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Home > Application of Green Chemistry in the Synthesis of 2- 2- Fluorobiphenyl-4-Yl Propanoic Acid Derivatives

Application of Green Chemistry in the Synthesis of 2- 2- Fluorobiphenyl-4-Yl Propanoic Acid Derivatives

Thesis Info

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Author

Zaheer, Muhammad

Program

PhD

Institute

University of the Punjab

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Subject

Environmental Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/9226/1/Muhammad_Zaheer_Enviro_Chemistry_HSR_2017_UoP_Punjab_25.09.2017.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725519800

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Present study complies with different principles of green chemistry utilizing efficient instrumental techniques i.e; microwaves, ultrasonic waves and replacement of hazardous solvents with greener ones. The overall progress of chemical reactions achieved through application of green chemistry, was compared with the traditional methods. In the first part of this research work, synthesis of N’-benzylidene-2-(2-fluorobiphenyl)propanehydrazides was carried out for which, 2-(2-fluorobiphenyl-4-yl)propanoic acid was esterified to methyl 2-(2- fluorobiphenyl-4-yl)propanoate under the influence of microwaves followed by its hydrazinolysis. 2-(2-Fluorobiphenyl-4-yl)propanehydrazide thus obtained, was then reacted in an ultrasonic bath with different benzaldehydes to get a series of N’-benzylidene-2-(2- fluorobiphenyl)propanehydrazides. In the second series, 2-(2-fluorobiphenyl-4-yl)propane hydrazide was converted to 4-amino-5- [1-(2-fluoro-biphenyl-4-yl)-ethyl]-4H-[1,2,4]triazole-3-thiole followed by its reaction with different benzaldehydes under conventional and green technologies to get a series of 4- (benzylidene-amino)-5-[1-(2-fluorobiphenyl-4-yl]-4H-[1,2,4]triazole-3-thiole compounds. In another series, different substituted chalcones were prepared by clasian condensation method which were then reacted with 2-(2-fluorobiphenyl-4-yl) propane hydrazide in a mixture of water and ethanol to get a series of 2-(2-fluorobiphenyl-4-yl)-propionic acid(1,3- diphenyl-allylidene)-hydrazide. These reactions were conducted utilizing green technologies and were compared with using conventional methods. Comparison of both the conventional and microwaves/ultrasound assisted reactions indicates a significant reduction in reaction times and improvement in reaction yields. Besides, chemical characterization and X-ray crystallography of selected compounds, all the synthesized compounds were evaluated for their anti-oxidant potential [Total anti-oxidant activity, ferric reducing anti-oxidant power (FRAP) and total phenolic contents], and analgesic activities using (tail flick, hot plate and writhing methods) and most of them were found to possess potential as lead compounds for drug discovery.
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اُردو نعت میں’’ حسنِ کُن‘‘ کا اختصاص

اُردو نعت میں’’ حسنِ کُن‘‘ کا اختصاص
ڈاکٹر عارف حسین عارفؔ
نعت، کمالاتِ نبویﷺ کی تفسیر ہے۔یہ محض حضورﷺ کی منظوم توصیف کا نام ہی نہیں بلکہ حضور نبی کریمﷺ کے حقیقی کمالات کی ایسی پیشکش کا نام ہے جس سے ایمان میں تازگی اور بالیدگی اُسی وقت پیدا ہوتی ہے جب مدّاح کا دل رسول اللہﷺ کی محبت کے حقیقی جذبات سے سرشار ہو۔جذبۂ نعت دل میں محبتِ رسولﷺ کی شمع فروزاں کر دیتا ہے۔ اس سے جمالیاتی سرور کی تعبیر بھی حاصل ہوتی ہے۔ نعت توصیفِ مصطفیٰؐ کا وہ مستحسن انداز ہے جس میں الفاظ، زبان سے نہیں پلکوں سے ترتیب دیے جاتے ہیں۔ بقول راجا رشید محمود:
’’نعت سنتِ کبریا ہے ۔ قلم و زبان کا اس راہ پر قدم رکھناتلوار پر چلنا ہے ۔ اس فرض سے وہی شخص بطریقِ احسن عہدہ برآ ہو سکتا ہے جس کی نگاہ علم کے تمام شعبوں پر ہو، جو شریعت پر پوری طرح عامل ہو۔ جو رحمتِ عالمﷺ سے سچی محبت رکھتا ہو۔ جس شخص کوممدوحِ کبریا کی رفعتِ شان کا ادراک و احساس نہ ہو وہ نعت کیا لکھے گا،کیا سمجھے گا۔‘‘
نعت(ن ع ت) با لفتح(مؤنث)عربی زبان کا ایک مادہ ہے۔جو عام طور پر وصف کے مفہوم میں مستعمل ہے ۔ نعت کے معنی وصف کے ہیں۔ وصف میں جو کچھ کہا جائے اُ سے بھی نعت ہی سے تعبیر کیا جاتا ہے۔ وصف بیان کرنے والے کو ’ناعت‘ کہتے ہیں اور اس کی جمع’ نعات‘ ہے ۔ مضامین نعت کے مآخذ قرآن اور حدیث ہیں۔ قرآنِ مجید جس طرح اللہ تعالیٰ کی کتاب ہے اسی طرح وہ اسلامی ادب کی بھی پہلی کتاب ہے۔ اس میں رسولﷺ کے اوصافِ حمیدہ ملتے ہیں۔عربی کی مشہور لغت ’’المنجد‘‘ میں نعت کا مفہوم یوں بیان کیا گیا ہے:
’’نعتاً، تعریف کرنا،بیان کرنا، اچھی صفات دکھانا، اَنعَت،...

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