The purpose of the present research was to examine the relationship between work family conflict and its directions with work and non-work outcomes. The study also examined the moderating role of social support and gender in relation between work family conflict (i.e., work-interference-with family and family-interference-with work) and outcomes. The research was conducted in two distinct studies; Study I (N= 216) was aimed at addressing the psychometric properties of the instruments in local context and Study II was main study (N= 366) which aimed at testing hypotheses formulated for the present research. The sample for both the studies was drawn purposively from financial institution, telecom and health sector organizations of Rawalpindi and Islamabad. Instruments included Work Family Conflict Scale (Carlson, Kacmar, & Williams, 2000), Perceived Social Support Scale (Caplan, Cobb, French, Harrison, & Pinneau, 1975), General Job Satisfaction Scale (Hackman & Oldham, 1975), Turnover Intention Scale (O’Driscoll & Beehr, 1994), Satisfaction with Life Scale (Diener, Emmons, Larsen, & Griffin, 1985), and ENRICH Marital Satisfaction Subscale (Fowers & Olson, 1993). The results of Study I revealed fair to good model fit for study variables. Reliability estimates also provided fair to satisfactory internal consistency evidences for the instruments used. Results of Study II found that Work family conflict was significantly negatively correlated with Job satisfaction and Marital Satisfaction as an outcome variable. The relationship was negative for Turnover Intention. Work-interference-with family did not correlate with Job Satisfaction and Turnover Intention. Family-interference-with Work was significantly negatively correlated with Marital Satisfaction. Among the work-related sources of support, supervisor support moderated the relation between workinterference- with family and job satisfaction as well as turnover intention. Coworker support also moderated the relation between work-interference-with family and job satisfaction as well as turnover intention. Spousal and friend support did not appear to moderate the relation between family-interference-with work and marital satisfaction as well as family social support also appeared to be nonsignificant moderator between family-interference-with work and marital satisfaction. Gender was a significant moderator between work-interference-with family and turnover intentions. Gender fails to moderate the relation between work-interference-with family and job satisfaction as well as family-interference-with work and marital satisfaction. It was also found out that work-interference-with family is more strongly felt as compare to family-interference-with work. Significant gender differences showed that women feel more of work family conflict as well as family-interference-with work than men, although there was nonsignificant difference on direction of work-interference-with family. The results of the present research are discussed in the light of relevant literature for future implication.
پروفیسر سید ضیاء الحسن ندوی سخت افسوس ہے کہ پروفیسر سید ضیاء الحسن ندوی ۲۰؍ جنوری ۲۰۰۳ء کو حرکت قلب بند ہو جانے سے وفات پاگئے، اناﷲ وانا الیہ راجعون، وہ دارالعلوم ندۃالعلما کے بڑے لایق اور ہونہار فرزندوں میں تھے، ندوہ سے فراغت کے بعد انہوں نے جدید تعلیم حاصل کی پھر جامعہ ملیہ اسلامیہ کے شعبہ عربی میں لکچرر ہوئے اور ترقی کر کے پروفیسر اور صدر شعبہ ہوئے، اس وقت فیکلٹی آف ہیو مینٹیز اینڈ لینگویجز کے ڈین بھی تھے، جدید اور ماڈرن عربی میں ان کو مکمل دست گاہ تھی، ’’مہجری ادب‘‘ پر ان کی ایک کتاب بھی شایع ہوئی ہے اور بیرون ملک کے جراید و رسائل میں ان کے مضامین بھی چھپتے تھے، عربی زبان پر اچھی قدرت ہی کی وجہ سے انڈین کونسل فارکلچرل ریلیشنس کے سہ ماہی عربی رسالہ ثقافتہ الھند کے اڈیٹر مقرر کیے گئے تھے اور اس کا ایک ضخیم اور شان دار نمبر مولانا سید ابوالحسن علی ندوی پر نکالا تھا۔ مولانا علی میاں اور دارالعلوم ندوۃالعلما سے ان کا بڑا گہرا تعلق تھا، دارالعلوم کے کاموں میں نہایت سرگرم اور پیش پیش رہتے تھے، اس کی مختلف کمیٹیوں کے ممبر بھی تھے، عالمی رابطہ ادب اسلامی کے بھی رکن تھے، اس کے اجلاس میں بڑے شوق اور دلچسپی سے شریک ہوتے تھے اور اس کے لیے متعدد بیرونی ملکوں میں بھی تشریف لے گئے، مولانا سید محمد رابع ندوی ناظم ندوۃالعلما کو ان پر بڑا اعتماد تھا، ان سے اور ان کے چھوٹے بھائی مولانا سید محمد واضح ندوی سے بہت گھلے ملے رہتے تھے، علمی صلاحیتوں کے ساتھ ان میں انتظامی خوبیاں بھی تھی۔ مرحوم بڑے مرنجاں مرنج، وسیع المشرب اور طبعاً شریف اور خوش مزاج تھے، ہر ایک سے خندہ روئی سے ملتے، اپنی نیکی، وضع داری، اخلاص اور علم دوستی کی بنا...
