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An Approach for Artificial Pancreas to Control the Type-I Diabetes Mellitus

Thesis Info

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Author

Farman, Muhammad

Program

PhD

Institute

The University of Lahore

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Mathemaics

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10601/1/Muhammad%20Farman%20%28DMAT01143004%29%20PhD%20Thesis.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725466377

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Currently diabetes mellitus is worldwide issue and challenges for diabetes community for healthy life. An effort is made to develop the idea of getting a fully automated artificial pancreas. The artificial pancreas is a developing technology to help patients with diabetes of type 1 diabetes mellitus (T1DM) to control automatically their blood glucose level by making available the alternative endocrine functionality of a healthy pancreas. The concept of controllability and observability for the linearized control system of human glucose insulin system is used so that we can have a feedback control for artificial pancreas. For the purpose of automatic artificial pancreas in the glucose regulatory system, we consider the Glucose Insulin (GI) Systems and Glucose Insulin Glucagon (GIG) systems. These models includes Augmented Meal Model (AMM), Reduced Meal Model (RMM), fractional order glucose insulin system, a composite model of Glucagon-Glucose Dynamics Model and Sorenson model being comprehensive model for Type-1 Diabetes Mellitus (T1DM). These models can be used to simulate a glucose insulin system for the treatment of T1DM. The Lyapunov Equation is used to check the stability analysis of the model. A fractional-order time derivatives model is presented for comprehensive glucose insulin regulatory model. A fractional-order state observer is designed for approximating the structure of a blood glucose-insulin with glucose rate disorder to show the complete dynamics of the glucose-insulin system with the fractional-order at α ∈ (0 < a < 1]. The developed method provides the observer estimation algorithm for a glucose-insulin system with unknown time-varying glucose rate disturbance. Numerical simulations are carried out to demonstrate our proposed results and show the nonlinear fractional-order glucose-insulin systems are at least stable as their integer-order counterpart in the existence of exogenous glucose infusion or meal disturbance. Controllability and observability of the linearized model are calculated under two different cases,for case 1 insulin is taken as an input and case 2, insulin and glucagon are taken as an input for the system. This played an important role in the development of fully automatic artificial pancreas by stabilizing the control loop system for the glucose-insulin glucagon pump. Proportional Integral Derivative (PID) controller is designed for an artificial pancreas by using the transfer function. According to the desire value, the algorithm of an artificial pancreas measures the glucose level in the blood of a patient by using glucose sensor that sends a signal to an insulin glucagon pump to adjust the basal insulin. A closed-loop system is tested in simulink environment and simulation results show the performance of the designed controller. We convert the Sorenson model to Sorenson model type 1 diabetes mellitus because this is the most comprehensive model in the Glucose Insulin Glucagon dynamics for human. This may play an important role in the development of fully automatic artificial pancreas and stabilize the control loop system for the Glucose Insulin Glucagon pump. It would be helpful for type 1 diabetic patients to control their diseases. The thesis is also review the state of art in hypoglycemia prevention and detection technique in the closed-loop artificial pancreas. Hypoglycemia is the major adverse effect of insulin therapy and therefore minimizing the risk of hypoglycemia, by applying different control and detection techniques is often considered in the development of artificial pancreas.
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اشفاق احمد

اشفاق احمدرجحان ساز شخصیت
پیدائش:
معروف دانشور، ادیب، ڈرامہ نگار، تجزیہ نگار، سفر نامہ نگار اور براڈ کاسٹر جناب اشفاق احمد خان بھارت کے شہر ہوشیار پور کے ایک چھوٹے سے گاؤں خان پور میں ڈاکٹر محمد خان کے گھر 22 اگست 1925ء کو بروز پیر پیدا ہوئے۔
تعلیم:
اشفاق احمد کی پیدائش کے بعد اْن کے والد ڈاکٹر محمد خان کا تبادلہ خان پور سے فیروز پور ہو گیا۔ اشفاق احمد نے اپنی تعلیمی زندگی کا آغاز اسی گاؤں فیروز پورسے کیا۔ اور فیروز پور کے ایک قصبہ مکستر سے میٹرک کا امتحان پاس کیا۔اشفاق احمد نے ایف۔ اے کا امتحان بھی اسی قصبہ فیروز پور کے ایک کالج ‘‘رام سکھ داس ’’ سے پاس کیا۔ اس کے علاوہ بی۔اے کا امتحان امتیازی نمبروں کے ساتھ فیروز پور کے ‘‘آر، ایس،ڈی ‘‘RSDکالج سے پاس کپا۔
پاکستان ہجرت:
قیام پاکستان کے بعد اشفاق احمد اپنے خاندان کے ہمراہ فیروز پور (بھارت) سے ہجرت کر کے پاکستان آ گئے۔ پاکستان آنے کے بعد اشفاق احمد نے گورنمنٹ کالج لاہور کے ‘‘شعبہ اردو ’’ میں داخلہ لیا۔یہاں معروف اساتذہ سے علم حاصل کیا۔اْس زمانے میں بانو قدسیہ نے بھی ایم۔ اے اردو میں داخلہ لیا۔ یہ وہ دور تھا جب اورینٹل کالج پنجاب یونیورسٹی میں اردو کی کلاسیں ابھی شروع نہیں ہوئی تھیں۔
شادی:
جن دنوں اشفاق احمد گورنمنٹ کالج لاہور میں ایم۔ اے اردو کے طالب علم تھے۔ بانو قدسیہ ان کی ہم جماعت تھی۔ ذہنی ہم آہنگی دونوں کو اس قدر قریب لے آئی کہ دونوں نے شادی کا فیصلہ کیا۔ان کے والد ایک غیر پٹھان لڑکی کو بہو بنانے کے حق میں نہ تھے۔جس کی وجہ سے شادی کے بعد ان کو مجبوراً اپنا گھر چھوڑنا پڑا۔
تصانیف:
اشفاق احمد کی تصانیف میں افسانے، ناول، ٹی وی ڈرامے، ریڈیائی ڈرامے، فیچر اور سفر نامے شامل...

