مظہر امام /پروفیسر شہریار/پروفیسر مغنی تبسم
افسوس اس ماہ فروری میں اردو کے آسماں پر درخشاں، چند ستاروں کے چھپ جانے سے اردو دنیا کی رونق میں کمی آگئی، جناب مظہر امام ، پروفیسر شہریار ، پروفیسر مغنی تبسم یکے بعد دیگرے رخصت ہوئے، مظہر امام کی شناخت آزاد غزل کے حوالے سے ہے، کئی شعری اور تنقیدی کتابوں کے مصنف تھے، پروفیسر شہریار اور پروفیسر مغنی تبسم، ہندوستان کی دو ممتاز جامعات یعنی مسلم یونیورسٹی اور جامعہ عثمانیہ میں اردو کے کامیاب اور نامور استاد ہی نہیں، شعرو ادب کی دنیا میں صاحب مرتبہ و مقام بھی تھے، شہریار کی شہرت گو ان کی زندگی کے دور آخر میں خوشبو کی طرح عام ہوئی لیکن نشاط غم اور رنج شادمانی کے مختصر اور فانی لمحات کا ساتھ عمر بھر رہا، ان کی شہرت کے شہپر جب سمٹے ہوئے تھے اس وقت بھی انہوں نے اس خاموشی کو بلیغ معانی دیے تھے، خواب، رات، دیار، پرچھائیں، سفر، تشنہ لبی کے پردے میں وہ دیار دل اور بزم دوستاں تلاش کرتے رہے، مغنی تبسم شہریار کے پیشہ تدریس میں ہی شریک نہیں رسالہ شعرو حکمت میں بھی برابر کے سہیم تھے، وہ حیدرآباد کے دائرہ ادبیات اردو اور رسالہ سب رس سے مدتوں وابستہ رہے، فانی بدایونی پر تحقیق کی تھی، درجنوں کتابیں لکھیں، عجیب بات ہے کہ ادبی سفر میں مغنی تبسم اور شہریار ساتھ ساتھ رہے، ابدی سفر میں بھی یہ رفاقت قائم رہی، شہریار کے نام ایک خط میں مغنی تبسم نے لکھا تھا کہ ’’شاعری تو ایسی چیز ہے جو خدا، انسان اور کائنات کے درمیان پچھلی راتوں کا دعائیہ بن جاتی ہے، کتنے لوگ ہیں جوان ساعتوں میں دست دعا دراز کرتے ہیں‘‘، مغفرت کے لیے کوئی عمل یا کوئی قول کام آسکتا ہے، ہمارا دست دعا بھی اسی لیے دراز ہے۔...
This research work investigated the interfaith harmony and social cohesion between two different religious followers of Hinduism and Islam in District Swat of Pakistan. The current world is facing various kinds of issues and challenges regarding interfaith harmony, peace and social cohesion. This is need of the time to establish a peaceful and harmonised day to day life standard for all the segments of society. This research was an effort to analyse the willingness among the Hindus and Muslims for enhancing their tolerance towards each other’s social and cultural activities. It also aimed to highlight the positive approach of the respondents towards the participation in the socio-cultural activities of each other. The results of association of social cohesion showed nonsignificant relationship with an opinion that Hindu and Muslim communities should take part in socio-cultural activities particularly the sports. Similarly, non-significant relationship was found based respondents’ data with an opinion that relations between Hindus and Muslims shall enhanced through participation in cultural and religious ceremonies. The result further concluded that there was peaceful and harmonised environment between Hindus and Muslims being living in the target area. The minorities were fully enjoying freedom and equality in District Swat. Based on the findings of the study, positive social interaction, mutual respect, positivity in thinking and positive role of local media have been recommended as policy guidelines for promoting inter-faith harmony.
Introduction: Colorectal cancer is the third most common cancer worldwide, as indicated by WHO. Local published and unpublished data indicate that patients in the developing world with colorectal cancer tend to present at an early age, and possibly at a more advanced stage than described in the developed world. The reason for this difference is unclear, and as yet undefined.
The Wnt/APC pathway, Microsatellite instability pathway and the Epigenetic pathway are three pathogenetically distinct pathways that have been implicated in the development of colorectal cancer. Exploration of these patterns may allow us to elucidate possible reasons for these differences.
Objectives: The aim of this study was to investigate the expression patterns of three molecules, β-catenin, p27 and COX-2, which represent various points of interaction along the Wnt/APC pathway, in colorectal cancers diagnosed at the Department of Pathology,Aga KhanUniversityHospital,Nairobi, and to correlate the findings with clinical, demographic and pathological characteristics of the study subjects.
Methods: Tissue blocks of 100 consecutive colorectal cancer resection specimens received during the period March 2006 to Dec 2009, were retrieved from the archives at the Department of Pathology. Haematoxylin and Eosin slides were prepared and reviewed for purposes of confirmation, typing, grading and staging of the colon cancer. Immunohistochemical expression for β-catenin, p27 and COX-2, was assessed and scored. Findings were correlated with relevant demographic, pathologic and clinical data.
Data Management and analysis: Data were recorded using a data sheet and then entered into an MS Excel spreadsheet. Statistical analysis was done using SPSS version 15.0 (SPSS Inc, Chicago) and STATA version 10.0 (Stata Inc,Texas).
Chi square test (or Fisher’s exact test when number was <5) was performed to determine the association between categorical variables.
Results:β-catenin aberrant expression was found in 75% of tumours. 93% of cases showed moderate to strong nuclear p27 expression and 78% of cases demonstrated moderate to strong COX-2 overexpression. β-catenin expression patterns were associated with tumour location, and COX-2 overexpression with tumour histological subtype.
Conclusion: The aberrant expression of β-catenin corresponds with the overexpression of COX-2, supporting their postulated relationship in the Chromosomal instability pathway.
The Wnt/APC pathway still appears to be the most common pathway, despite our younger population. The utility of p27 still requires further evaluation and validation, due to conflicting results.