مجید احمد تاثیرؔ (۱۹۱۲ء۔۱۹۸۶ء) کا اصل نام مجید احمد اورتاثیرؔ تخلص کرتے تھے۔ آپ سیالکوٹ میں پیدا ہوئے ۔ میٹرک مادرِ علمی علامہ اقبال سے پاس کیا۔ ۱۹۳۳ء میں امر تسر کے ایم اے اوکالج کے طالب علم بھی رہے۔ جہاں ان دنوں ڈاکٹر رشید جہاں اور میاں ڈاکٹر محمود الظفر اُستاد تھے۔ مجید تاثیرؔ امر تسر کی ادبی محفلوں میں شعر و شاعری کرتے رہے۔ فیضؔسے ان کے پرانے تعلقات تھے۔طب کی تعلیم کے لیے تاثیر طبیہ کالج دہلی چلے گئے۔ اس زمانے میں نظم کی طرف توجہ ہوئی اور جوش ملیح آبادی سے دوستی ہوئی۔سیالکوٹ میں تاثیر نے بڑے بڑے مشاعرے کروائے۔ جن میں جوشؔ اور جگرؔ جیسے شاعروں کو مدعو کیا گیا۔(۵۸۴)
لاہور آکر تاثیر نے کچھ عرصہ ملازمت بھی کی۔ آپ نے انار کلی میں ہمدرد مطب قائم کیا۔ جو ش ملیح آبادی جب بھی لاہور آتے تھے ان کے ہمراہ جو چند اصحاب موجود رہتے تھے۔ ان میں تاثیر بھی تھے جوش صاحب مجید تاثیر کی رباعیات کی بہت زیادہ تعریف کرتے تھے۔(۵۸۵)
اُن کا شعری مجموعہ ’’رباعیات تاثیر‘‘ الوقار پبلی کیشنز لاہور نے ۲۰۰۰ء میں شائعکیا۔ یہ مجموعہ کلام رباعیات ،رومانی نظموں اور غزلیات پر مشتمل ہے۔ اس مجموعے کے دو سو سات صفحات ہیں۔اس کتاب کے آغا ز میں ڈاکٹر وحید قریشی نے ’’پیشِ لفظ‘‘ احمد ندیم قاسمی نے تعارف’’مجید احمد تاثیر‘‘ ناہید سلمیٰ نے مضمون’’ تجھے اے زندگی لاؤں کہاں سے‘‘ ڈاکٹر سید عبداﷲ نے تعارف کتاب’’رباعیاتِ تاثیر ‘‘ ڈاکٹر عبادت بریلوی نے تعارف’’رباعیاتِ تاثیر‘‘ اور جوش ملیح آبادی نے ’’تعارف مجید تاثیر ‘‘پیش کیا ہے۔ جوش نے تاثیرؔ کے تعارف کے ساتھ ایک رباعی بھی لکھی ہے۔ جو درج ذیل ہے:
چرخ شعر و ادب کے تارے تم ہو
;جوئے قند و شکر کے...
Everyone knows that ‘hope’ or ‘expectation’ has a pivotal role in the life of a human being. It is a virtue that may produce boost in an individual’s life. All revealed religions urge to their followers to please the Almighty God, and in return they should keep hope from Allah Almighty that He would compensate and reward then in the life thereafter. It is also a matter of fact that there are various aspects of importance of hope in the life of a Muslim. These aspects are discussed in this article in detail. In today’s word, when there are hopeless attitude is found everywhere, this article would present a very positive impact on the society. The article under discussion aims at different aspects of Al- Raja’a (Hope) in the life of a Muslim and its importance for having blessings of ALLAH Almighty. Main ingredients are as follow: · Wideness of blessings of ALLAH Almighty and forgiveness by Him if a person believes in Him and has full commitment on Him. · Self-accountability of a person and his regrets upon his wrong doings and to endeavor adoption of a Right Path. · This belief of Hope pleases one’s self and it brings happiness apparently and inside of this person. · Islam does completely prohibit false beliefs and halfhearted weak faith. In the same way Islam also condemns despondency.
