Flavonoids are the most common group of polyphenolic compounds in the human diet including fruits, vegetables, nuts and plant derived beverages, tea and wine. These compounds have been reported to possess a wide range of bio-activities. Structural variations of these flavonoids are associated with many different biological and pharmacological activities including antioxidant, anticancer, antiinflamatory, antihyperglycemic, antidiabetic, antibacterial, antifungal and antiviral activities. Antioxidant enzymes as well as non enzymatic antioxidants are the first line of defense against oxidative stress. This oxidative stress is the underline mechanism for diabetic complications. In recent years, the high therapeutic properties of flavonoids and their analogues have brought attention of chemists to synthesize various kinds of their derivatives by improving the existing synthetic methodologies.It is therefore, the aim of present study was to synthesis and characterize the novel flavonoids and their derivatives. These compounds were screened for their antioxidants potential and evaluate their antihyperglycemic activity. By using Claisen−Schmidt condensation, 2,5-dihydroxyacetophenone was allowed to condense with different aromatic aldehydes. Four kinds of products were isolated; chalcones (105, 106, 108, 110, 115, 119, 121), flavanones (107, 109, 111, 120, 123), Arylmethylidene flavanone (112, 113, 114, 116, 117, 118, 122, 124, 127, 128) and 2-Arylmethylidene indanones (125, 126). A series of chalcones (131-135) was also synthesized by reacting 2 hydroxy-5-nitro acetophenone with different aromatic aldehydes. The synthesized chalcones 134 underwent cyclization in the presence of iodine to obtain compound 136. Compound 105 was reacted with hydrazine hydrate to obtain 2-(5-(2-nitrophenyl)4,5-dihydro-1H-pyrazol-3 yl)benzene-1,4-diol (129) and compound 108 was reacted with hydrazine hydrate to form 2 (5-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,4-diol (130). The compound (125) was reacted with different N-substituted-2-bromoacetamide (137-139) to form compound (144-146). After reacting 8-acetyl-7-hydroxy-4-methylcoumarin (142) with 2′-Bromo-N-benzylacetamide (137), the product 2-[(8-acetyl-4-methyl-2-oxo-2H-chromen 7-yl)-oxy]-N-phenylacetamide (143) was obtained. All the synthesized compounds were characterized and confirmed through spectroscopic analysis i.e., Fourier-transform infrared spectroscopy (FTIR), Nuclear magnetic resonance (NMR) spectroscopy and Electron Ionization Mass Spectrometry (EIMS). The compounds 105-126, 129, 130 and 131-135 were checked for their antioxidant potential by α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging, Iron chelating activity, Iron chloride (FeCl3) reducing power activity, Phosphomolybdinum assay and 2,2′ azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) activity. Among all the synthesized compounds, the chalcones 105, 106, 108, 110, 115, 119, and 121 showed excellent antioxidant activity. The chalcones 105, 110 and 115 exhibited better antioxidative behavior than trolox and ascorbic acid. The Oral glucose tolerance test (OGTT) was performed in normal hyperglycemic rats for compounds 105, 106, 107, 108 and 109. The compound 109 exhibited good activity in normal hyperglycemic rats while the compound 105 showed significant activity in streptozotocin (STZ) induced diabetic rats as compared to reference Glabenclamide. For in silico studies, Quantitative Structure-Activity Relationships (QSAR) were performed for compounds 105-126 and 131-135. The comprehensive intra molecular charge transfer has been perceived from the highest occupied molecular orbitals (HOMOs) to the lowest unoccupied molecular orbitals (LUMOs). The smaller ionization potential (IP) and bond dissociation energy (BDE) values for compound 105, 106, 107, 108 and 109 revealed that these compounds would show proficient antioxidant behavior which is in good agreement with the antioxidant experimental data. Experimental and computational investigations concluded that compound 105 might be an effective antihyperglycemic agent because of its antioxidative nature and smallest ionization potential.
پرانے وقتاں دی گل اے کہ اک وار حضرت شیخ عبدالقادر جیلانی بال پن وچ علم حاصل کرن لئی اک قافلے دے نال بغداد توں روانہ ہوئے۔ ٹرن ویلے آپ دی والدہ محترمہ نے چالی دینار آپ دی قمیض دے اندر سی دتے تے نصیحت کیتی کہ پتر ہمیشہ سچ بولنا ایں۔ بھانویں کنی وی مشکل کیوں نہ بن جاوے۔ اتفاق دی گل اے کہ رستے وچ اوس قافلے اتے ڈاکواں نے حملہ کر دتا تے سارے بندیاں دا مال کھو لیا۔ جدوں ڈاکو واری واری پر بندے دی تلاشی لے رہے سن تاں اک ڈاکو نے آپ کولوں پچھیا کہ تیرے کول کیہ اے؟ آپ نے جواب دتا میرے کول چالی دینار نیں۔ جو میری والدی نے سفر تے روانہ ہوون توں پہلاں میری قمیض وچ سی دتے سن۔ ڈاکو نے آپ دی ایس گل اتے اعتبار نہ کیتا۔ ہر جدوں ویکھیا تاں واقعی قمیض اندر دینار سن۔ ڈاکو بہت حیران ہویا تے آپ نوں پھڑ کے اپنے سردار کول لے گیا۔ تے ساری گل سردار نوں دسی۔ سردار نے آکھیا۔ توں سچ بول کے اپنی رقم کیوں گوائی۔ جے توں جھوٹ بول دیندا تاں تیرے اُتے کسے نوں شک وی نئیں سی ہونا کہ تیرے کول اینی وڈی رقم اے۔ آپ نے فرمایا کہ میری والدہ نے سفرو شروع کرن ویلے ایہہ نصیحت کیتی سی کہ جھوٹ نئیں بولنا۔ ہمیشہ سچ بولنا ایں۔ میں جھوٹ بول کے اپنے والدہ دے حکم دی خلاف ورزی نئیں کر سکدا۔ ایس جواب نے سردار نوں بہت متاثر کیتا۔ اوس دے دل وچ خیال آیا کہ ایہہ منڈا اپنی ماں دے حکم دی خلاف ورزی نئیں کرسکدا۔ میں اپنے ربّ دا ایناں نافرمان آں کہ اوس دی کوئی وی گل نئیں مندا۔ سردار نے اوسے ویلے سچے دل توں توبہ کیتی تے لٹیا...
am offers a complete code of life. It covers all aspects of human life.
