و کمالات کسی ایک شخص میں مشکل سے ہی جمع ہوسکتے ہیں لیکن قدرت نے مرحوم کی ذات میں یہ سب اوصاف وکمالات بیک وقت جمع کردیے تھے۔ان کا اٹاوہ ہائی اسکول جواب ڈگری کالج ہے صرف اترپردیش کانہیں بلکہ پورے ہندوستان کاایک مثالی اسلامیہ ہائی اسکول تھا جس نے سینکڑوں بڑے بڑے اورنامور مسلمان پیداکیے۔اس اسکول کی سب سے بڑی خصوصیت یہ تھی کہ عمدہ اوربہترین تعلیم کے ساتھ اسلامی تربیت کا بھی خاص طور پر خیال رکھا جاتا تھا اوراسکول اوربورڈنگ کے اخراجات اس درجہ کم تھے کہ تھوڑی آمدنی رکھنے والے والدین بھی اپنے بچوں کویہاں بڑی آسانی اورسہولت کے ساتھ تعلیم دلا سکتے تھے۔مرحوم نے کافی عمر پائی۔سو سال سے زیادہ کی عمر میں وفات ہوئی۔سالہا سال سے بالکل معذور ہوگئے تھے لیکن وضع میں ذرافرق نہیں آیا۔ان کااخبار ’البشیر‘ بھی برابر جاری رہا اوراسکول کی ترقی کے خیال سے وہ کبھی سبکدوش نہیں ہوئے۔اﷲ تعالیٰ جنت الفردوس میں ان کو جگہ عطافرمائے اورمسلمانوں کوتوفیق دے کہ وہ ان کی یادگار کونہ صرف یہ کہ باقی رکھیں بلکہ اور اس کو ترقی دیں۔ [جولائی۱۹۵۶ء]
Current scenario of newer diseases with multiple causes has drawn the attention of the researchers in the field of therapeutics and they are now inclined to identify molecules effective for targeted therapy. Objective: Quinoline (1-azanaphthalene); belongs to heterocyclic aromatic nitrogen compound. Some quinoline-based derivatives are also known for their anti-tumor activity. The study was planned to evaluate the cytotoxic potential of quinoline derivatives. Methods: Berberine; a quinoline compound was made part of study to make structural analogs which were docked against potential target proteins. Cytotoxic profiling of all derivatives was done using MTT cytotoxicity assay. Results: The pharmacoinformatic and structure activity relationship studies of analogs were done. The cytotoxic profiles were elucidated by comparing viability rates of analogs treated hepatic cancerous cell line with untreated hepatic cells and untreated mesenchymal stem cells as standards. Marked cytotoxicity was seen in all molecules at low doses than reported in past studies with relevance to parent compound. Conclusions: The results will be further confirmed through various other cell culture assays targeting different marker proteins, pharmacoinformatics tools and structure activity relationship studies
Today a good personnel management is the most important competitive factor for any business organization. Personnel management is an extension to the general management and is concerned with manpower planning, acquisition of competent workforce, their performance appraisal, training and development and compensating them and have good relations with them to make their fullest contribution to the organization. In a highly competitive environment of today‟s business, ignoring cultural and religious issues in people management is committing corporative suicidal. The purpose of this research thesis is to explore the nature and contents of personnel management in Islamic perspective. Present research thesis is designed to answer questions such as; do Islamic teachings offer relevant perspectives on personnel management issues? Are the treatments of personnel management issues in Islam compatible with evolving organizational concepts? The present research is aimed at developing a conceptual framework of personnel management based on the Islamic principles, not only to ensure success in the running of the business but at the same time making sure that the moral and ethical values of Islam are observed. It addresses the modern issues of personnel management in line with early Islamic instructions. The research work is conceptual and theoretical in nature. A qualitative approach based on extensive review of relevant literature and the employment of examples from Islamic history has been used in this research thesis. It should be mentioned that this research does not intend to show any empirical findings but it endeavours to look into the original sources of Islam while extracting other sources of the modern approach of management. It is tried to survey Islamic texts and treaties then compare Islamic instructions to what is prevailing in business organizations today. As a result the fundamental functions of personnel management are discussed according to the socio-economic fabrics of Islam whose suitability is relevant for modern day business operations. This research promises to open new avenues to understanding personnel management issues in Islamic societies and organizations working under the influence of Islamic instructions.