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Analysis of Epidemiology Models by Non Standard Finite Difference Scheme and Laplace Adomian Decomposition Method

Thesis Info

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External Link

Author

Aqeel Ahmad

Program

PhD

Institute

The University of Lahore

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Pharmaceutics

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10600/1/Mian_M_Zeeshan_Javaid_Pharmaceutics_HSR_2018_IUB_Bahawalpur_14.09.2018.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725481573

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The present work has been planned through rational designing to develop targeted drug delivery system for alfuzosin HCl. Alfuzosin is basically selective antagonist of alpha 1 adrenoreceptors, indicated for treating benign prostatic hyperplasia. Its dose is 2.5 mg thrice daily and the treatment plan includes steady-state concentration of the drug throughout course of therapy. Due to readily absorbance and development of postural hypotension, it is not being indicated for treatment of hypertension. Through this research project, development of targeted systems like hydrogels and floating drug delivery system has been made in order to control the release of drug molecule. Regarding hydrogels; two different types of pH dependant three dimensional polymeric networks have been developed through free radical polymerization. In first phase; nine different formulations of pectin (Pec) have been evaluated in combination with acrylic acid and crosslinked through glutaraldehyde. In second phase; various grades of poly (ethylene glycol) (PEG) (Mw 400, 4000, 8000, 10000, 12000 & 20000) have been crosslinked with acrylic acid through N,N,,-Mehtylene-bis-acrylamide (MBAAm). After development of discs, these model systems were envisaged for various important elucidations like swelling studies, In-Vitro drug release analysis, Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (X RD) and Scanning Electron Microscopy (SEM). In order to predict releasing site and pattern; both dynamic and equilibrium swelling studies were conducted and implementation of various kinetic models has helped to elucidate kinetics of released molecule more efficiently. For both of the systems, frequency variations indicated by FTIR spectrum revealed interaction between the used polymers and monomers. Thermal stability has been reported by thermo gravimetric analysis while after copolymerization; increased enthalpy characters have been reported. In pectin based formulations, release of the drug followed zero order rates while in case of PEG based formulations; variations were reported in both rate and mechanism of drug release along with variations of molecular weights used. In both type of formulations, the drug release data is closely related to the swelling study’s findings and there is development of common character i.e. release of maximum amount of drug at pH 7.5. In floating drug delivery system, direct compression methodology has been adopted. The study has been aimed at developing floating system with non effervescent mechanism by using hydroxypropyl methylcellulose (HPMC) K100M, microcrystalline cellulose (MCC) PH 102, carbopol® and three grades of poly (ethylene glycol) (MW 10,000, 12,000 and 20,000). Various pre-compressional (angle of repose, compressibility index and Hausner’s ratio) and post compressional parameters (In-vitro buoyancy test, thickness, diameter, hardness, friability and In-vitro dissolution test) have been conducted to evaluate the suitability of developed dosage form for floating drug delivery system. The study is more focused towards evaluation of three grades of PEG (MW 10000, 12000, 20000) as all other parameters have been used as a constant quantity. Good matrix integrity has been found as all the formulations have presented total flotation time for more than 24 hours without disintegration. The formulation which doesn’t contain PEG has demonstrated first order along with fickian transport mechanism while all other formulations showed variation in their kinetic profile as the quantity and type of PEG varied. On the bases of revealed data of hydrogel and floating drug delivery system characterizations, it can be concluded that these systems are capable of delivering the drug molecule to the desired site in a predetermined mode of release.
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شہید کی جوموت ہے وُہ قوم کی حیات ہے

شہید کی جو موت ہے وہ قوم کی حیات ہے
زندگی تو گزر جاتی ہے، جو زندہ ہے اُس نے بالآ خرسفرآخرت کرنا ہے، جو سانس لے رہا ہے اُس نے جان، جان آفریں کے سپرد کرنی ہے، کوئی بستر مرگ پر ایڑیاں رگڑ رگڑ کر مر جاتا ہے، کوئی کسی ڈوبنے والے کو سہارا دیتے ہوئے خودلہروں کے سپرد ہو جا تا ہے۔ کوئی مزمّن بیماری کا شکار ہو کر حکیموں اور ڈاکٹروں کے نسخے استعمال کرتے ہوئے داعی اجل کو لبیک کہہ دیتا ہے۔ کوئی راہزن کے ہتھے چڑھ کر اپنے بچوں کو یتیم اور اپنی زوجہ کو بیوہ کر جاتا ہے۔ لیکن قابلِ صد افتخار ہیں وہ لوگ جو ملک و ملت کی خاطر سرحدوں کی حفاظت کرتے ہوئے دشمنوں کی توپوں کا نشانہ بنتے ہیں اور جامِ شہادت نوش کر لیتے ہیں۔شہید کوقرآنِ پاک میں بھی زندہ فرمایا گیا ہے بلکہ یہاں تک فرمانِ باری تعالیٰ ہے کہ انہیں مردہ گمان بھی نہ کرو، خودتو زندہ ہیں ہی لیکن موت کا ظاہری لبادہ اوڑھ کر اور نظروں سے دائمی اوجھل ہو کر قوم و ملت کو حیات ِنو کی نوید سنا جاتے ہیں ، شہید کی زندگی قوم کی حیات ہے۔ شہید بحثیت مجاہد سرحدوں کی حفاظت کرتا ہے، سرحدوں پر پہرہ دیتاہے، اقوام خوابِ خرگوش کے مزے لے رہی ہوتی ہے اور شہید توپوں کی گھن گرج میں رات کی ساعتیں گزار رہا ہوتا ہے۔ شہادت ایک زیور ہے، جس کے زیب تن کرنے سے جسمانی خدوخال کے علاوہ روحانی نکھار بھی آجاتا ہے۔ شہید اپنی قوم کے عروج میں کلیدی کردار ادا کرتا ہے۔
قوم اس وقت اپنے مستقبل کی درخشندگی کے لیے مستعد ہوتی ہے جب وہ ذہنی طور پر آسودہ ہو، فکری اعتبار سے توانا ہو اور اس قسم کے ماحول کی تشکیل کے لیے شہید کا وجود...

