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Chemistry of Stem of Murraya Koenigii

Thesis Info

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Author

Hassan, Farkhanda

Program

PhD

Institute

University of Karachi

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2017

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/12971/1/Farkhanda_Hassan_Chemistry_2017_HSR_24.09.2019.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725718982

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The present phytochemical investigations described the isolation of chemical constituents from the stem of indigenous plant Murraya koenigii(L.) Spreng which is commonly known as curry plant. This thesis is divided into two parts. PART A Phytochemical studies of Murraya koenigii PART B Pharmacological investigation of isolated compounds In Part A, the introduction describes biosynthesis of carbazole alkaloids, their pharmacological importance and list of previously isolated chemical constituents.In the present study, total eleven different compounds have been isolated from the stemof M. koenigii. Among these isolated compounds eightwere identified as new compounds namely, aronine (66), afifine (67), jerinine (68), ferinine (69), atinine (70), zolidine (71), osinine (72) and2-methyl-3-(1-methyl cyclohex-2-en) propanol-ol (73). Moreover,other three known compoundsmurrayanine (1), mahinimbine (3) andgrinimbine (14) were also identified during this phytochemical work. In Part Bpharmacologicalactivities namely, antifungal and antibacterial and antioxidant activities of isolated compounds have been studied. The three compound girnimbine,murayanine and afifine showed antifungal activities and murrayanine and jerinine showed antibactrial activities against the tested strains. Furthermore, murrayanine, ferinine, girimbine, afifine and jerinine exhibited positive antioxidant activity.
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ڈاکٹر راجندر پرشاد

ڈاکٹر راجندر پرشاد
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