This paper is an attempt to elaborate and highlight the attributes and qualities of leading specialists and reformative factors of Islamic society blessed with moral par-excellence known asṢūfiyā and‘Ulamā’. As unfortunately, with an exception of few, these responsible characters have gone astray following ill commanding self like a wolf in sheep’s dress hiding their harmful aspects with friendly appearance. These so-called knowledge spreading elements and spiritual mentors are also accountable to disparage the values and thought associated with Islamic system of learning and self-purification. So, it is necessary to remove the curtain in order to visit the real picture of Taṣawwaf. For this purpose, a book ‘Kashf al-Maḥjūb’ of great Sufi scholar Syed Alī bin ‘Uthmān al Hujvairī (R.A)has been selected to examine analytically how he discussed the situation in the light of Qur’ān and Sunnah elaborating the misconduct and bad behavior of under discussed. One who disguised himself instead of having conflict between his internality (self) to that of externality. The habits and attitude of imperfect Ṣūfiyā and the misleading ‘Ulamā’ and their injurious impact on society have been discussed by Alī Hujvairī (R.A) in his comprehensive treatise. The author also setout a strategy to know how to get rid of these so-called Ṣūfiyā and‘Ulamā’ and suggested various outlines and framework for recuperation in order to save the humanity from their lethal side effects.
Purpose of the study The objective of current research work was to develop and evaluate microspheres for controlled drug delivery. These pH dependent polymeric microspheres were designed to deliver drug in a controlled release fashion, to minimize dosing frequency, to increase bioavailability and minimize drug toxicity. Methodologies In this study various polymeric microsphere formulations were prepared using methacrylate derivatives and ethyl cellulose (EC) by oil-in-oil (O/O) solvent evaporation method. Span 80 was used as an emulsifier. Ivabradine HCl (IBH), anti-anginal was used as a model drug. IBH was encapsulated into microspheres by in-situ method in all formulations. A series of formulations with three different polymeric combinations i.e., eudragit L100-55-EC (Formulation code FA1-FA7), eudragit FS30D-EC (formulation codes FB1-FB7) and Kollicoat MAE 100P-EC (formulations codes FC1-FC7) were developed. Prepared microspheres of all formulations were characterized by recovery of microspheres, percentage yield, percentage drug loading, encapsulation efficiency and swelling studies. Optical and scanning electron microscopy (SEM) was used to examine the morphology and size of microspheres. Particle size distribution analysis was performed by Zetasizer. Rheological properties were conducted to measure the flow properties of resultant microspheres. Chemical stability of IBH loaded microspheres was confirmed by fourier transform infrared spectroscopy (FTIR), x-ray diffractometry (X-RD), differential scanning calorimetery (DSC) and thermal gravimetric analysis (TGA). In-vitro drug release studies were performed in phosphate buffer solution of pH 1.2, 5.5, 6.0 and 7.4. On the basis of results of in-vitro dissolution studies optimized formulations (FA7, FB7 and FC7) were selected for in-vivo studies on rabbits. Results and Discussion All formulations were synthesized and characterized successfully. Rheological studies showed that the formed microspheres were free flowing in nature. SEM images confirmed that resultant microspheres were spherical and smooth surfaces. SEM images showed that microspheres were in the size range of 20-80 μm with spherical shape. Zeta size analysis showed all formulation were in micromeritic range with narrow size distribution. FTIR spectra confirmed the presence of drug in pure form and reflected no interaction between drug and polymers. DSC and X-RD xx determined that the nature of drug in drug-loaded microspheres was in amorphous form. X-RD clearly indicated that drug particles were uniformly distributed in the polymeric matrix. TGA indicated that prepared microspheres showed much better thermal stability than pure drug. The microspheres executed pH dependent swelling behavior. The Maximum percentage entrapment