The choice of an analytical method is usually governed by the intrinsic analytical properties of the drug molecule or its amenability to chemical derivatisation to render it compatible to quantitation. The reliability of the quantitation depends on these analytical techniques. Currently, reversed phase high–performance liquid chromatography with UV detection represents the analytical method of choice for the quantitative determination of raw material, in-processes formulation, finished products as well as in the biological matrix. Metronidazole is one of the most effective and clinically very useful and popular antibacterial agent which also possess antiprotozoal action. The clinical importance of these agent is continuously increasing with the passage of time, as the infections are caused by the different pathogens/microorganisms. In the proposed study first developed the analytical method for the determination of metronidazole then validate it for the evaluation of pharmaceutical property of different brands of metronidazole 200mg and 400mg available in the local market as per ICH guideline. The parameters that used for the validation were specificity, linearity, accuracy, precision, lower limit of detection, quantitation and stability of drug in mobile phase as well as in biological matrix. The mobile phase was comprised of 0.01 molar potassium dihydrogen phosphate buffered at pH 3.0 and acetonitrile in ratio of 83: 17. The drug was eluted from C18 column (5µm; 250 mm X 4.6 mm). The % RSD of peak areas of metronidazole was 0.03% and the mean retention time of six consecutive injections was 5.333 minutes. The LOD and LOQ of the method was 8.14ng/mL and 32.56ng/mL respectively. The drug was stable in mobile phase as well as in plasma up to 28 days that shows the method can be used successfully not only for the raw material and finished product but also for pharmacokinetic study in human. A new formulation (ODT) was developed with the use of different super disintegrants such as sodium bicarbonate and crospovidone. Comparison of disintegration and friability of the tablets showed that the tablet with crospovidone is more close to our objective. The optimization study was performed with the aid of software “DesignExpert 9.0.1, State Ease Inc.” The amount of crospovidone and HPMC per batch were taken as independent variable to assess their effect on the disintegration time and friability of the formulation. Central composite design was selected for optimization process and number of batches were prepared. The amount of X1 (Crospovidone) and X2 (HPMC) predicted by the software with the desirability of 1.0 were 37.76mg and 16.71mg respectively. A check point batch were prepared based on these predicted amounts to confirm the validity of the design for this optimization process. The results revealed that by increasing the concentration of crospovidone in formulation decreases disintegration time of tablets which is quite expected as it enhances the wicking property of the formulation. Similarly, it was also observed that increase in concentration of HPMC significantly decreases the % friability of the tablets as it improves the cohesive binding forces. The check point batch was subjected to stability studies after blistering for 06 months. All the tests performed as per USP for the physicochemical and stability evaluation periodically at time interval of 3 months and 6 months. The results were then compared with the initial results to evaluate the stability characteristics of the formulation. The results showed no significant differences at time intervals of 0, 3 and 6 months. Hence the formulation found to be well stable under the recommended conditions (temperature: 40 ± 2°C & % RH: 75 ± 5%). The friability was between 0.47% - 0.50%, disintegration time was between 15 – 16 seconds and in vitro dissolution at three different time intervals i.e. 0, 3 and 6 months were between 98.08 - 98.29% during the entire period of stability studies. No significant variation observed in content assay of stability batch throughout the study period. The CDP of metronidazole 200mg, 400mg brands and formulated tablets were performed in three dissolution mediums i.e. pH 1.2 buffer, pH 4.5 buffer & pH 6.8 buffer. The samples were withdrawn at different time intervals i.e. at 10, 15, 20 and 30 minutes and absorbance was taken at λmax 278.0 nm. Percent dissolution calculated with the help of Microsoft excel add-in “DD Solver” v1.0 found to be ≥ 85% within 15 minutes which indicates that dissolution is not a rate limiting step in the bioavailability of these tablets. Different dissolution models were also applied to verify the drug release pattern between the marketed and formulated drug and it was found that the pattern release of the formulated tablets is same as that of the marketed and innovator brands