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Bioavailable Grain Zinc in Wheat Varieties of Pakistan and Strategies for Biofortification

Thesis Info

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Author

Hussain, Shahid

Program

PhD

Institute

University of Agriculture

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2013

Thesis Completion Status

Completed

Subject

Applied Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/531

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725582727

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Wheat grains are an important source of minerals and calorie intake especially for human population living in the rural areas of developing countries. Under the widespread zinc (Zn) deficiency in soils and humans, biofortification of wheat grains grown on Zn deficient soils of Pakistan was hypothesized as a possible solution to human Zn deficiency. The research project comprised of six separate experiments focusing on four major issues: i) estimating Zn bioavailability in grains of wheat varieties of Pakistan; ii) evaluating the relationship of grain Zn concentration with soil Zn status ; iii) optimizing rate and application methods of Zn to biofortify wheat grains; and iv) determining the effect of grain milling and flour extraction on Zn bioavailability. The bioavailability of Zn from the grains of selected wheat varieties was low as indicated by high phytate to Zn molar ratio ([phytate]:[Zn]) and low trivariate model of Zn absorption based estimated Zn bioavailability. Currently-cultivated varieties had higher grain yields and lower concentration and bioavailability of Zn than obsolete varieties of Punjab (Pakistan). Much of this variation was related to an increased grain weight in new varieties. Nutrient indexing of Zn in wheat crop and associated soils of cotton-wheat rotation zone of Punjab (Pakistan) indicated widespread soil Zn deficiency and a high risk of human Zn deficiency for the human population of the area. About 75% of surface and all the subsurface soil samples were deficient in plant available Zn resulting in a low grain Zn concentration (20±4 μg g −1 ). In another study, application of Zn significantly increased grain yield, grain Zn concentration and estimated Zn bioavailability while significantly decreased grain phytate concentration and [phytate]:[Zn] ratio in wheat grains. The levels of human requisite Zn concentration and estimated Zn bioavailability in wheat grains were estimated to be achieved at the soil Zn rates required for maximum grain yield (about 9 mg Zn kg −1 soil). Various Zn application methods, alone and in combinations, were evaluated in study 5. Soil Zn application increased grain yield up to 29%, grain Zn concentration up to 95% and estimated Zn bioavailability up to 74%. Foliar Zn application during grain development stage also greatly increased grain Zn concentration especially at lower soil Zn rates (<9 mg Zn kg −1 soil). Soil Zn application at a high rate and foliar Zn spray at heading increased Zn concentration (>50 μg g −1 ) and estimated Zn bioavailability (>3 mg Zn per 300 g flour) in wheat xiiigrains to levels generally desired for improved human nutrition. In the last study, Zn bioavailability from control and biofortified wheat grains was estimated in various grain milling fractions and flours of different extraction rates. Zinc and phytate concentrations and Zn bioavailability were significantly greater in bran compared to other grain milling fractions. There were severe losses in concentration and bioavailability of Zn from both control and biofortified wheat flour at lower flour extraction rates. Moreover, Zn bioavailability was remarkably higher in the biofortified wheat flour as compared to control and commercially available flours. Therefore, biofortified whole-grain flour was suggested for human consumption. As a whole, the project indentified the potential of wheat grown in Pakistan to supply optimum Zn for human nutrition by giving due importance to grain yield under optimum Zn application by suitable methods.
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خالد مسعود

آہ جناب خالد مسعود!!
یہ خبر علمی و دینی خصوصاً ترجمان القرآن مولانا حمید الدین فراہیؒ کے قدردانوں اور ان کے علوم و افکار کے شیدائیوں کے لیے بڑی غم ناک اور روح فرسا ہے کہ یکم اکتوبر ۲۰۰۳؁ء کو رسالہ تدبر لاہور کے مدیر جناب خالد مسعود صاحب کا انتقال ہوگیا، اناﷲ وانا الیہ راجعون۔
وہ مولانا امین احسن اصلاحی کے شاگرد رشید اور علمی وارث و جانشین تھے، انہوں نے اپنی زندگی فکر فراہی کی شرح و ترجمانی اور اس کی ترویج و اشاعت کے لیے وقف کردی تھی، ان کی وفات سے ہم قرآن و حدیث کے ایک بڑے خدمت گزار سے محروم ہوگئے۔
مرحوم کو جگر کی بیماری تھی، خون کی رگ بار بار پھٹ جاتی تھی اور خون کی قے ہونے لگتی تھی، آخر اس بیماری نے ان کا کام تمام کردیا۔
خالد مسعود صاحب ضلع جہلم کے ایک گاؤں ’’ﷲ‘‘ ۱۶؍ دسمبر ۱۹۳۵؁ء کو پیدا ہوئے، یہیں ابتدائی تعلیم حاصل کی اور ۱۹۵۱؁ء میں نوشہرہ سے فرسٹ ڈویژن میں میٹرک اور ۱۹۵۵؁ء میں اسلامیہ کالج لاہور سے فرسٹ ڈویژن میں بی۔ایس۔سی کیا، ۱۹۵۷؁ء میں پنجاب یونیورسٹی سے کیمسٹری میں ایم۔ایس۔سی کیا، ۱۹۵۸؁ء میں انڈسٹریل ریسرچ لیبارٹریز سے وابستہ ہوئے پھر مزید تعلیم کے لندن گئے اور ۱۹۵۹؁ء میں وہاں کے کنگز کالج سے کیمیکل انجینئرنگ میں ڈپلوما حاصل کیا، واپسی کے بعد ۱۹۷۴؁ء میں پنجاب یونیورسٹی سے علوم اسلامیہ میں ایم۔اے کیا، ۱۹۸۵؁ء میں قائداعظم لائبریری میں ملازمت کی، اس ے وابستگی کے زمانے میں بچوں کے لیے آسان زبان میں متعدد مفید اور معلوماتی کتابیں تحریر کیں، جو بہت مقبول ہوئیں اور بعض پر ان کو ایوارڈ بھی ملا، گو ان کتابوں میں فلکی طبعیات کی جدید ترین تحقیقات کے نتائج اور کائنات کے بارے میں نئے افکار و نظریات پیش کیے گئے ہیں تاہم اسلامی نقطہ نظر کو اوجھل...

