To broaden applications, increase environmental friendliness, reduce cost, and sustainability, water is a tempting choice as a solvent for waterborne polyurethane (WPU). WPU is a revolutionary step in the reduction of volatile organic contents in the field of green polymer chemistry. In the first part of the dissertation, eco-friendly emulsifier-free biodegradable WPU elastomers were synthesized via a two-step prepolymer process by using renewable ionomer lysine and aliphatic diamines as a chain extender (CE). Different series of WPU were synthesized by changing molecular weight (Mw) of soft segment (SS), NCO/OH ratio, length of CE, and methyl methacrylate (MMA) concentration. The focus of this research was to study the dependence of mechanical properties, thermal, surface, structural, and the drug delivery applications of WPU on length of CE, size of the hard segment (HS), NCO/OH ratio (3-4), molecular weight (Mw) of polyethylene glycol (PEG, Mw varies from 650 to 2000 g/mol), and concentration of MMA (10%-40%). Biodegradable WPUs were employed as the stimuli-responsive drug release matrix, loaded by cisplatin as a model anticancer drug. Sustained-drug release was studied by changing pH (4.4-7.4), polarity of drug release medium (solvents), temperature, concentration of MMA, Mw of PEG, length of CE and NCO/OH contents (3-4). So, drug release rate was adjusted under different conditions with the help of stimuli-responsive drug release WPU matrix. Semiconductor nanocrystals are potential resources for clean energy conversion and storage. In the 2nd part of this dissertation, the author focuses on the controlled synthesis of different magnetic nanoparticles (NPs) and robust photocatalytic systems, microwave absorber, and construction of anode material for a lithium-ion battery. Several scientific research achievements attained are as follows: (1) Eco-friendly, biocompatible, water dispersible, impurity-free, single-phase, citric acid surface capped, ultrafine-superparamagnetic magnetite nanoparticles (USM NPs) were prepared. USM NPs were synthesized by modifying wet chemical facile co-precipitation green itinerary. Size of USM NPs was tuned from 11-15 nm by controlling pH of reaction media. Citric acid, polyaniline, trimethoxy silyl propyl methacrylate, polyacrylamide, and polyamine surface-modified USM NPs ferrofluid was formed for different applications. Novel self-assembled morphologies of magnetite (Fe3O4) were controlled by using a facile, template-free hydrothermal pathway under optimized conditions engaging different precursors with the best control of morphology and electrochemical properties. A detailed study of the thermal, Controlled Synthesɨs and Potentɨal Applɨcations of Eco-friendly Polyurethane & Magnetɨc Nanomaterials xiv magnetic, dielectric, optical, and biological properties of USM NPs were conducted. Excellent reflection loss values confirmed that these USM NPs are promising microwave absorber which is very useful in satellite communications and EMR pollution control. USM NPs were further investigated for potential photocatalytic applications in dye degradation under visible light with detailed mechanism. (2) In the electric energy storage technology, lithium-ion battery (LIB) is a revolutionary step for making a green environment. The anodic material for LIB was made by using graphene-magnetite-polyaniline nanocomposite (Gr-Fe3O4-PANI NC) as a high-performance electrode. Gr-Fe3O4-PANI NC based LIB has shown superior reversible current capacity of 960 mAh g−1 and high cycling stability along with more than 99% coulombic efficiency even at a high current density of 5 Ag−1, low volume expansion, and excellent power capabilities over 250 cycles. (3) For the photocatalytic water oxidation application, morphologically-controlled pseudobrookite Fe2TiO5-TiO2 yolk-shell hollow spheres were synthesized by using facile sacrificial hard template strategy. The Fe2TiO5-TiO2 yolk-shell hollow spheres have exhibited high oxygen evolution reaction (OER) rate of 148 μmolg−1h−1 under UV-Vis light. So, designed Fe2TiO5-TiO2 yolk-shell hollow spheres are beneficial for the photocatalytic water oxidation. (4) Ultrapure hexagonal BaFe12O19 nanoferrite was prepared by a facile coprecipitation route. Crystallite size was found to grow from 50 nm to 78 nm when the annealing temperature increased from 800 °C to 1000 °C, respectively. The EMR absorption was obtained at a frequency of 2-18 GHz from VNA which showed maximum absorption of -26.52 dB at a frequency of 5.79 GHz