Literature, Art and Aesthetics are all a very crucial part of man's life.
Quran and Hadith have had a revitalizing impact on literature. Besides
being the core source of 'the guidance', they are nonetheless significant
literary pieces. Our Holy Prophet (PBUH) himself devoted special focus on
the development and promotion of various genres of prose like
letter-writing, oratory, proverbs, etc. However, poets have been
condemned in the Quran. Our Holy Prophet himself has kept a distance
from poetry. So interestingly poetry has become a rather controversial
literary genre among Muslims.
Therefore in this article we make an effort to see the real Islamic
perspective regarding poetry and poei in light of its original and primary
sources Quran and Hadith
This dissertation is concerned with the use of current Smart Antenna Systems (SAS) for utilizing the spatial dimensions of the wireless channel to improve upon the capacity of wireless systems. This enhancement is achieved for downlink Multiple Input Single Output (MISO) wireless channels by augmenting link quality by the provision of beamforming, diversity and interference cancellation gain in SAS. One such system consists of a Transmit Beamformer (TB) at the base Station (BS) which provides beamforming gain, interference cancellation gain and, on provision of feedback from the Mobile Station (MS), gives beamforming gain even in channels undergoing independent fading at the antennas of BS. The beamforming gain of the TB is reduced in those fast fading channels that are uncorrelated across the antennas of the Transmit Antenna Array (TAA). Currently researchers are actively pursuing TB techniques based on element space beamforming. In an Element Space Transmit Beamformer (ES TB), each antenna weight of the TAA is individually adaptive to the varying channel conditions. This thesis, in contrast, presents an Adaptive Transmit Beamspace Beamformer (ATBBF) that uses beamspace beamforming to provide beamforming gain. An ATBBF consists of several orthogonal Transmit Beamformers (TBs) on the TAA. In beamspace beamforming a specific set of antenna weights determines an orthogonal direction of the TB. This weight vector (corresponding to each orthogonal beam) is further weighted by an adaptable weight. This weight, called the beamspace weight, thus adaptively weighs one orthogonal beam and is updated based on the changing channel conditions. An ATBBF deploys this set of orthogonal beams in space to transmit signals to a MS. The superposition of adaptively weighted orthogonal beams in space forms the beam pattern of an ATBBF directed in the desired direction. Simulations in single, double and triple multipath static wireless channels demonstrate the unique evolution and convergence of the ATBBF''s beam pattern in relation to the convergence of its beamspace weights. The relationship between the magnitude and convergence time of a beamspace weight upon the multipath wireless channel is also elaborated. Furthermore, for the above channels, performance curves of both implementations of an ATBBF i.e. Full Dimension Adaptive Transmit Beamspace Beamformer (FD 14ATBBF) and Reduced Dimension Adaptive Transmit Beamspace Beamformer (RD ATBBF), along with that of an ES TB (having similar feedback mechanism) are simulated with uniform initial adaptable weights. Their analyses reveal that contrary to the RD ATBBF and ES TB, the FD ATBBF converges to optimum performance in all channels. The FD ATBBF also has a lesser convergence time than the TB in most double and triple multipath channels. The performance metric of an ATBBF is derived and analyzed in a dynamic channel undergoing Rayleigh fading independently at the antennas. A performance comparison between a FD ATBBF, RD ATBBF and an ES TB is made in terms of convergence and tracking of various slow and fast fading channels by simulations. Comparisons show that the FD ATBBF gives a performance equivalent to that of an ES TB and outperforms the RD ATBBF. Thus the FD ATBBF can provide beamforming gain and fading diversity similar to that of an ES TB. The performance of the FD ATBBF improves on increasing the number of antenna elements of the TAA from two to four i.e. from 2.91 dB in slow fading to 0.01 dB in fastest fading dynamic channel. Bit Error Rate (BER) studies for the above dynamic channels in the presence of noise are carried out to compare the BER curves of the FD ATBBF, ES TB and RD ATBBF with non beamforming techniques like Space Time Codes (STC). The studies confirm the performance analysis above by noting that the BER curves of the FD ATBBF and ES TB are similar in slow and fast fading channels and both outperform the RD ATBBF. The FD ATBBF also gives a gain of 2.2 dB and 4.8 dB over STC in slow fading for two and four antennas respectively. Furthermore, for four antennas, the FD ATBBF and RD ATBBF offer double data rate than the best performing STC technique, under constrained bandwidth requirements. In order to improve the performance of an ATBBF in fast fading channels for two antennas, a simple combination of an ATBBF with STC called the Space Time Coded Adaptive Transmit Beamspace Beamformer (STCATBBF) is proposed. This technique is made possible by utilizing the orthogonal beams of an ATBBF. The BER curves of the STCATBBF are simulated and compared with the FD ATBBF and STC in fast and slow flat fading channels. It is shown that in fast fading channels the STCATBBF gives a gain of 2.2 dB to 5.4 dB over the FD ATBBF, while in slow fading it outperforms STC .