مولانا معین الدین اجمیرؔی
۱۰؍ محرم الحرام ۱ ۱۳۵۹ھ عین عاشورہ کے دن علم و عمل فضل و کمال، مجاہدہ و استقامت وطہارت کی ایک ایسی مسند خالی ہوئی جو غالباً عرصۂ دراز تک خالی رہے گی، اِنَّا لِلّٰہِ وَاِنَّا اِلَیْہِ رَاجِعُوْنَ۔
اس سے ہماری مراد حضرت مولانا معین الدین اجمیری رحمۃ اﷲ علیہ کا سانحۂ ارتحال ہے، یہ حادثہ محض مولانا کے اہل خاندان یا مسلمانانِ اجمیر ہی کے لئے نہیں ہے، بلکہ سارا اسلامی ہند اس سے متاثر اور اپنی کم نصیبی پر نوحہ کناں ہے۔
وَمَا کَانَ قَیْس’‘ ھَلَکَ ھُلَکَ وَاحِدٍ
وَلٰکِنَّہٗ بُنْیَان قُوْمٍ تھَدّما
مولانا ایک نومسلم گھرانے میں پیدا ہوئے تھے، والد ماجد مولانا عبدالرحمن صاحب مرحوم بلیاؔ کے رہنے والے نومسلم راجپوت تھے اور والدہ بھی داخل اسلام ہوئی تھیں اور دانا پور (بہار) ان کا گھر تھا تعلق راجپوتانہ سے اس طرح پیدا ہوا کہ مولانا عبدالرحمن صاحب ریاست ٹونک میں سیکریٹری کونسل تھے، چار یا پانچ سو روپیہ ماہوار تنخواہ تھی، اسی علاقہ میں دیولی (راجپوتانہ) میں ۲۵؍ صفر ۱۲۹۹ء کو پیدا ہوئے اور باپ کے زیر سایہ زندگی کی ابتدائی منزلیں طے ہوئیں، بچپن ہی سے سعادت و فیروز مندی کے آثار نمایاں تھے، چنانچہ دولت و ثروت کی گود میں پلنے والے اس نوجوان نے ہمیشہ طالبعلموں میں مساوات ہی کی زندگی بسر کی، امیرانہ ٹھاٹھ اور رئیسانہ شان کا کبھی مظاہرہ نہ کیا۔
قسمت کی خوبی اور نصیب کی بلندی نے خاتم المحققین حضرت مولانا سید برکاتؔ احمد صاحب (بہاری، ثم) ٹونکی سے تلمذ کا رشتہ قائم کرایا، اس تعلق سے مولانا کا سلسلۂ تلمذ یہ ہے۔
حضرت مولانا معین الدین صاحب اجمیری رحمۃ اﷲ علیہ
حضرت مولانا سیّد برکات احمد صاحب ٹونکی رحمۃ اﷲ علیہ
حضرت مولانا عبدالحق صاحب خیرآبادی رحمۃ اﷲ علیہ
حضرت مولانا فضل حق صاحب خیرآبادی رحمۃ اﷲ علیہ
حضرت مولانا...
Islam is the only religion which is complete code of life. The needs of human beings have been felt and addressed properly. In spite of created by only one creator humans are different in their potentials, behavior and attitude. Owing to this difference, the incomes of people are drastically different from each other. As a result, a few people are rich and well off whereas some are poor- being up to sustenance level. Therefore, people cooperate with each other to eliminate the class differences of social strata. In this perspective, Islam has given an invulnerable perfect socio-economic system. For mutual cooperation, Islam has also addressed the issue and suggested different steps such as madharabah, partnership and tenancy. Bedsides Islam has also focused on secondary resources of mutual cooperation and support that are typically related to the personal concern. It includes: sacrifice, gift, free lending and Qarz-e- Hasanah etc. It also reflects that the man gives precedence to congregational matters over his individuality which is an ample example of mutual cooperation. In fact, mutual cooperation is one of those key factors on which the edifice of prosperous society is built. All religions and ideologies have focused and emphasized on the mutual cooperation; however, Islam lays extra emphasis to build a strong and thriving human state.
Present research work was planned for the formulation of cardioprotective nanosuspensions of four indigenous medicinal plants with improved bioavailability and better therapeutic efficacy. Ongoing research was divided into four different phases. First phase of the study was comprised of formulation and optimization of formulative parameters for the preparation of stable nanosuspensions by using CCD design of RSM. Characterization (ZP, SEM, AFM and FTIR) and stability studies of optimized nanosuspensions was the second phase of the study. In third phase of study, in-vitro dissolution testing and in-vivo pharmacokinetic profile of selected nanoformulations was determined. In fourth phase, different in-vitro and in-vivo bioactivities and toxicity studies of optimized nanosuspensions were evaluated with reference to the respective coarse plant suspensions. Results of stabilizer screening demonstrated that SLS was the best stabilizer for the formulation of A. cepa and C. oxyacantha nanosuspensions. HPMC was the selected stabilizer for P. nigrum and P-80 was chosen for the formulation of T. arjuna nanosuspensions. Among the optimized nanosuspensions, minimum particle size with appropriate PDI value was possessed by T. arjuna (79.1nm, 0.244) followed by C. oxyacantha (121.3nm, 0.241), P. nigrum (172.9nm, 0.328) and A. cepa (275.5nm, 0.415) nanosuspension. Results of zeta potential studies confirmed the stability of the optimized nanosuspensions. Results of AFM and SEM illustrated that nanosuspensions were in nanometer range with varied particle size and morphology. FT-IR studies indicated slight interaction between herbal extracts and stabilizers. Moreover, optimized nanosuspensions of all the four medicinal plants showed better stability at refrigerated conditions. Dissolution and pharmacokinetic studies demonstrated improved results for nanosuspensions as compared to coarse suspensions of the respective plant extracts. In-vitro (antioxidant, antimicrobial, hemolytic, thrombolytic) and in-vivo (cardioprotective) bioactivities also revealed better therapeutic efficacy of nanosuspensions over coarse suspensions. Results of toxicity studies confirmed the non-toxic nature of formulated nanosuspensions. From the present results it was concluded that nanosuspensions of the selected herbal extracts can be used as a better alternative to treat cardiovascular diseases with improved therapeutic efficacy as compared to their conventional coarse suspensions.