ڈاکٹر سید عبدالعلی
افسوس ہے کہ آج قلم کو ایک ایسی برگزیدہ شخصیت کا ماتم کرنا پڑرہا ہے جو تنہا ایک شخص کا نہیں بلکہ علم و عمل کا ماتم ہے، دین و تقویٰ کا ماتم ہے، اخلاق و شرافت کا ماتم ہے، اس شخصیت کو دنیا ڈاکٹر سید عبدالعلی ناظمِ ندوۃ العلماء کے نام سے جانتی ہے، وہ تنہا ڈاکٹر یا ندوۃ العلماء کے ناظم نہ تھے، بلکہ اس زمانہ میں اپنے اوصاف، خصوصیات اور دینی و اخلاقی کمالات میں یگانہ تھے، ان کا نسبی تعلق مشہور عارف باﷲ حضرت سید شاہ علم اﷲ رحمتہ اﷲ علیہ رائے بریلوی کے خاندان سے تھا جس میں علم و عمل، دین و تقویٰ، فقر و تصوف اور ارشاد و ہدایت کی روایات صدیوں سے چلی آرہی تھیں، حضرت سید احمد شہید رحمتہ اﷲ علیہ اسی دووانِ عالی کے گوہر شب چراغ تھے۔
خاندان کی یہ ساری روایات ڈاکٹر صاحب مرحوم کے حصہ میں آئی تھیں، ان کے والد بزرگوار مولانا حکیم سید عبدالحئی صاحب رحمتہ اﷲ علیہ اپنے زمانہ کے مشہور عالم، نامور طبیب، اہل قلم فاضل اور صاحب زہد و تقویٰ بزرگ تھے، ڈاکٹر عبدالعلی صاحب ان کے خلف الصدق تھے، ان کی ذات قدیم و جدید تعلیم کا سنگم تھی، انہوں نے پہلے عربی اور طب کی تحصیل کی، اس کے بعد انگریزی پڑھی اور ڈاکٹری کی تعلیم حاصل کی، یہ وہ زمانہ تھا جب ڈاکٹروں کی زندگی مغرب زدگی اور انگریزی طرز معاشرت کا نمونہ ہوتی تھی، مگر ڈاکٹر عبدالعلی صاحب کی فطرت ایسی صالح و سلیم تھی اور ان کی رگوں میں ایسے بزرگوں کا خون تھا کہ جدید تعلیم کے مادی اثرات سے ان کا دامن بالکل پاک رہا، حتیٰ کہ ان کی ظاہری وضع قطع بھی خالص اسلامی رہی ناواقف لوگ ان کو دیکھ کر گمان نہیں کرسکتے تھے کہ ان کو...
Establishment of khilafah and tamkeen fil ‘ard means supremacy of the dictates of shari‘ah and socio-political justice on earth. This is one of the basic objectives and prominent messages of the Holy Quran and Seerah of Prophet Muhammad (s.a.w). About khilafah and tamkeen fil ‘ard the Holy Quran expresses as: -وَعَدَ اللَّهُ الَّذِينَ آمَنُوا مِنكُمْ وَعَمِلُوا الصَّالِحَاتِ لَيَسْتَخْلِفَنَّهُم فِي الأَرْضِ … -الَّذِينَ إِن مَّكَّنَّاهُمْ فِي الأَرْضِ أَقَامُوا الصَّلاَةَ وَآتَوُا الزَّكَاةَ وَأَمَرُوا بِالمَعْرُوفِ وَنَهَوْا عَنِ المُنكَرِ وَلِلَّهِ عَاقِبَةُ الأُمُورِ. -هُوَ الَّذِي أَرْسَلَ رَسُولَهُ بِالْهُدَى وَدِينِ الْحَقِّ لِيُظْهِرَهُ عَلَى الدِّينِ كُلِّهِ وَكَفَى بِاللَّهِ شَهِيداً. Prophet Muhammad (s.a.w) proclaims: - وَاَللَّهِ لَوْ وَضَعُوا الشَّمْسَ فِي يَمِينِي وَالْقَمَرَ فِي يَسَارِي عَلَى أَنْ أَتْرُكَ هَذَا الْأَمْرَ حَتَّى يُظْهِرَهُ اللَّهُ أَوْ أَهْلِكَ فِيهِ مَا تَرَكْتُهُ. The Holy Quran and the Seerah refer to some underlying milestones on the way of religious nations to status of khalafah and tamkeen fin ‘ard. These milestones may be expressed in an order as: da‘wah [preaching], deen [practices of prophetic teachings], hijrah [migration], ma‘iyyat-ul-Allah [companionship of Allah], qital [wars], nusrat-ul-Allah [divine aid], izhar-ud-deen [domination of deen] and khilafah [inheritance of authority]. This is noteworthy that journey of khalafah and tamkeen fin ‘ard begins with da‘wah [preaching towards deen] and passing through various milestones ends up again at da‘wah, as obvious from ayat-ul-istakhlaf quoted above. Therefore, the seekers of khilafah and tamkeen fil ‘ard should strive hard and keep struggling with the work of da‘wah with dedication in all circumstances and all means as per time and place requirements in lined with the modus operandi of Prophets, particularly Prophet Muhammad (s.a.w), instead of awaiting the status of khilafah and tamkeen fil ‘ard as prerequisite to start with the work of da‘wah and establishment of deen. This paper primarily aims to elaborate the milestones of Muslim Ummah to reach to the status of khilafah and tamkeen fil ‘ard. It also cast light on the objectives of khilafah and tamkeen fil ‘ard. This work provides useful guidance to Muslim Ummah in general and Ahlud da‘wah in particular about milestones and objectives of khilafah and tamkeen fil ‘ard.
