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Home > A Histological Study of Human Olfactory Mucosa: Regional Distribution and Age Related Changes

A Histological Study of Human Olfactory Mucosa: Regional Distribution and Age Related Changes

Thesis Info

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Author

Jafari, Fahim Haider

Program

PhD

Institute

University of Health Sciences

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2006

Thesis Completion Status

Completed

Subject

Natural Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/492

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725398777

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The present study on the morphology of human olfactory mucosa was carried out with emphasis on its regional distribution, and changes related with age and gender. Eighty tissue samples (forty for either sex) were collected from cadavers ranging from 30 to 82 years of age, available in the mortuary of King Edward Medical College, Lahore. Individual age groups of males and females included 10 specimens from each sex. The histological study of the mucosa included morphology, regional distribution, quantitative analysis of all four major types of epithelial cells, height of epithelium and thickness of lamina propria in the roof, medial and lateral walls of both nasal cavities. A detailed study of the epithelium revealed the presence of classically known three cells: olfactory cells, sustentacular cells and basal cells and a fourth type, microvillar cells. In the age group 30-39 years (male and female) the mucosa was seen in the roof lying next to cribriform plate of the ethmoid bone and extending on both sides of the nasal septum and on the lateral walls of both nasal cavities. At places the respiratory epithelium was seen in the area of the olfactory epithelium which was much thicker. In the age group of 40-49 years, early age related changes were observed in the shape of occasional short epithelial invaginations, and disturbance of the zonal distribution of olfactory and supporting cells. In the age group 50-59 years, major morphological changes were observed like substantial reduction in the number of nuclei resulting in decreased height of the epithelium, disturbance of zonal distribution and presence of epithelial invaginations. The age group of 60 years onwards showed gradual thinning of the epithelium, epithelial invaginations, and in few cases atrophied olfactory epithelium devoid of olfactory cells. ANOVA showed significant age related decrease in the number of olfactory and sustentacular cells and in the height of the olfactory epithelium among the male and female groups. There was no significant age related decrease in the number of basal cells and thickness of the lamina propria. The number of microvillar cells was markedly less when compared to other cells of the epithelium. These results suggest that loss of olfactory and sustentacular cells becomes pronounced in individuals of both sexes of 50+ years of age. The results of the present study suggest that the reduction in the number of olfactory receptors and in the height of neuroepithelium with advancing age is associated iiwith impairment of olfactory sensibility. There was no evidence of significant sex related differences in the olfactory mucosa. These results are in the accordance with the previous observations in humans and other mammals showing a decline in the olfactory capacity with aging, mostly attributable to a decline in the number of olfactory cells. Contrary to earlier observations, the present study did not reveal any conclusive evidence that females had an increased sense of smell based on histological observations alone.
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PRIORITIZING FALL RISK MANAGEMENT: IRRESPECTIVE OF PARKINSON’S DISEASE PROGRESSION DURING REHABILITATION

Background and Aims: It has been established that the hazard of falling in Parkinson's patients is a primary cause of loss of independence, and hence it is a significant component to the disease's burden. As a result, the goal of this study is to evaluate the relationship between level of disease progression and the risk of falling in order to understand the critical need for rehab intervention in Parkinson's disease. Methodology: A cross-sectional survey was conducted on 24 participants participated in study through convenience sampling technique from primary and tertiary care institutes/ hospitals. Tinetti balance and gait test was used to evaluate the risk of fall among patients while The Hoehn and Yahr Scale was used to track the progression of Parkinson's symptoms and disability. Results: Total 24 (n=24) participants with idiopathic Parkinson’s disease were enrolled in the study in which the majority of the participants belong to age group 59-69 years. The balance and gait of Parkinson’s patient is strongly negative correlated i.e. -8.33 with the severity of Parkinson’s disease with .000 level of significance which is strongly negative correlated with the severity of Parkinson’s disease (p<0.05). Conclusion: This demonstrates that the balance and gait of a Parkinson’s person is not related to the severity level Parkinson’s disease thus fall management in PD patients must be kept in priority during the rehab intervention for ADL independence and social participation.