سیدہ زینب ؓ کا رسول اللہﷺ سے نکاح اور مستشرقین

Many western scholars have tried to interpret the Holy Qur’an into other languages of the world. William Montgomery Watt and Robert Spencer are included in the list of those commentators of the Qur’an who have presented their Quranic commentary in English language. But while interpreting the verses of the Holy Qur’an about the life, character and teachings of the Holy Prophet both the scholars have fabricated the teachings of the Holy Qur’an. Therefore, the main purpose of this study is to compare and analyze the interpretation of both western writers about the verses of Sūrah al-Aḥzāb in which the necessary information about the marriage of Prophet Muhammad with Hazrat Zainab has been discussed. Through the text analysis method and comparative and analytical approach, this article has raised some of the errors and propaganda elements found in the commentaries of both the Western scholars. The article proves that the writings of Western scholars like this need to be refined and scrutinized carefully in maintaining the sanctity of Islam and respecting the rights of the Prophet Muhammad (PBUH). This paper concludes that all such allegations are either based on fabricated historical reports or false interpretations and misunderstanding of the facts.

Study on Sustanable Livelihoods, Vulnerability and Adaptation to Climate Change in District Swat

Like any other developing country, Pakistan is confronting the problem of climate change. The unprecedented flooding of 2010 and other subsequent events directs to the fact that this region is most vulnerable to climatic hazards. Despite the fact and importance, the public concerns and understandings of the issue in the region is not studied yet. This research is based on a case study carried out in District Swat of Khyber Pakhtunkhwa province of Pakistan. The main objectives covering the study were i) to get insight of the public perceptions of climate change and adaptation in the study area and ii) to assess the various impacts of climate change on livelihood sources of indigenous communities. An attempt was made to utilize mixed methods approach to get an in-depth investigation of the underlying factors and determinants influencing the public understanding about climate change. Using stratified sampling technique, 25 union councils (wards) were selected from the nine tehsils (sub-districts) of the study area. Information was collected from 1066 households using structured questionnaire. The information was analyzed using SPSS (version 20) and the association between the climate change knowledge and demographic variables were explored using chi-square tests and Cramer’s V statistics. The study revealed that majority (88.5%) of the respondents were aware of the climate change in the area. Deforestation (37.2%), natural causes (29.7%) and combustion of fossil fuels (14.7%) were the main reported causes of climate change. Natural hazards such as floods (16.8%), dry spells (16.2%), vector borne diseases (10.8%), changes in biodiversity (10.5%), lower agricultural productivity 10.1%) and heat waves (9.9%) were among the major perceived impacts of climate change. A Significant relationship (p < .05) was found between the demographic variables and climate knowledge in the study area. The study also revealed that climate change has affected multiple livelihood resources in the study area. Climate induced hazards such as floods, droughts, extreme weather events and erratic rainfall are the main factors affecting livelihood sources in the study area. The floods of 2010 has resulted in a major setback to the overall socio-economic fabric of the area. The floods washed out large numbers of agriculture lands, crops and fruit orchards spreading havoc. Most of the hotels and other tourism infrastructure along xvii the River Swat got damaged as the result. The devastation left thousands of individuals jobless as their livelihoods were shattered by the floods. Adaptation measures dictates the various steps taken by the government and communities to adapt to the negative impacts of climate change. Government funded as well locally adapted measures have been found in the study area. After the severe flooding event of 2010, government departments are involved in multiple rehabilitation efforts. Watershed management, reforestation / afforestation, rehabilitation of the damaged water supply and sewerage systems, embankments of the River Swat, and construction of new reservoirs are some of the efforts commenced by the government. Locally adapted measures include changes in irrigations system, change in crop variety and seeds, change in the house structure, communal protection of the forest resources and grazing lands. Although a unanimous agreement about climate change was found in the study area, differing views about the causes and impacts of climate change among the survey respondents existed. The findings present ample evidence to materialize this prerogative. Perceptions and understandings of climate change is highly affected by the age, education and income level of the respondents. Elderly people are more knowledgeable about the causes and impacts of climate change as they have been observing the climate system since long. Educated people tend to blame anthropogenic causes for climate change compared to others who opt for natural causes. The demography of a study area is a major contributing factor to the understanding of climate change beliefs of a community. This research recommends that the role of environmental institutions should be enhanced at provincial level and should be extended to the district level. Public should be provided with climate education leading to better understanding of climate change and its impacts on their communities. Moreover, they should be made aware about the importance of forests, negative effects of deforestation and how to take care of these resources using individual and communal efforts.Further research is recommended to explore to the entire depth of the affected livelihood resources with emphasis on agriculture, fisheries and tourism sectors.