Formulation Development and in-vivo Performance of Pharmaceutical Cocrystals The use of soluble cocrystal for delivering drugs with low solubility, although a potentially effective approach, often suffer from the problem of rapid disproportionation during dissolution, which negates the solubility advantages offered by the cocrystal. This necessitates their robust stabilization in order for successful use in a tablet dosage form. The cocrystal between carbamezepine and succinic acid (CBZ-SUC) exhibits a higher aqueous solubility than its dihydrate, which is the stable form in water. Using this model system, I demonstrate an efficient and material-sparing tablet formulation screening approach enabled by intrinsic dissolution rate measurements. Three tablet formulations capable of stabilizing the cocrystals both under accelerated condition of 40oC and 75% RH and during dissolution were developed using three different polymers, Soluplus® (F1), Kollidon VA/64 (F2) and Hydroxypropyl methyl cellulose Acetate sucinate (F3). When compared to a marketed product, Epitol® 200 mg tablets (F0), drug release after 60 min from formulations F1 (~82%), F2 (~95%) and F3 (~95%) was all higher than that from Epitol® (79%) in a modified simulated intestinal fluid. Studies in albino rabbits showed correspondingly better bioavailability of F1 – F3 than Epitol® tablets. All the three experimental formulations gave statistically significant improvements in AUC0-72 of CBZ than Epitol tablets by applying ANOVA followed by Tukey’s post hoc test (*P˂0.05 for F0-F1, ***P˂0.05 F0-F2, ***P˂0.05 F0-F3). Among the three formulations, F2 tablet formation was the best based on both in-vitro and in-vivo evaluations. Towards the second formulation approach, I first used common polymers to study the supersaturation of carbamezepine-succinic acid (CBZ-SUC) cocrystal at different conditions. In-situ Raman spectroscopy was used to monitor the solid phase during dissolution studies. The solid phase at the end of each experiment was characterized by FTIR and powder X-Ray diffractometry. In-vivo study was performed on selected xi suspension formulations. In absence of polymers, no dissolution advantage was attained by cocrystals due to rapid crystallization of CBZ dihydrate. At room temperature Polyvinyl pyrrolidone (PVP) at concentration of 2% w/v did not stabilize the supersaturated solution, whereas polymer concentration of 0.025% w/v hydroxypropyl methyl cellulose acetate succinate (HPMCAS) stabilized the cocrystal and enhanced the solubility of CBZ in buffer solution at pH 6.8 by 3.2folds to that of stable dihydrate form. A formulation of CBZ-SUC cocrystal containing HPMCAS as a crystallization inhibitor and soluplus® as solubilizer, superior in-vitro dissolution performance was achieved compare to pure CBZ having similar composition at 37±1Ċ. Pharmacokinetic studies in rabbits showed that one of the formulations F7-X (1% w/v cocrystal, 1% w/v HPMCAS and 2% w/v soluplus®), caused around 6folds enhancement in AUC0-72 (***P˂ 0.05), and also led to a much higher Cmax of 4.73 μg/mL than 1.07 μg/mL Cmax of ‘neat’ cocrystal given orally. Also, the F7-X outperformed a reference formulation of CBZ by {1.37folds AUC0-72 of cocrystal formulation (***P˂ 0.05) and Cmax of 3.9 μg/mL} with similar composition to F7-X.