Effects of Carica Papaya and Psidium Guajava Extracts on Hepato-Renal Performance of Streptozotocin- Induced Diabetic Male Albino Rats Carica Papaya and Psidium Guajava Extracts & Diabetic rats

The growing number of diabetes coupled with the harsh side effects of some synthetic drugs has led to the increasing search for alternative medicine which are relatively cheap with minimum side effects. Objective: To investigate the anti-diabetic effect of ethanolic extract of Carica papaya and Psidiumguajava extracts separately and in combination, and the effect of treatment on hepato-renal performance. Methods: Papaya and guava leaves were macerated in 98% ethanol for extraction. Results: The result showed that ethanolic leaf extract of P. Guajava and C. Papaya significantly (P< 0.05) reduced blood glucose level, Total Cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and significant increase in high density lipoprotein (HDL) as compared to diabetic control group. Serum activities of liver enzymes such as aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) was slightly elevated that indicate hepatotoxic nature of plant extracts. The level of gamma-glutamyl transferase (GGT), bilirubin and HbA1C level were restored to normal range. A slight reduction in body weight (P>0.05) of treated groups was observed. Serum urea and creatinine concentration was restored to normal level in treated rats with regeneration of kidney function. Conclusions: The study concluded that individual and combined plant extract show anti-hyperglycemic effect but the combined remedy at this dose show hepatotoxicity

Rules on Digital Trade in the Light of WTO Agreements

The World Trade Organization has been reluctant to respond to the different issues that come up due to integrating the digital economy into cross-border trading. The multilateral system’s slow reaction is principally due to the complicated, multifarious character of the digital economy or digital trade and country conflict over Regulation of the internet and digital growth problems. Agreements on International trade, especially those negotiated at the WTO agreements, are critical in establishing a protected, reliable, and dependable worldwide regulatory structure for digital trades. However, the framework of WTO was created before digital Trade arose. Unfortunately, there is no clear concept of digitalization in the norms of the WTO, especially GATS. The thesis will seek to explain how the World Trade Organization and, especially, the General Agreement on Tariffs and Trade implement data-restrictive policies and whether the WTO’s regulations can balance internet policy goals and Trade. It emphasizes the interdependence of the three essential concepts of internet governance that apply to cross-border flows of data, particularly security, privacy, and internet openness. It then presents a theoretical structure for aligning the General Agreement on Trade and Services with all those three objectives in order to enable an open and predictable structure for effective internet policies and digital trade. According to the dissertation, this approach is used with three types of data-restrictive measures: Cybersecurity related data restrictive, privacy related data restrictive measures, and online content control. This thesis demonstrates that the General Agreement on Trade and Service (GATS) can be implemented and interpreted wisely to comply with principles of security, privacy, and internet openness. For instance, commitments contained in the GATS's schedules of commitments can be understood technologically neutrally, allowing for either internet of openness or trade liberalization. Additionally, GATS access to market, National regulations, and non-discrimination’ standards (subject to pertinent exemptions and commitments from Member states) usually facilitate the opening of cross-border data exchange, thereby increasing the internet's openness. Moreover, under GATS's exceptions, Panels can differentiate between measures ostensibly related to online content control, privacy, and Cybersecurity and those necessary to accomplish these goals. Panels must take into account technical and legal information when conducting a comprehensive examination of data-restrictive measures under GATS provisions, such as reliance on knowledge and experience concerning the internet regulation. Due to the lack of international agreement on internet policy issues and the relatively archaic structure of GATS, the provisions of GATS are limited in their conformity with the concepts of security, privacy, and internet openness. Along with providing a more relevant interpretation of current GATS regulation, this dissertation suggests a multipronged strategy for further aligning GATS with the security, privacy and internet openness principles. For this purpose, it is essential to ensure that GATS clauses on transparency and mutual recognition are used effectively, that WTO law reforms are enacted to include a focus on cross border flows of data, and that alternatives to customary multilateral pathways, such as the creation of a non-binding WTO declaration on the flow of data and improved regulatory cooperation within pertinent global organizations, are considered. GATS, for Example, cannot solve all the problems relating to the data flow. However, this thesis argues that GATS can play a more significant part in stabilizing trade and policy of internet goals.