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Home > Antidiabetic Activity of Polyherbal Formulation in Alloxan Induced Diabetic Rats

Antidiabetic Activity of Polyherbal Formulation in Alloxan Induced Diabetic Rats

Thesis Info

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Author

Iftikhar, Asra.

Program

PhD

Institute

University of Agriculture

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Pharmacy

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/9348/1/Asra_Iftikhar_Pharmacology_2018_UAF_PRR.docx

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725507210

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Diabetes mellitus is a metabolic disorder characterized by high blood glucose level. Current study was designed to evaluate the effect of polyherbal formulation consisting of Swertia chirata (Chirata), Bunium persicum (Kala zeera), Artemisia absinthium (Afsanteen boti), Gymnema sylvestra (Ghurmar boti), Caesalpinia bonduc (kranjwa magz), Citrullus colocynthis (Kortumma), Sphaeranthus indicus (Mundi boti), and Cuminum cyminum (Safeed zeera) in alloxan induced diabetic rats. Qualitative phytochemical analysis, mineral analysis, proximate analysis and DPPH assay were performed for standardization of polyherbal formulation. Acute toxicity testing was also performed in order to adjust the dosage regimen. Sampling for different parameters was done at 0, 4th and 8th week of experiment to evaluate the effect of polyherbal formulation on diabetic rats through biochemical, antioxidant, histopathological and gene expression analysis. The effects of herbal formulation on different genes like Pdx-1, Ins-1 and IGF-1 involved in insulin signaling and Traf-4 and Mapk-8 involved in MAPK downstream c-Jun N terminal kinase (JNK) cascade were investigated by quantitative polymerase chain reaction (qRT-PCR) analysis to assess the underlying molecular mechanism of action of herbal formulation. The data was analyzed through analysis of variance (ANOVA). Based on significant results of ANOVA, DMR (Duncan’s Multiple Range) test was applied. The results have shown that polyherbal formulation played important role in the treatment of diabetes in alloxan induced diabetic rats. Polyherbal formulation produced anti-diabetic effect by reducing mean serum glucose (143.00±3.07) and increasing mean serum insulin levels (15.78±0.84) compared to diabetic group (+ve control) having mean serum glucose (518.00±5.31) and insulin levels (6.58±0.75) respectively at 8th week of treatment. Results of histopathological analysis of pancreas and liver showed that polyherbal formulation has potential to ameliorate the toxic effects of alloxan monohydrate. All the properties of polyherbal formulation make it a potential candidate for the treatment of diabetes. However, further research is required to elucidate its mechanism of action.
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میاں ایم اسلم

ایم اسلم
برعظیم پاک وہند کے مشہور ناول نگار اورافسانہ نویس میاں ایم اسلم مورخہ ۲۳/ نومبر ۱۹۸۳ء کو۹۸ سال کی عمر میں لاہور میں انتقال کرگئے۔پاکستان ٹیلی ویژن کے ایک پروگرام میں ان کے دیرینہ ساتھی اور ان کی تصانیف کے ناشر خواجہ بدرالاسلام فروغی نے مرحوم کے والد میاں نظام الدین کے ایک رجسٹر کے حوالے سے ان کی تاریخ ولادت۶/اگست ۱۸۸۵ء بتائی ہے۔
میاں ایم اسلم لاہور کے ایک رئیس گھرانے کے فرد تھے۔ان کے والد میاں نظام الدین لاہور کی کشمیری برداری کے سربراہ اوروسیع جائدادکے مالک تھے۔میاں ایم اسلم نے زراعتی کالج لائل پور(حال زرعی یونیورسٹی فیصل آباد) میں تعلیم حاصل کی اورمحکمہ انہار میں ضلع دار کی حیثیت سے ملازمت کاآغاز کیا۔یہ ملازمت انھیں راس نہ آئی اس لیے استعفی دے کر لکھنے پڑھنے میں مشغول ہوگئے۔میاں صاحب اپنے والد کے اکلوتے فرزند تھے اس لیے گھر میں روپے پیسے کی کمی نہ تھی۔
انھوں نے اپنی زندگی میں ڈھائی صد کے لگ بھگ ناول اور سیکڑوں افسانے لکھے۔مرحوم اپنے احباب سے کہا کرتے تھے کہ انھوں نے ایک لاکھ سے زائد صفحات لکھے ہیں۔
برعظیم پاک وہند کے تمام اہل علم کے ساتھ ان کے دوستانہ مراسم تھے۔ جس کے ساتھ ایک بارتعلق پیداہوگیا اسے مرحوم نے تازیست نبھایا۔ایک افسانہ نگار اور ناول نویس ہونے کے باوجود ان کی زندگی بڑی پاکیزہ تھی۔ہفتہ وارچھٹی کے دن ان کے احباب علی الصبح ان کے ہاں پہنچ جاتے اور اکھٹے بیٹھ کر ناشتہ کرتے۔احباب کی یہ محفل دوپہر تک جاری رہتی۔راقم الحروف بھی اس محفل کاایک باقاعدہ رکن تھا۔
میاں ایم اسلم لاہور کی ایک پرانی تہذیب اورروایات کے صحیح نمائندے تھے۔انھوں نے اپنے ناولوں میں اسلامی تہذیب کے خدوخال نمایاں کرنے کی بھرپور کوشش کی ہے۔عبدالماجد دریابادی فرماتے تھے کہ ایم اسلم نے ناول کو عبادت بنادیاہے۔
میاں صاحب نے دوشادیاں...

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