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An Approach for Artificial Pancreas to Control the Type-I Diabetes Mellitus

Thesis Info

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Author

Farman, Muhammad

Program

PhD

Institute

The University of Lahore

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Mathemaics

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10601/1/Muhammad%20Farman%20%28DMAT01143004%29%20PhD%20Thesis.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725466377

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Currently diabetes mellitus is worldwide issue and challenges for diabetes community for healthy life. An effort is made to develop the idea of getting a fully automated artificial pancreas. The artificial pancreas is a developing technology to help patients with diabetes of type 1 diabetes mellitus (T1DM) to control automatically their blood glucose level by making available the alternative endocrine functionality of a healthy pancreas. The concept of controllability and observability for the linearized control system of human glucose insulin system is used so that we can have a feedback control for artificial pancreas. For the purpose of automatic artificial pancreas in the glucose regulatory system, we consider the Glucose Insulin (GI) Systems and Glucose Insulin Glucagon (GIG) systems. These models includes Augmented Meal Model (AMM), Reduced Meal Model (RMM), fractional order glucose insulin system, a composite model of Glucagon-Glucose Dynamics Model and Sorenson model being comprehensive model for Type-1 Diabetes Mellitus (T1DM). These models can be used to simulate a glucose insulin system for the treatment of T1DM. The Lyapunov Equation is used to check the stability analysis of the model. A fractional-order time derivatives model is presented for comprehensive glucose insulin regulatory model. A fractional-order state observer is designed for approximating the structure of a blood glucose-insulin with glucose rate disorder to show the complete dynamics of the glucose-insulin system with the fractional-order at α ∈ (0 < a < 1]. The developed method provides the observer estimation algorithm for a glucose-insulin system with unknown time-varying glucose rate disturbance. Numerical simulations are carried out to demonstrate our proposed results and show the nonlinear fractional-order glucose-insulin systems are at least stable as their integer-order counterpart in the existence of exogenous glucose infusion or meal disturbance. Controllability and observability of the linearized model are calculated under two different cases,for case 1 insulin is taken as an input and case 2, insulin and glucagon are taken as an input for the system. This played an important role in the development of fully automatic artificial pancreas by stabilizing the control loop system for the glucose-insulin glucagon pump. Proportional Integral Derivative (PID) controller is designed for an artificial pancreas by using the transfer function. According to the desire value, the algorithm of an artificial pancreas measures the glucose level in the blood of a patient by using glucose sensor that sends a signal to an insulin glucagon pump to adjust the basal insulin. A closed-loop system is tested in simulink environment and simulation results show the performance of the designed controller. We convert the Sorenson model to Sorenson model type 1 diabetes mellitus because this is the most comprehensive model in the Glucose Insulin Glucagon dynamics for human. This may play an important role in the development of fully automatic artificial pancreas and stabilize the control loop system for the Glucose Insulin Glucagon pump. It would be helpful for type 1 diabetic patients to control their diseases. The thesis is also review the state of art in hypoglycemia prevention and detection technique in the closed-loop artificial pancreas. Hypoglycemia is the major adverse effect of insulin therapy and therefore minimizing the risk of hypoglycemia, by applying different control and detection techniques is often considered in the development of artificial pancreas.
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یہ زخم اپنے دل کا تو سل بھی سکتا تھا

یہ زخم اپنے دل کا تو سِل بھی سکتا تھا
تُو کن اگر جو کہتا وہ مل بھی سکتا تھا
پژمردہ سا یہ غنچہ ہم دل ہیں جس کو کہتے
گر ساتھ وہ جو چلتا تو کھل بھی سکتا تھا

Awareness of the Benefits of Strategic Planning For Educational Institutions

This article aims to determine the benefits of strategic planning for Islamic educational institutions. The method used is a literature review, by collecting various supporting article references from national journals. The results of this study explain, if strategic planning can be made and implemented correctly and supported by leadership commitment, then strategic planning can provide benefits for Islamic educational institutions, including: (1) Strategic planning can strengthen the "critical mass" into a team that compact, because it is directed to adhere to basic values, main systems and common goals, (2) Strategic planning can help to optimize the performance of Islamic educational institutions, (3) Strategic planning can help leaders to always focus attention and adhere to a framework for overall improvement efforts continuous, (4) Strategic planning provides guidelines for daily decision making, and (5) Strategic planning always makes it easy to measure the organization's progress in achieving its goals of improving quality and productivity. The benefits of educational strategic planning are things that need to be considered to create quality Islamic educationh

