الغرر في العقود, دراسة فقهية مقارنة بين المذاهب الأربعة

Islam is a way of life and it does not allow betray of any kind to anyone especially in trade and business. Islam does not allow to buy or sell any type of commodity by any means in which there is a chance of betray, and along with it Islam also does not allow jugglery, betting, selling of item before purchasing and selling a commodity without having a possession. In Islamic Jurisprudence these conditional trade is known asGhararIt is then divided in two types of which the first type is prohibited by all school of thoughts and the other type is allowed by some school of thoughts

Genetic Study of Susceptible Gene Involved in Kidney Stone Formation in Pakistani Families

In the gene vitamin D receptor (VDR) the polymorphisms have been reported by several studies to be linked with urolithiasis in various ethnic groups worldwide. This is preliminary report of investigating the role of VDR gene polymorphism in infantile urolithiasis in Punjabi population of Pakistan. In the present study, we examined the VDR gene polymorphism (TaqI) on PCR-RFLP based in seven families with positive family history of renal stone formation from Punjab province of Pakistan. The analysis showed that the single nucleotide polymorphism (SNP) followed HWE that p > 1.00. The allelic and genetic frequency varied significantly among patients and controls. Controls were with higher frequency of TT genotype whereas patients were with both CT and CC genotype. Genotype CT Taq-I and CC Taq-I demonstrated significantly higher risk (?2=57.778, df=2, ?2/df=28.89, P(?2 > 57.778) = 0.0000). Variant C allele of Taq-1 polymorphism exhibited higher risk (?2=60.379, df=1, ?2/df=60.38,P(?2 > 60.379) =0.0000). Therefore it was observed that Taq-I polymorphic site on VDR gene was significantly associated with the urolithiasis in studied patients (p< 0.01). Further, patients with combination of CC and CT of Taq-I increase the risk of renal stone. Overall, the present results suggested the Taq-1 VDR genotype could be candidate gene leading to infantile urolithiasis.