الربافی بلاد غیرالمسلمة: دراسة فقهیة مقارنة

Islam is not a mere set of worships but it leaves no stone unturned to guide its followers regarding the social conduct be it politico-legal, sociocultural or economic etc to name a few. The interest-based transactions have been categorically rendered impermissible and unlawful by virtue of Quranic injunctions and authentic ahadith. In this article the issue of interest based transactions – Muslim to Muslim, Muslim to non-Muslim and vice versa, a Muslim resident of a non-Muslim state and a Muslim non-resident of a nonMuslim state – has been discussed in detail in the light of Quran, hadith and juristic rulings of the eminent Islamic scholars including the great four imams.

Synthesis of State Space Model for Human Cardiovascular System Using Bond Graph Approach

Cardio Vascular System (CVS) is a closed circulatory system responsible to provide the oxygenated blood to all the parts of the body and to collect the deoxygenated blood from all the parts of the body. It mainly consists of the heart, the blood vessels and the blood. It is one of the most important systems of the body and the heart being the chief organ; pumping the blood which carry all the vital nutrients to each and every cell of the body. The pumping action of the heart is regulated by a feedback mechanism called the baroreflex mechanism. Cardio Vascular diseases have a major impact worldwide; more than 55% of the total deaths in the world are due to malfunctioning of the CVS. Cardiovascular disease includes conditions that affect the structure or function of the heart, such as, coronary artery disease, heart attack, abnormal heart rhythms arrhythmias, heart failure, heart valve disease, congenital heart disease, heart muscle disease and many others too. Depending on the different malfunction conditions of the heart, artificial pumps and other invasive surgeries are proposed. The heart is a very vital organ and is also not easily accessible as it is located inside the ribcage. Due to this fact, the experimental monitoring of the functioning of the heart assist devices is impossible and is also life threatening. Therefore for proper designing of the required assistive devices, the very first requirement is the availability of proper mathematical model of the system which can clearly portrays the hemodynamic of the heart and can serve as an important test bed against which estimation and identification algorithms can be evaluated and controlled. A significant amount of valuable research work has already been undertaken regarding the mathematical modeling of the CVS and the baroreflex system. All these models cover many of the physiological characteristics but still there is a space for new strategies and improvement. The cardiac activity includes mechanical, hydraulic, chemical and electrical events; the modeling of such a multi domain system requires a unified modeling approach. The other limitations of the existing mathematical models may include the lack of cause effect relationship, complexity due to separate feedback loops, absence of fault diagnosis at element level etc. To overcome the above stated shortcomings in the existing models, a Bond Graph modeling approach to model the CVS and the baroreflex system has been proposed in this dissertation. The Bond Graph has proved to be an effective methodology for modeling the systems having subsystems of different physical nature. The benefit of using the Bond Graph for modeling is the ability to represent the circuits using flow, effort and energy conservation elements providing cause effect relationship. The fault diagnosis at element level also became possible. Consequently, in the Bond Graph technique there is a useful distinction between the reciprocal flow of influence inherent in the dynamics of the system and the feedback that arise by the design of system and therefore eliminates the complexity due to the separate feed back loops. Bond Graph modeling approach for the CVS was also proposed and presented by some researchers and had added remarkable contributions, but none of them analyzed the whole CVS on element basis and no idea was given for finding out the state space representation of the CVS using the cause-effect relation property of the Bond Graph. In this thesis, in addition to the complete Bond Graph model of the CVS and the baroreceptors, the time varying state space is also generated for these systems. The proposed state space model from the Bond Graph provides information about the internal state variables. The internal state variables are the smallest possible subset of the system that can represent the entire state of the system at any given time. Due to the in-depth analysis on element level and the information about the internal state variable the proposed model can provide a better platform for the CVS diagnostics, therapy selection, surgery and interventions.