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Advancements in Interstitial Brachytherapy

Thesis Info

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Author

Shahid Bashir Awan

Program

PhD

Institute

University of the Punjab

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Physics

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/2204

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725439377

Similar


In recent years, interstitial brachytherapy implantation has become the treatment of choice for early stage prostate cancer patients. The popularity of this modality is due to the fact that five-and ten-year disease control rates using brachytherapy are equal to those of surgery, whereas, the toxicity and side-effects are perceived to be lower. Recently, a true linear source model RadioCoilTM103Pd has been introduced to overcome the shortcomings of traditional ―seed‖ type interstitial prostate brachytherapy implants, such as migration and clumping of the seeds. However, the existing prostate treatment planning systems and TG-43U1 have not been updated to perform dose calculation and parameterization respectively, for implant with linear sources greater than 1.0cm in length. Due to these limitations, the innovative design of RadioCoilTM103Pd could not be fully implemented for clinical applications. In this research, treatment planning aspect of elongated RadioCoilTM103Pd sources is investigated. In addition, accuracy of existing TG-43U1 recommended dosimetric parameters in polar coordinate systems, a modification in radial increment to improve the accuracy and modification of TG-43U1 parameterization in to cylindrical coordinate systems is also investigated. This work resulted in a calculational method and modification in TG-43U1 parameters for accurate dose calculation around elongated sources. Experimental, Thermolumenance Dosimetry TLD and Monte Carlo simulation techniques were employed in this investigation. This work was successfully completed and led to a new Task Group, TG-143 from American Association of Medical Phyicists in Medicine, AAPM, to provide guidelines for clinical application of elongated sources and extend our findings for other elongated sources.
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دل شاہ جہاں پوری

حضرت دلؔ شاہ جہاں پوری
حضرت دلؔشاہ جہاں پوری بڑے پایہ کے قدیم اساتذۂ شعرو سخن میں سے تھے۔فنی اعتبار سے وہ مسلمہ طورپرجانشینِ امیر مینائی تھے۔نظام حیدرآباد نے بھی ازراہِ قدردانی اُن کو اعتبار الملک کاخطاب دیا تھا۔اُن کی شاعری کااصل میدان تغزل تھا، اگرچہ قدرت ہرصنف پررکھتے تھے۔’’نغمۂ دل‘‘اور’’ترانۂ دل‘‘ کے نام سے اُن کے دومجموعے شائع ہوکر عوام وخواص میں مقبول ہوچکے تھے۔ اُن کے تلامذہ کی تعداد جن میں اب بعض خود استاد ہیں سینکڑوں تک پہنچی ہوگی۔ شعروسخن کے علاوہ موصوف اونچے درجے کے طبیب اوردرس نظامی کے باقاعدہ فارغ التحصیل تھے۔اخلاقی اعتبار سے بھی بڑے بلند مرتبہ بزرگ تھے۔ نہایت بامروت وسیر چشم،متواضع،خوددار اورغیور۔ افسوس ہے پچھلے دنوں نوے برس کی عمر میں وفات پائی۔اب ایسے لوگ کہاں ملیں گے؟ اﷲ تعالیٰ مغفرت و رحمت کے لطف ونوازش سے سرفراز فرمائے۔آمین [مارچ۱۹۶۰ء]

The Local Government System of Pakistan: Participation, Representation and Empowerment of Women

Politics is the field where women have been ignored since ancient times, due to the political notions determined by ideological beliefs and cultural norms. Among the United Nations’ measures remove gender inequalities, includes recommendation for reserving 30 per cent seats for women in legislatures. In Pakistan, this remarkable change was effected in 2000, as it reserved 33 percent seats for women at the local government and 17 per cent at the Provincial/National Assemblies and the Senate level, so about 40,000 women entered in local bodies throughout the country in 2000-01, and almost 55,000 women contested local government in 2005. Despite these developments, women are still facing challenges that deter the full realization of their roles as active interlocutors of policy-making. Keeping in view these aspects, this paper has analyzed the local government, focusing on women, exploring whether the increasing number of women in legislatures is merely a numerical strength, or is empowering them, too, Whether they are the ‘subjects of change’ or the ‘agents of change.’ It is calculated that administrative structures of local government is male-dominated, whereas women are trying to ensure their position, however, gendered barriers remain unbroken

