نقشِ پائے شہِ ابرارؐ ؛ قمر کی رونق
کہکشائوں میں ڈھلی ، راہ گزر کی رونق
یہی دیواروں کی زینت ، یہی در کی رونق
ذکرِ سرکارِؐ دو عالم سے ہے گھر کی رونق
نقشِ نعلین نبیؐ سے ہے مدینے کی چمک
اسی دستار سے ہے میرے بھی سر کی رونق
رحمتِ کون و مکاںؐ جانِ دو عالم ٹھہری
یادِ محبوبِ خداؐ دل کے نگر کی رونق
آپؐ کے دم سے ہے اے صاحبِ لولاک لماؐ!
بحر و بر ، حجر و شجر ، شام و سحر کی رونق
لفظِ کُن ، روزِ ازل ، لوح و قلم ، عرشِ عُلی
آپؐ مخلوقِ خدا ، جنّ و بشر کی رونق
عدسئہ آنکھ میں ہے نورِ مُنوّر اُنؐ کا
نورِ محبوبِ خداؐ ، حسنِ نظر کی رونق
روزنِ چشمِ عقیدت سے حقیقت دیکھو
ذاتِ محبوبؐ سے اللہ کے گھر کی رونق
رونقِ چہرئہ اُمّت ہے شفاعت کے سبب
ہے ندامت سے بھری دیدئہ تر کی رونق
کاش عرفانؔ کی پلکوں کو بھی ہو جائے عطا
اُنؐ کی راہوں کو ملی لعل و گہر کی رونق
Tujuan dari penelitian ini adalah untuk mendeskripsikan kesulitan membaca yang di alami siswa kelas V SDI Wairotang dan untuk mengetahui faktor-faktor yang menghambat siswa dalam kesulitan membaca. Penelitian ini menggunakan pendekatan kualitatif dengan jenis metode penelitian deskriptif kualitatif. Sumber data dalam penelitian ini adalah guru dan siswa SDI Wairotang yang berkesulitan membaca. Teknik pengumpulan data menggunakan teknik wawancara dan dokumentasi. Teknik analisis data menggunakan Miles and Huberman yaitu mereduksi data, menyajikan data dan penarikan kesimpulan. Hasil penelitian yang menunjukkan kesulitan yang dialami siswa adalah membaca belum lancar, mengeja, dan penggunaan tanda baca kurang tepat dan faktor-faktor yang menghambat siswa dalam membaca yakni kurangnya minat belajar membaca serta kurangnya dukungan keluarga dalam belajar membaca. Berdasarkan hasil penelitian yang dilakukan maka dapat disimpulan bahwa kesulitan-kesulitan siswa dalam membaca dan faktor penghambat dalam membaca di kelas V SDI Wairotang yaitu: belum lancar membaca, mengeja dan penggunaan tanda baca yang kurang tepat serta kurangnya minat belajar membaca dan kurangnya dukungan keluarga dalam belajar membaca.
Disease associated risk factors in premenopausal women includes professional and household stresses. While in post menopausal women the major factor is sedentary life style. Physiological characteristic have shown that the major risks associated with the aggressiveness of tumor are the receptor status especially triple negative (ER, PR and her2/neu) in both premenopausal and post menopausal women. Techniques of ELISA SEC, HPLC were tried to find out the method for estimation of the level of MUCI/CA15- 3 that showed an early detection and that was also economical. Computational protein modeling was used to predict secondary structure of MUC1. Predicted secondary structure of MUC1/CA 15-3 contains 6.0% helix, 7.9% strand or β-pleated sheet and 86.1% loop. Percentage composition shows an increased number of alanine, proline, serine, tyrosine, valine and glycine in helix, strand and turn or loop structure that indicates its basic and hydrophobic characteristics. MUC1/CA 15-3 comprises of an extracellular domain and a membrane associated domain. A junction of 3 amino acid units i.e. Cys-Gln-Cys between the extracellular subunit and transmembrane subunit is also observed. This motif is necessary for surface expression. The extracellular subunit consists of a tandem repeat unit that consist 20 amino acid residues i.e sapdnkpags and tappahgvts. This region of MUC1 may be used as vaccine for breast cancer. The subcellular subunit of MUC1 mainly consists of immunodominant DTR motif at 922 postion of the domain, is haeavily glycosylated and may protect the cell from any of the foreign body or tumor cell. The other subunit of MUC1/CA 15-3 consists of 17 amino acid residues. This subunit is associated with the plasma membrane. xixPost translational modifications (glycosylation, phosphorylation and myristoylation) are mainly observed in extracellular subunit. Several phosphorylation sites, Myristoylation sites and some glycosylation sites of tandem repeat region were predicted in MUC1/CA 15-3. It was observed that due to these modifications, the protein performed different functions. Alignment of the sequence of MUC1/CA 15-3 with the other family member of mucins (MUC2- MUC12) shows highest homology of MUC1/CA 15-3 with MUC4. The property of breast tumor to produce mucinous antigen was used for the synthesis of vaccine using the experimental mice. Electrophoretic technique was used to confirm the production of antibody that may be effective against antigen of MUC1/CA 15-3. The conclusion is that CA 15-3 is a transmembrane glycoprotein having basic and hydrophobic charecterstics. The most important part of this protein is extracellular and transmembrane subunits. These subunits of protein undergo posttranslational modification and are important in immunization and vaccine formation.