طہارت و نظافت کا اصول
اسلام زندگی بسرکرنے کے ہر پہلو کے متعلق ہدایات و احکام کا جامع تصور دیتا ہے۔ اسلام میں پاک و صاف وسائل ِ حیات کے استعمال کی ترغیب دی گئی ہے۔ اسلام میں طہارت و نظافت کے معاملے میں انتہائی مثالی تعلیمات و ہدایات بیان کی گئی ہیں۔ اسلام آلودگی و گندگی سے نفرت اور صفائی و پاکیزگی سے محبت کا جذبہ پیدا کرتا ہے۔ اصول ِ طہارت پر عمل کرنا حکم الہی ہے۔ طہارت کے اصول کی پیروی سے انسان فکری پاکیزگی حاصل کرتا ہے۔ اگر کوئی انسان اپنے نفس کو پاکیزہ رکھنا چاہتا ہے تو اسے لا محالہ طہارت کے اصول پر عمل کو اپنی اولین خصلت بنا نا ہوگا۔ طہارت کے اہتمام سے انسانی قلب و رووح میں نورانیت پیدا ہو جاتی ہے۔ فقہ اسلامی کی ہر کتاب کا آغاز کتاب "کتاب الطھارۃ "کیا جاتا ہے۔ شاہ ولی اللہ ؒ نے حجتہ اللہ البالغہ میں طہارت و نظافت کے اصول پر تفصیلی اور فکر انگیز روشنی ڈالی ہے اور اصول ِ طہارت کو اساسیاتِ اخلاق کے اولین درجے پر فائز کیا ہے۔ اصول طہارت کی پیروی انسانی فطرت کا خاصہ ہے۔
علامہ راغب اصفہانی کے مطابق طہارت کی دواقسام ہیں:
" والطَّهَارَةُ ضربان: طَهَارَةُ جسمٍ، وطَهَارَةُ نفسٍ، وحمل عليهما عامّة الآيات"[1]
طہارت کی دو قسمیں ہیں: 1۔ جسمانی و ظاہری طہارت 2۔ قلبی و باطنی طہارت قرآنی آیات میں جہاں بھی طہارت کا ذکر کیا گیا ہے، وہاں یہ دونوں قسم کی طہارت و نظافت پر عمل کرنا مراد ہوتاہے۔ امام بخاری ؒ نے صیح بخاری کا آغاز نیت کے اخلاص یعنی قلبی پاکیزگی سے کیا ہے۔ یعنی دل کی صفائی کو جسم کی صفائی پر فوقیت و برتری حاصل ہے۔
قرآن...
"Mishkāt al-Maṣābīḥ" has a sound rank among the Hadith collections. Its importance can be gauged from the fact that it has been described and summarized by several scholars. The works of Sheikh Abdul Haq Muḥaddith Dehlavi over that is a great contribution and have a special place in the context of his Hadith services. He is one of the prominent muhaddithin of the Subcontinent. He was pioneer in teaching and disseminating Hadith knowledge in the subcontinent. Firstly, he described the Mishkāt al-Maṣābīḥ in the Persian language of that time, which gained immense popularity among the people and increased the taste for understanding Hadith. Secondly, He accumulated a treasure trove of mysteries and secrets in Arabic for the use of Researchers. The name of the Persian commentary is Ash‘atul Lam‘āt while the Arabic commentary is called Lam‘āt al-Tanqīh. They are more than one in usefulness, which has created a taste for reading and understanding Hadith among the people and Researchers. In the said article, an introduction and methodological study of the work done by Sheikh Abdul Haq on Mishkāt al-Maṣābīḥ will be presented.
Toll-like receptors (TLRs) are a family of type I transmembrane pattern recognition receptors
(PRRs) that play a critical role in the innate immune system. They recognize specific molecular
patterns from a wide variety of pathogens and initiate a signaling cascade that mobilizes the
appropriate host defense. They are usually expressed on membrane of various subclasses of
immune and non-immune cells such as macrophages, monocytes, dendritic cells, neutrophils,
T-cells, B-cells, epithelial, endothelial and fibroblasts. In the present study, the genetic
polymorphisms in Toll-like receptors 2 (TLR2) gene was investigated in indigenous cattle breeds
Achai and Lohani of Khyber Pakhtoon Khawa (KPK) province of Pakistan. The complete
sequences of TLR2 gene composed of 5?UTR 136bp, coding sequence 2355bp and 3?UTR 1316
bp. The distribution of polymorphisms was explored in the coding region of TLR2 gene in
studied two cattle breeds. The phylogenetic analysis was performed on the basis of coding region
of TLR2 gene showed that the Bos indicus, Bos taurus as the nearest neighbors with other species
bubalus bubalis, Bos frontalis, Bos grunniens, and Bison bison. The Ovis aries and Capra hircus
in a separate group with Capra ibex, Antidorcas marsupialis, Damaliscus pygargus and the
chicken (Gallus gallus) was found to be the farthest specie. The ratio of dS/dN substitutions was
<1 at polymorphic-sites indicating purifying selection. A total of seven polymorphisms were
detected in Achai cattle breed, in which two variations were synonymous and five mutations
were non-synonymous. In the analysis, four polymorphisms were transitions type mutations
and three were transversion. The amino acid [aa] sequences analysis of the coding region (784
aa) revealed extracellular domain composed of 20 leucine-rich repeats (LRRs), trans membrane
and Toll-IL receptor domains. A total of four mutations were observed in Extracellular domain,
one in transmembrane domain, and two in TIR domain of TLR-2 protein in Achai cattle breed.
The Lohani cattle breed was more polymorphic at TLR2 gene and a total of 41 polymorphisms
were detected including 20 variations were synonymous and 21 were identified non-synonymous.
Similarly, the amino acid [aa] sequences analysis of the coding region (784 aa) revealed
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extracellular domain composed of 20 LRRs, trans membrane and Toll-IL receptor domains. A
total of 25 polymorphisms were observed in the Extracellular domain, four in transmembrane
domain and five in TIR domain, one in signal peptide. The predicted bovine TLR2 is a succulent
like having energetic sites buried inside the concave side and forming a pocket for
ligand-binding. The present study findings show that the variation may be associated with
pathogens associated molecular pattern (PAMPs) mediated differential TLR-signaling of bovine
immune response and could regulate the consequence of infection