efficiency of IBH was found upto 81 ± 2.15, 45.1% and 82 ± 2.11 for developed microspheres of eudragit L100-55-EC, eudragit FS30D-EC and Kollicoat MAE100P-EC respectively. Maximum percentage yield of eudragit L100-55-EC, eudragit FS30D-EC and Kollicoat MAE100P-EC microspheres was found 88± 2.65, 71.66 ± 2.12 % and 89 ± 3.31 respectively. In-vitro studies revealed that all formulations (FA1-FA7, FB1-FB7 and FCI-FC7) showed pH responsive drug release. All polymeric carrier presented negligible cumulative drug release in buffer solution of pH 1.2. The Maximum drug release 94.5%, 95.9% and 90% of optimised formulation (FA7, FB7 and FC7) was observed at pH 7.4 which demonstrated that all formulations had a pH-dependent drug release. Maximum controlled release effect was observed in formulations (FA7, FB7 and FC7) containing 50:50 of eudragit and EC due to reduction in swelling of microspheres. Results showed that high concentration of EC results in a longer diffusional path length, so drug release is extended and drug release mechanism gradually transfer from diffusion to erosion. Cumulative drug release data of all formulations were analyzed by using different kinetic models. The result showed that first order was best fit to the data and followed by drug release. By applying Korsmeyer-peppas model the value of (n) for release of drug was calculated. The value of (n) was found between 0.435- 0.830 which indicates that diffusion mechanism was non-fickian. High-performance liquid chromatographic (HPLC) method was developed and validated for analysis of IBH in mobile phase and rabbit plasma as per ICH-guidelines. The separation was performed on HSC18 (25 cm x 4.6 mm, 5μm) column with Acetonitrile: Buffer pH 6.0), 40:60 v/v) as mobile phase and a flow rate of 1.0 ml/min in the isocratic mode. A well-defined chromatographic peak of IBH was exhibited with a retention time of 4.062 minutes and tailing factor of 1.658.The linear regression analysis data for calibration plots showed good linear relationship with R=0.9998 in the concentration range of 1.56-100 μg/ml both in mobile phase and in plasma. The method was validated for precision, recovery and robustness. Intra and inter-day precision were less than 2%. The method showed the mean recovery of 96% to 102% and relative standard deviation (RSD) < 1% in Mobile phase and rabbit plasma. HPLC method was found to be highly precise, sensitive and accurate for determination of IBH in xxi pharmaceutical dosage form successfully applied to the commercial tablets without any interference of excipients. Optimized polymeric formulations were selected on the basis of in-vitro results and further studied for biological evaluation in rabbits in order to validate their effectiveness up to a considerable extent. After administration of single oral dose of drug solution and selected microspheres were subjected to in-vivo studies to calculate pharmacokinetics parameters. Pharmacokinetic parameters (pk) were calculated by Phoenix WinNonLin® Version 6.3 software the linear trapezoidal method was used to calculate AUC from time versus plasma concentration. All the polymeric microspheres (FA7, FB7 and F7C) had significantly prolonged Tmax, mean residence time (MRT), lower maximum plasma drug concentration (Cmax) had higher area under curve (AUC) in comparison to oral drug solution. Statistical analysis was performed by using one-way analysis of variance (ANOVA) in order to determine statistical significant and non-significant interpretation. The P value was < 0.05 which indicates a significant difference in results. Conclusion In short, pH dependent polymeric carriers; eudragit L100-55-EC, eudragit FS30D-EC and Kollicoat MAE100P-EC microspheres having potential to release drug in a controlled fashion, have been developed successfully. The results of in-vitro and in-vivo studies confirmed that microspheres entrapped IBH and prolonged its pharmacological effects due to increase of biological half-life. Collectively, these in-vivo results manifested that pH-dependent microspheres had a reasonable controlled release. This polymeric microspheres system can be further explored for the drug targeted delivery with maximum therapeutic efficacy and minimum adverse effects.