Momentum of Ajwa Dates towards Cardiovascular Diseases Momentum of Ajwa Dates towards Cardiovascular Diseases

Cardiovascular diseases (CVDs) are the top most cause of morality around the world.  It is predicted that the number casualties from CVDs will increase to more than 24 million till 2030 people. Medicinal plants provide the major raw materials for medicine preparations. They are gaining high consideration due to their effectiveness and increasing cost of modern medicines. Many successful drugs are plant based, including aspirin from the willow bark, morphine from opium poppy, quinine from the cinchona bark, and digoxin from the foxglove. According to World Health Organization (WTO), ~70% to 80% of people around the world rely on herbal sources for the treatment of their disease. Plant sources are endorsed due to the fact that they contain an optimal amount of  antioxidants and phytochemicals that help to avoid and treat many diseases. Phoenix dactylifera L. Particularly Ajwa variety, is the most rich in phytonutrientsthat can benefit to control many cardiovascular diseases. It contains6 vitamins (vitamin A, C, B1, B2, B3 &riboflavin), high amount of fibers, Potassium, Magnesium and 23 amino acids which play a healthy role towards hypertension, muscular contractions, and blood pressure control. It has been studied that Niacin (B3) helps to control cholesterol and low density lipoprotein levels (LDL), as high cholesterol is the one of the main cause of cardiovascular diseases so, Ajwa could be a vital regulatory source. According to the findings of Sabbah M. Et al, Ajwa extracts significantly improved the DNA integrity and also reduced the cardiomyocytes congestion, edema and the cellular stress wielded on cardiac muscles resulting the restoration of cardiomyocytes architecture in Doxorubicin (DOX) induced cardiotoxicity in rats. Research done by Alqarni et al, proves that Ajwa extracts has successfully decreased the LDL‐C, VLDL‐C, and triglycerides concentration. Additionally, treatment with ajwa pulp also improved the HDL‐C level and antioxidant enzymes activity. In another invivo study, Ajwa preparation has successfullydecreased the diclofenac-induced pulmonary and hepatic instabilities. Vitamin-K play important role in blood coagulation, and in case of anticoagulant therapy, activity of vitamin-K controlled by drugs (warfarin) that sometimes causes serious side effects. According to the reported data, Salicylic acid is the vitamin-K antagonist and has capability to block the action of vitamin K during the coagulation pathway. Dates contain ~3.75 to 4.50 mg/100 g of salicylic acid. Thus, providing anticoagulation effect too. So, the limelight of the reported data provides an enough reason that plants can be used as primary source of drug designing for the cardiovascular disease. They hold true momentum to address the increasing healthdiseases, which cannot be lost to distraction or apathy. Fight against the burden of CDVs, is affecting all countries and specially, under developing and the poor countries.

Opto-Electronic Response of Spinel Compounds Through Modified Becke-Johnson Exchange Potential

Theoritical Study is carried out on some of the Spinel compounds. These compounds have wide range applications in various optoelectronic devices, industries and ornamental purposes being natural gem stones. For the better performance and practical applications of these Spinel compounds the newly suggested approximation is used known as the "modified Becke-Johnson potential approximation (mBJ)" as presented in the Wien2K computer package which is commercially available. The optoelectronic responses of SnX2O4 (X= Mg, Zn), MgIn2O4, SiZn2O4, GeX2O4 (X= Mg, Cd) and CdX2O4 (X= In, Ga, Al) are calculated and presented. The calculated total and partial density of states of the studied compounds within only the mBJ approximation is a prototype since the patterns of the density of states for all approximations are almost similar to each other. In MgIn2O4 charge distribution between the cation and anions is uniform; hence the bonding nature is mainly covalent. Electron effective masses of CdX2O4 are calculated, CdGa2O4 has higher mobility of charge carriers as compared to CdAl2O4 and CdIn2O4. A unique character of cation replacement is observed in these compounds. If we replace the cation in all of the above studied compounds the band gap and its dependent optical parameters change which demonstrate the wide range applicability and appropriateness of these compounds in various optoelectronic instruments. All of the herein studied materials are found to have direct band gaps and hence most suitable for optoelectronic instruments.