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Home > A Critical Study Of the Relationship Between Dietary Iiabits Verses Physiological and Bio- Chemical Changes in Essential Hypertensive Patients

A Critical Study Of the Relationship Between Dietary Iiabits Verses Physiological and Bio- Chemical Changes in Essential Hypertensive Patients

Thesis Info

Access Option

External Link

Author

Mahesar, Hidayatullah

Program

PhD

Institute

University of Sindh

City

Jamshoro

Province

Sindh

Country

Pakistan

Thesis Completing Year

2007

Thesis Completion Status

Completed

Subject

Philosophy and psychology

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/6316/1/4057H.pdf

Added

2021-02-17 19:49:13

Modified

2023-02-24 19:58:05

ARI ID

1676725281905

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کب سلیقہ ہے کہوں لفظ جو ہوں ان کی مثال

نعت
کب سلیقہ ہے کہوں لفظ جو ہوں اُنؐ کی مثال
اُنؐ کے ہی ذکر نے بخشے ہیں مجھے عمدہ خیال

اُنؐ کے ہی دامنِ دولت سے ملا ہے سب کو
اُنؐ کے ہونے سے زمانے ہوئے شاداں و نہال

اُنؐ کی سیرت سے ہے تہذیب کی تہذیب ہوئی
اُنؐ کی صورت سے جہاں بھر نے یہ پایا ہے جمال

منتظر مسجدِ اقصیٰ میں نبی تھے سارے
دیکھنے کے لیے سرکارؐ کی رحمت کا کمال

میں گدائے شہِؐ بطحا ہوں یہ قسمت میری
اُنؐ کی نسبت سے ہی پایا ہے فضا نے یہ کمال

الحياة الاقتصادية بمنطقتي الساقية الحمراء ووادي الذهب

تأتي الدراسة بهدف تقديم مقاربة علمية حول أبرز مظاهر الحياة الاقتصادية التي شهدتها منطقتي الساقية الحمراء ووادي الذهب الواقعة ضمن مجال الجنوب المغربي، حيث يتميز هذا المجال بغنى متنوع شمل مختلف المناشط الاقتصادية على الرغم من قساوة الظروف الطبيعية التي تعرفها دواخل صحراء جنوب المغرب، الأمر الذي حفزنا إلى البحث العلمي الدقيق حول بعض مظاهر هذه الثروات، مسلطين الضوء على موضوع الحياة الاقتصادية بمنطقتي الساقية الحمراء ووادي الذهب، وذلك سعيا منا لمواصلة خدمة البحث العلمي والأكاديمي حول هذا المجال.

Biochemical Analysis and Genetic Polymorphism of Angiogenic Factors and Inflammatory Markers in Pakistani Patients With Age-Related Macular Degeneration

Age related macular degeneration (AMD) is an ophthalmic disease with complex aetiologyand is considered to be one of the major reasons of blindness in aged population. Inflammatory processes are suggested to play an important role in AMD pathogenesis and its progression. The present cross sectional and case-control study was carried out to investigate the role of inflammatory markers and angiogenic growth factors in AMD pathogenesis. Diagnosis was done through slit lamp examination, OCT and FFA. Normotensive and non-diabetic subjects aged ≥50 years diagnosed with AMD were selected. Age matched healthy individuals with no symptoms of AMD were selected as controls. Serum lipids, apolipoprotein E (ApoE), leptin, HTRA1, interleukin 6 (IL-6), IL-8, vascular endothelial growth factor (VEGF), C-reactive protein (CRP) and complimentary factor H (CFH) were determined in patients and controls. Genotype analyses of single nucleotide polymorphisms (SNPs) in IL-6 gene (rs1800795; rs1800796; rs1800797); IL-8 gene (rs4073; rs2227306; rs2227543); VEGF gene (rs3025039; rs699947) and CRP gene (rs1205; rs1130864) were done through restriction fragment length polymorphism. Data were computed through SPSS version 18.0 (Chicago, Illinois, USA) and Graph Pad Prism (GraphPad Software, San Diego, California, USA). Data sets were compared between control and AMD patients through student’s t-test. Genotype and allele frequencies were compared through χ 2 . Significance level was p<0.05. Since the data were obtained from a sample population, to reduce heterogeneity of error, Box-Cox transformation algorithm was applied. Multivariate analysis of variance (M-ANOVA) was applied on the transformed data to investigate association of serum levels of IL-6, IL-8, VEGF and CRP with AMD. Transformed data showed elevated serum levels of IL-8 (p<0.015) and VEGF (p<0.0108) and reduced ApoE (p<0.032) in AMD patients compared to control subjects. Serum VEGF levels were significantly raised (p<0.0001) in wet AMD patients compared to the dry AMD patients. The IL-6 levels were significantly high in patients with genotype GG for rs4073(p<0.0001). IL-8 levels were significantly high in patients with genotype GG for rs2227543(p<0.002). Significantly high VEGF levels were observed in patients xwith genotype TT for rs3025039(p<0.038). CRP levels did not change significantly with respect to genotype forrs1205 and rs1130864. The study concludes that inflammatory markers and angiogenic growth factors are significantly altered in AMD pathogenesis. Significant findings of the present study which are pertinent to mention is that altered levels of inflammatory markers and angiogenic factors are related to the genetic polymorphism for IL-6, IL-8 and VEGF genes. However, SNPs in relation to CRP were not related to serum CRP levelsin AMD patients.