Factors Associated With Male Youth Involvement in Violence in the Punjab, Pakistan

Youth violence and crimes in developing countries have been increased in general but in Pakistan and particularly in the Punjab, it is noticed more increasing more rapidly. The more recent increase in crime rates in developing countries has awakened a widespread concern about personal safety and property insecurity. Statistically every year, more than a million people lose their lives in violence and crimes. Violence is resultant from a variety of situations in young people’s lives as well as the experiences of childhood that can lead towards the serious consequences when they reach to adolescence which is called a stage of rapid development, uncertainty, experimentation and adventure. The increase of violence and particularly, the increasing involvement of youth in social and economic violence irrespective of them being victims or perpetrators have become a naked reality and a burden upon human, social, ethical and economic spheres (Moser, 2002). According to Pakistan’s population census of 1998, there were 34.3 million young people (male and female) between the ages of 15 to 29 years. According to the projections made by US Census Bureau, population of Pakistan in 2010 estimated to be 177,276,594 and the youth falling between the age of 15-29 years (53,265,671) contributes to 30.1% of the total projected population. Whereas the total number of male youth population (15-29) in 2010 was 267,800,000 that made 15.12% of the total population. A cross sectional survey was conducted, in three central jails (Faisalabad, Mianwali, Multan) selected randomly from the total 9 central jails in the Punjab. A sample of 400 convicted prisoners from the total of 1400 convicted prisoners 15-29 years {using the table for estimating sample size constructed by the Krejcie and Morgan (1970)} was selected randomly using the lists of prisoners arranged by the DIG Prisons. A sample of 250 family members/relatives/others was also selected conveniently at the time of their visit to the jail to assess the problems faced by them after the incident. A well designed questionnaire consisting of questions of both types open and close ended prepared in the light of the research objectives. Pre-testing of the questionnaire was also made to check the workability of the questionnaire and avoid the sensitive issues. Descriptive statistics such as frequency distributions, mean, standard deviation, coefficient of variation was used to generalize the data. Bivariate analysis such as Chi-square and Gamma tests were also used. Multivariate analysis such as correlation and regression were also applied for model building in order to assess male youth involvement in violence in the Punjab-Pakistan. The results indicate that 49.5% respondents belonged to the adolescent age cohort (15-19 years), 32.5% belonged to youth age cohort 20-24 and 18% belonged to young adult age cohort (25-29 years) with a mean age of 23.84. The research findings revealed that (29.75%) respondents were illiterate, and the remaining 70% found literate. From literate respondents (16.25%) got education up to primary level, 26.25% from sixth class to middle, 27.75% from 9 th class to above with a mean education of 5.73 years. According to the findings of the study 73.2% respondents belonged to rural areas and the remaining 26.8% belonged to urban areas. About fifty percent (49.5%) families were consisting of 7 or more than 7 members, 40.75% families 5-6 and the remaining 9.75% having 3-4 family members with a mean family size 9.51 members. About 15% respondents were student at the time of arrest, 7.5% had noting, 10.75% doing farming with their parents , 18.5% busy in business , 4.25% doing Govt. Job, 5.75% busy in private job and 38.25% were laborer at the time of their arrest. 23.5% respondents used drugs, and from them 45.46% respondents committed sex/rap after using drugs, 31.82% quarreling with people and 15.91% goes for robbery after taking drugs. The research findings revealed that 50.8% respondents committed first crime when they were 16-20 years old, and the majority (76.75%) of respondents committed murder at their first crime. About 44.8% respondents committed crime alone and 27, 25.8 and 2.5% respondents committed crime in the company of their friends, relatives and friends and other persons, respectively. There are several reasons/causes of committing crimes by youth. The main cause of committing crime was taking revenge 22.25%, followed by poverty 17.25% and peer pressure 10.25%. The other causes reported by the respondents were money conflict 9%, motivation of the media 8.25%, accidental/misunderstanding 7.5%, drug addiction 6.75%, sexual lust 6.25%, family disruption 6% and self pleasure/fun 3.75%. A substantial percentage 49.8% of the respondents was convicted more than 31 years, followed by 36.5% of the respondents who were given death sentence for their crimes, the next category of the respondents reported 21-30 years conviction for their crimes and their percentage was 37.3. The percentages of the respondents were 3.0, 4.0, 5.0 and 1.0 who reported up to 4 years, 5-9 years, 10-14 years and 15-20 years for conviction of crimes. The multivariate result shows that the index variable age has the highest negative value which is -0.221 highly significant at 1% level of significance indicating that the index variable age is the most important predictive variable in effecting the violent behavior of youth. The other significant variables are education having beta coefficient -0.102, father education -0.099, family size 0.097, father income - 0.138, self control -0.066, self esteem -0.121, family practices -0.195, community factors -0.128, educational attainment -0.153, gang/group membership 0.153 are significantly associated with violent xivbehavior of youth in effecting the male youth involvement in violence. The highest value of Pearson’s correlation coefficient all of variables age, education, education of the respondents father, education of the respondents mother, family size, economically active involvement, father income, self control, self esteem, Life satisfaction, family management, family practices, parents monitoring, community factors, educational factors and gang/group membership indicating that these variables are highly correlated with violent behavior of youth. The most important recommendation of the research is to educate the parents to promote positive climate at their homes and they should encouraged values such as respect, trust and cooperation. Also parents should monitor their children, where they are, who their friends are, when they are coming in and out.