موضوع3:زبان کیا ہے؟ زبان کے معنی ومفہوم، تاریخ و اہمیت انسان اور انسانی خیالات میں اگر اس کا مطالعہ کیا جائے تو ہمیں پتہ چلتا ہے کہ انسان بچپن سے لے کر لڑکپن جوانی بڑھاپے اور اور اپنی عمر کے آخری لمحے تک زبان کا استعمال کسی نہ کسی صورت کرتا ہے۔ مثلا۔جب بچے کو کھانے پینے کی حاجت ہوتی ہے تو وہ بچہ جو بول کر اپنا مدعا بیان نہیں کرسکتاجیسے کہ بڑے کرسکتے ہیں مگر اس کے باوجود و ہ ہاتھوں کے اشاروں سے یا ٹانگوں کے اشاروں کی مدد سے مختلف حرکات سے مدد لیتا ہے۔ بچہ اشاروں اور حرکات کے ذریعے سے دوسروں کو متوجہ کرتا ہے۔ما ںاس کے اشاروں کو سمجھتی ہے۔ماں تھپکی یا لوری دے کر سلا دیتی ہے۔بڑا ہونے کے بعد وہ چیزوں کو مختلف نام دینا شروع کردیتا ہے اور پھر وہ وہی نام قبول کر لیتا ہے جو معاشرے میں رائج ہوتا ہے۔وہ معاشرے میں اپنے آس پاس کی زبان سن لیتا ہے۔اگروہ عام لوگوں سے متعلقہ ہے تو اس کی زبان بھی عام لوگوں جیسی ہوگی اگر خاص ہوتو اس کا اثر زبان پر پڑے گا۔زبان انسان کی ذہنی و جسمانی نشوونما اور فکری ارتقاء اورجسمانی بالیدگی کے ساتھ ابتدائی مراحل طے کرتی ہے۔ بچہ وہی زبان سیکھتا ہے جو اس کے اردگرد بولی جاتی ہے۔ معاشرے کا ہرفرد زبان کو اپنے دائرے اور وسعت عملی کے مطابق استعمال کرتا ہے۔اگر اس کاواسطہ عام لوگوں سے ہے تو اس کی زبان الفاظ بھی ویسے ہی ہوں گے۔اگر وہ کسی مخصوص شعبے سے تعلق رکھتا ہے تو اس کی زبان بھی ویسی ہی ہوگی۔یہ آس پاس کے ماحول پرمنحصر ہوتاہے۔ ادب اور سائنس کے لوگ ہیں ان کی زبان میں فرق ہوگا۔ادبیات سے تعلق رکھنے والے شخص کی زبان مختلف ہوگی۔سائنس کے شعبے سے تعلق رکھنے والے شخص...
This study aims to determine how to determine the contribution of regional taxes and levies to the increase in local revenue at the Regional Revenue Agency of Mamuju Regency. The type of research used in this research is descriptive qualitative. The analytical technique used in this research is to conduct field studies and literature studies. Based on the results of data analysis that has been carried out, it can be concluded that the contribution of local tax revenues has increased in 2013-2014 while in 2015-2017 experienced fluctuating symptoms in each type of tax. Then the contribution of regional levies changes which fluctuate every year in the period 2013-2017. As well as local tax revenues and regional levies contribute to increasing the original revenue of the Mamuju Regency.
The research work was carried out for the phytochemical and biological studies of Conocarpus lancifolius (Combretaceae). Collected plant material was subjected for preliminary phytochemical screening and revealed the presence of cardiac glycosides, saponins, flavonoids, and tannins while alkaloids were absent. Dichloromethane and methanol extracts were prepared and screened for antibacterial activity, antifungal activity, brine-shrimp toxicity, phytotoxicity, antioxidant activity, α-chymotrypsin inhibitory activity, urease inhibitory activity, α-glucosidase inhibitory activity and butyrylcholinesterase inhibitory activity. Dichloromethane extract of Conocarpus lancifolius exhibited moderate antioxidant activity with a percentage inhibition of 42.06±0.64 mg/ml, while the percentage inhibition of methanol extract by DPPH method was 92.1± 0.1 with 396.205 IC50 value, percentage inhibition by nitric oxide scavenging activity was 93.35± 0.61 and percentage inhibition by ferric reducing antioxidant power method was 93.2± 1.02. Dichloromethane extract of Conocarpus lancifolius showed significant α- chymotrypsin inhibition activity with percentage inhibition of 92.20 ± 1.82 and 91.17 ± 0.82 μg/ml IC50 value. Both the extracts of Conocarpus lancifolius exhibited significant lipoxygenase inhibition activity with percentage inhibition of 65.97 ± 0.55 and 63.89 ± 0.02 with IC50 value 158.61 ± 0.08 and 186.31±0.04 respectively. Methanol extract of Conocarpus lancifolius showed significant acetylcholinesterase inhibition activity with percentage inhibition of 87.48 ± 0.09 with 71.21 ± 0.11 IC50 value. Dichloromethane and methanol extracts of Conocarpus lancifolius have promising butyrylcholinesterase inhibition activity with percentage inhibition of 89.52±0.39 at 0.5 mg/ml and 89.06±0.89 with IC50 values 55.25±0.07 and 52.31± 0.11 respectively. Methanol extract of Conocarpus lancifolius was found toxic with LD50 value of 115.76 (0.0048 - 13.76) μg/ml against Artemia salina. Methanol extract of Conocarpus lancifolius exhibited a significant antiurease activity having percentage inhibition value 81.1±1.82 with 49.1± 1.31 IC50 value. Dichloromethane extract of Conocarpus lancifolius showed carbonic anhydrase inhibition activity with 56.7 2.44 IC50 values using acetazolamide as standard. The aqueous ethanol extracts of Conocarpus lancifolius relaxed the spontaneous contractions in isolated