أحكام الحرابة و إختطاف الطائرات

This research article consist unique study regarding constitution of Human being character building in the thoughts of eminent philosopher Shah Wali Ullah (1703-1764). In present critique the focus has been made to explore how individual characters build in the specific environments? How surrounding effects on the character building? Moreover linkage of Islamic ‘IB└DA and its positive impact on the Muslim society has been explored. In interpretation of Shah Wali Ullah, All ‘IB└DA are like tools which lead to generate four basic ethics i.e purity and transparency capitulation, gainful and abstinence. These are the basic moral code which are the ultimate result of the four kind of ‘IB└DA i.e prayer, fasting, zakat and hajj. Muslim has inestimable inner power in the form of six lat┐’ef )اطلفئ, )which ultimately resulted upon the change of behavior. Character building are etiquettes, noble practices, decentness and good morality. It is generally refers to a code of conduct, that an individual group or society hold as authoritative in distinguishing right from wrong. Ethics are phenomenon values and can develop up to reasonable universal standards. Conduct in Islam governs all aspects of life and specifically addresses such principles as truthfulness, honesty, trust, sincerity, brotherhood and justice, while Islam forbid false, conspiracy, dodge, rude, irascibility, corruption. To materialize the virtues and disgrace the fake a role model prophet Muhammad (S.A.W) were deputed from Allah to guide the human being. So In present article character building in the theory of Shah Wali Ullah especially while in other Muslims scholars in general has diagnosed.

Dft Studies of Carbon and Nitrogen Based Cubic Antiperovskite Materials.

In this thesis, we present theoretical studies of antiperovskites ANCa3 (A=Ge, Sn, Pb), BCFe3 (B=Al, Zn, Ga), SnCD3 (D=Co and Fe) and MXY3 (M=Al, Ga, Ir, Mg, Pd, Pt, Rh; X=C, N; Y=Mn, Ni, Sc, Ti, Cr, Fe) as well as SbNCa3, BiNCa3, SbNSr3 and BiNSr3. The calculations are carried out with the full-potential linearized augmented plane waves plus local orbital (FPLAPW+lo) method within the framework of density functional theory (DFT) as well as Boltzmann’s theory. The exchange–correlation effects are treated by the local density approximation (LDA), generalized gradient approximation (GGA-PBEsol) and Engel and Vosko GGA (EV-GGA). Furthermore, the modified Becke and Johnson (mBJ) as well as improved mBJ potentials are used for the exact band gaps of the semiconductors. The relativistic effects in some of the compounds under study are explored by spin-orbit coupling. The consistency of the calculated results of the thermoelectric properties of SnCCo3 and SnCFe3 with the experimental results confirms the reliability of our theoretical calculations for the other investigated metallic antiperovskites, ANCa3 (A=Ge, Sn, Pb), BCFe3 (B=Al, Zn, Ga), SnCD3 (D=Co and Fe) and MXY3 (M=Al, Ga, Ir, Mg, Pd, Pt, Rh; X=C, N; Y=Mn, Ni, Sc, Ti, Cr, Fe). Our results for ANCa3 (A=Ge, Sn, Pb), BCFe3 (B=Al, Zn, Ga) and SnCD3 (D=Co, Fe) indicate that the thermopower of these materials can be enhanced by changing the chemical potential. The dimensionless figure of merit for the three nitrides approaches to 0.96 at room temperature, which predicts the usefulness of these materials in thermoelectric devices. Furthermore, the thermal conductivity of these compounds is minimum at room temperature for chemical potential of -0.25 eV to 0.25 eV, with maximum values of dimensionless figure of merit in this range. The striking feature of these studies is identifying a metallic compound, SnNCa3, with the highest value of Seebeck coefficient at room temperature out of all metals. Furthermore, electronic and thermoelectric properties of carbon and nitrogen based twenty metallic antiperovskites MXY3 (M=Al, Ga, Ir, Mg, Pd, Pt, Rh; X=C, N; Y=Mn, Ni, Sc, Ti, Cr, Fe) are investigated. We find high values of Seebeck coefficient and small values of electronic thermal conductivity for AlCTi3, AlNSc3, AlCNi3, AlNTi3, GaCCr3 and MgCNi3 between -0.25 and 0.25 eV chemical potential. These results show high dimensionless figure of merit in metallic materials and therefore, we predict these materials can be potential candidates for low temperature thermoelectric applications. Figure of merit for AlNTi3, GaCCr3, AlCNi3, AlNSc3, MgCNi3 and AlCTi3 materials reaches to 0.32, 0.25, 0.19, 0.19, 0.2 and 0.25 respectively, and hence are predicted to be low temperature thermoelectric materials. The structural, electronic and optical properties of antiperovskite semiconductors, SbNCa3, BiNCa3, SbNSr3 and BiNSr3 are also studied. The calculated lattice constants for these compounds are found consistent with the available experimentally measured values and other theoretical results. The band profiles show that all of these materials are direct band gap semiconductors with the band gap values of 1.1 eV, 1.09 eV, 0.92 eV and 0.81 eV for SbNCa3, BiNCa3, SbNSr3 and BiNSr3 respectively. The direct band gap nature reveals that they may be effective in optical devices and therefore the optical properties of these compounds like the real and imaginary parts of dielectric function, refractive index and absorption coefficient are calculated and discussed. Furthermore, the thermoelectric properties of these semiconductors are also calculated. Our results show high values of Seebeck coefficient for these materials between -0.25 eV and 0.25 eV chemical potential values.