Khushal Khan Khattak’S Educational Philosophy

Khushal Khan Khattak passed away about three hundred and fifty years ago (1613–1688). He was a genius, a linguist, a man of foresight, a man of faith in Al- Mighty God, a man of peace and unity, a man of justice and equality, a man of love and humanity, and a man of wisdom and knowledge. He was a multidimensional person known to the world as moralist, a wise chieftain, a great religious scholar, a thinker and an ideal leader of the Pushtoons. He was equipped with countless qualities as wisdom, honour, bravery, kindness, generosity, and self-respect. Moreover, he was a skillful man and wanted his individual to be skillful in various fields of life and be the owner of these qualities. He wants to build the moral character of his individual through the teachings of Islam. He himself was a practical and a devoted Muslim; therefore, he wanted that all individuals should develop love with Islamic injunctions. This versatile genius desired such education system, which should inculcate Qur’anic morals and high human values in social lives of students and of common human beings. He wanted to lay the foundation of a sound, healthy, and a moral society so that a welfare state may come into being. He was anxious to bring positive change in the behaviour of the people through his teachings, the real aim and objective of education. A meaningful and purposeful education should meet this aim. He emphasized that individuals should live a productive life. This is something which has been desired in our national education policies over the years. According to Imam Ghazali the aim of education is character building and personality development. He advocates the need of moral education both in theory and practice. This is the dominant theme of Khushal’s philosophy and he struggled to realize the same objective in his life. His educational philosophy also matches with holisitic / wholistic type of education, which is concerned with educating the whole person i.e. body, mind, soul, and spirit so that the individual may actualize his / her full potentials. Khushal is the staunch advocate of the same type of education as well. In the following chapters his approach toward education is discussed in detail. We will be well advised to examine & follow his recommendations in the reconstruction of our system of education. The Life of Khushal Khan Khattak: Chapter I attempt is made to present in brief Khushal’s early life & education, his origin, family background, his conflict with Mughal emperor and his imprisonment, his release from prison and life after imprisonment, His educational thoughts and his contributions to Pushto literature, Khushal and Iqbal''s Educational Philosophy, Chapter II is focusing on various definitions of educations. Before this discussion aims and objectives of various educational commissions and policies have also been given. Types of education, i.e. formal, informal, wholistic / holistic education have been discussed. Then Khushal''s and Iqbal''s philosophies and approaches with the instances of their poetry and prose have been given. Khushal''s Concept of Khudi: In Chapter III we have discussed Khushal’s concept of Khudi. Khudi is also one of the central and foundational terms in Iqbal''s poetry. A comparative account of these two great thinkers especially on the concept of Khudi is offered in this chapter. We have examined as to how khushal Khan has taken this word? What does he mean by it? And why he teaches it to his individual? Such queries are addressed in this chapter. Khushal''s Concept of Sovereignty: Chapter IV this chapter is devoted to Khushal''s concept of sovereignty. Here we have mainly focused on Khushal’s famous work: Dastar Nama. This book was written in the prison when Khushal was a prison in the fort of Rathanboor. In this chapter Al-Ghazali''s, Maulana Maududi’s and Qur''anic concept of sovereignty are also discussed. Here one can see as to what type of education Khushal recommends for his ideal sovereign / leader / ruler. Khushal''s Concept of Wisdom: In Chapter V wisdom, in the sense of intelligence and knowledge has been defined. Then it wisdom per se is also examined. Khushal''s concept of wisdom almost covers all it’s meaning In this chapter we shall see as to who qualifies as Dana, Aqalmand, Hukhiyar in Khushal’s view and whom he considers stupid, (Ahmaq, Nadan, Kam Aql, and Bay Waqoof). Khushal as interpreter of Islam: Chapter VI deals with Khushal’s scholastic approach towards Islam and his attachment with Islamic injunctions. He educates and recommends his individuals to know thy [their] Lord. For this purpose he stresses that first one should know oneself. If one succeeds in it, surely he will know his Lord. Its impact will ultimately be fell on the society .He desires a welfare Islamic society, in which each one helps and takes care of others. In order to realize this purpose, he teaches the youth higher human values in the light of Qur’an and Sunnah of the Prophet (PBUH). Khushal’s Moral Education: In Chapter VII Khushal’s moral education is discussed. Khushal is keen to build the morals of his individuals according to the teachings of the Qur’an and Sunnah. Aims and objectives of secular education and the objectives of Islamic education are also examined in brief in the chapter. Khushal as a preacher of peace and Proponent of perpetual struggle: In Chapter VIII we have tried to examine Khushal’s Philosophy of War and Peace. A general impression about Khushal Khan Khattak is that he was a warrior. No doubt, he was, but for what purpose he fought these wars? This chapter deals with such kinds of causes. Our contention is that he was a great preacher of Peace. He restored to war as a last resort & its purpose was the establishment of peace. His concept of peace was developed through the deep study of the Qur’an and Sunnah. He suggests different kinds of punishments for the violent groups and praises each step which should be taken for the purpose of peace. In the last portion the impact of wars and violence on the society has been discussed. Khushal’s Concept of Ideal Man: Chapter IX is devoted to Khushal’s concept of an Ideal Man. This is the last chapter of our study. It deals with all those attributes that Khushal wants to see in his ideal man. He wants that individuals should inculcate Godly attributes in themselves. He admires such attributes, which should present a picture of Tukhalliqu-bi-akhlaqillah. To him strenuous efforts, die-hard, strife for the establishment of peace and justice loving care & compassion for others are the ingredients for ideal man. These qualities he found in Hawk and Eagle, this is why he stresses his ideal man to be a Baz and Shabaz, thus its qualities of honour and self-respect will infuse in you and you will become khushal’s Nagyal.