Study of Cure Kinetics, Chemorheological and Thermal Behaviour of Different Formulations of Dgeba Epoxy

Advanced composite industry use various methods to fabricate the composite components. The selection of fabricating method is a matter of required specific design of composite, cost effectiveness, manufacturing challenges, high volume production of the material and application. Various resin infusion techniques are being employed to meet the production challenges. Rapid resin transfer molding (RTM) is one of the vacuum assisted method for resin infusion. The resin required by RTM (Resin Transfer Molding) must have very low viscosity for fast injection into the mold cavity and into the reinforcement fabric at room temperature. Resin should also show high cure rate/short gel time when heated in the mold at its cure temperature. In this research work various formulations were developed based on DGEBA epoxy for rapid RTM (Resin Transfer Molding) process. The aim was to develop the resin formulations with low viscosity and long gel time at room temperature for quick mold filling, and very fast curing once the resin is heated inside the mold at its curing temperature. A commercially available DGEBA based epoxy resin (D.E.R.™ 331™) was used as base resin. Triethylene-tetraamine (TETA) (D.E.H.™24) an aliphatic polyamine was employed as curing agent. The viscosity of resin was varied by adding an epoxy based reactive diluent whereas the resin cure rate was enhanced by adding imidazole in the formulations. The formulations were developed by varying the mole ratios of epoxy, amine, diluent and imidazole. Several epoxy resin formulations were studied and compared with the commercially available infusion-grade epoxy system of Araldite LY 8601/Aradur 8602. DSC was employed to monitor the in-situ cure reaction by using isothermal and non-isothermal modes of measurements. Activation energy of cure reaction for each formulation was calculated using the Kissinger and the Ozawa equations. Model free analysis was used to evaluate dependence of activation energy on degree of cure. Addition of imidazole effectively reduces the activation energy of cure reaction of base epoxy from 57.5 kJ/mol to 46.5 kJ/mol. The diluent was added to lower the viscosity of resin and to enhance the resin flow behavior but it slows down the rate of reaction which is compensated by addition of 5% imidazole. Rate of cure reaction was increased as the temperature was increased which is depicted by degree of cure and glass transition temperature increase. At higher degree of cure, Tg values were utilized to vi evaluate the degree of cross linking at higher temperatures of cure. A relation between Tg and degree of cure was developed. Epoxy and amine with 10% diluent and 5% imidazole (DD/5I/10E) formulation was capable of getting maximum cured within 5 minutes at 100 ℃. Chemorheological studies were carried out to monitor the resin flow behavior. Viscosity at room temperature was measured and a time-viscosity relation was developed at various temperatures to measure viscous flow activation energy. Lowest viscosity was observed for commercially available infusion-grade epoxy system of Araldite LY 8601/Aradur 8602 at any temperature, whereas epoxy and amine with 10% diluent and 5% imidazole (DD/5I/10E) formulation showed the lowest viscosity of 1.04 Pa.s at 1 s-1 shear rate at room temperature. Fastest gelation (26s) was achieved by pure epoxy and amine formulation (DD). Thermal stability of developed formulations were calculated by TGA. All the developed formulations were found to be thermally quite stable more than 300 °C it was observed that addition of imidazole makes base resin thermally more stable. Maximum thermal stability was shown by formulation with 5% imidazole i.e. 380 °C. TGA thermograms were recorded at various heating rates and the activation energies of degradation were determined for all the formulations using Kissinger’s equation. Viscoelastic behavior of maximum cured formulations was also studied by DMA. Among all the values obtained for storage moduli (E′) the lowest values was found to be 1109 MPa associated with epoxy and amine with 10% diluent and 5% imidazole (DD/5I/10E) formulation. Among all the values of loss moduli (E″) for all the formulations the highest value, 212 MPa, was also observed for epoxy and amine with 10% diluent and 5% imidazole (DD/5I/10E) formulation. The results show that epoxy systems such as that containing 5% imidazole and 10% reactive diluent are suitable for the rapid RTM (Resin Transfer Molding) process with balanced flow and cure characteristics.