rabbit jejunum preparations in dose dependant manner at 0.01- 3 mg/ml tissue bath concentrations. However aqueous ethanol extract of Conocarpus lancifolius relaxed K+ (80 mM) induced contractions in isolated rabbit jejunum 3 preparation and also relaxed carbachol (1μM) induced contraction in isolated rabbit tracheal preparations in dose dependant manner (0.1-3 mg/ml). It is to be reported that the observed response is likely to be mediated through either anti muscuranic activity or/ and blockade of voltage dependant Ca+2 channels. The aqueous ethanol extract of roots of Conocarpus lancifolius have shown a significant relaxant effect in isolated rabbit jejunum preparations with an EC50 value of 0.2075 mg/ml (95% CI: 0.0478- 0.9007). Methanol extract of Conocarpus lancifolius showed a significant α-glucosidase inhibitory activity with an inhibition (%) value of 79.56 and 5.59±0.06μg/ml IC50 value at even very low concentration of 0.0039 mg/ml. Acarbose which exhibit 92.23 % inhibition and 38.25 μg/ml IC50 value was used as standard. On the basis of in vitro α-glucosidase inhibitory activity in vivo study was also carried out on rabbits. Methanol extract of Conocarpus lancifolius significantly decreases the blood glucose level in alloxan induced diabetic rabbits. The pharmaceutical industry is facing serious challenges for drug discovery process. The available drugs for various diseases are extremely expensive, riskier, and critically inefficient. Keeping in view these facts isolation of compounds from dichloromethane and methanol extracts was carried out and seven compounds Quercetin 3-O-glucuronide (A), S-4-isopropyl-8-methoxy-6-thia-bicyclo[3.2.1]oct-1- en-2-yl benzothioate (B), 2,3,4,8,9,10,11,13-octahydro-1H-phenanthro[3,2-c]oxocin- 3-yl benzoatem (C), 1,3,4,5,6,8-hexahydroxy-3,4,5,5a-tetrahydro-1H-benzo[g] isochromene-5-carboxylic acid (D),1-amino-1,5,7,8-tetramethoxy-1Hcyclopenta[ a]naphthalene-2-carboxamide (E), 2,3,8 tri-O-methyl ellagic acid (F), 3- O-methyl ellagic acid 4-O- β -D glucopyranoside (G) were isolated. The chemical structures of isolated compounds (A-G) were established with the help of spectroscopic techniques such as ultraviolet-visible, infrared, proton nuclear magnetic resonance (1H-NMR), 13C NMR (BB, DEPT-135, 90), two dimensional correlation techniques (COSY, HSQC) and mass spectrometry. All compounds were isolated first time from genus conocarpus. The compounds S-4- isopropyl-8-methoxy-6-thia-bicyclo[3.2.1]oct-1-en-2-yl benzothioate (B), 2,3,4,8,9,10,11,13-octahydro-1H-phenanthro[3,2-c]oxocin-3-yl benzoate (C) and 1-amino-1,5,7,8-tetramethoxy-1H-cyclopenta[a]naphthalene-2-carboxamide (E) not only isolated for the first time from genus conocarpus but have noval structures. The S-4-isopropyl-8-methoxy-6-thia-bicyclo[3.2.1]oct-1-en-2-yl benzothioate compound 4 (B) was subjected to antimicrobial activity test against the clinical microbes to determine its biological activities. The zone of inhibition was observed to be between 20 to 24 mm with Bacillus Subtilis having the largest zone of inhibition of 24 ml. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) was determined. It was found that the MFC was higher than that of standard drug Fluconazole. All compounds were screened for antioxidant, in vitro α- glucosidase inhibitory activity, acetylchohline esterase inhibitory activity, and butyl cholinesterase and urease inhibitory activity. F and G compound showed antioxidant activity which is significant when calculated by DPPH method having percentage inhibition of 83.68±0.18 and 68.43±0.17 at 0.5 mM. A, B, C, D and E compounds represented a moderate antioxidant activity by DPPH method having percentage inhibition 42.14±0.13, 16.23±0.15, 16.55±0.13, 17.15±0.16 and 13.36±0.17. Acetylchohline esterase inhibitory activity of compound C and D has significant values 71.62±0.16 and 65.91±0.17. Compounds A-G has exhibited a little percentage inhibition activity of butyl cholinesterase. C, F and G compounds have significant α- glucosidase inhibition with percentage inhibition of 92.83±0.18, 72.26±0.18 and 92.58±0.2. B compound showed a little percentage inhibition of 64.25±0.24. A, D and E compounds have little activity with percent inhibitory values of 17.74±0.17, 42.24±0.16 and 32.64±0.14. Acarbose was taken as standard drug. G compound has shown significant urease inhibitory activity with percentage inhibition 66.54±0.26. A, B, C, D, E and F compounds have little percentage inhibition of 45.91±0.15, 48.85±0.16, 39.75±0.14, 35.96±0.15, 38.64±0.12 and 40.79±0.14m respectively.