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Home > Drug Induced Developmental Defects of Teeth

Drug Induced Developmental Defects of Teeth

Thesis Info

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Author

Nazir, Shakila

Program

PhD

Institute

Baqai Medical University

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Natural Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/388

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725926842

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The present study was designed to evaluate the effect of commonly used drugs on the dental tissues. The dental tissues are sensitive to certain drugs if they are used by the conceiving mothers for a prolonged period of time during pregnancy. Some commonly used drugs were selected for this study e.g. aspirin, estrogen and lithium, which have been reported to affect the human tissues in intrauterine life, if used by the mothers. The study was conducted on the female rabbits. The experimental animals were divided into four groups, each of which having (n=7) subjects. Three of them for the study of drug treatments and the fourth one was taken as a control. Drugs were given with the predetermined doses according to their body weights, until the birth of their offsprings. The offsprings of these rabbits were used for the research purposes. Different parameters e.g. the variation in the size of the teeth, the contents and composition of mineral in the outer dental tissue i.e. enamel, and the ultrastructural changes of the enamel surfaces of teeth, investigated by SEM were included in the study. Analysis of teeth was done at the age of three months to examine the congenital defects developed during intrauterine life. Volumetric analysis was done on 672 samples before the extraction of teeth. The teeth were then extracted to analyze 336 samples for the mineral contents and to study the surface structure of enamel with the help of scanning electron microscope and energy dispersive X-ray spectroscopy (SEM-EDX). A very large variation was observed in the results, within the samples, between the control and the experimental groups, from either the chemical analysis or the volumetric measurements. It was observed that the incisors and molars were esthetically and functionally the compromised teeth. It was apparent that the statistically significant results could not be achieved which have overshadowed the aggregate differences between the groups. However this study could help to establish the association of chronic use of certain drugs with the developmental anomalies of dental tissues. It may also guide the future investigators to work on the interaction of drug related factors in pathogenesis of different pathologies. It could possibly be helpful to achieve the aesthetic and functional goals in the field of dentistry. The study was expected to provide suggestions for the use of certain drugs during pregnancy and new leads for further research.
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ستاروں سے آگے جہاں اور بھی ہیں

ستاروں سے آگے جہاں اور بھی ہیں
نحمدہ ونصلی علی رسولہ الکریم امّا بعد فاعوذ بااللہ من الشیطن الرجیم
بسم اللہ الرحمن الرحیم
معزز اسا تذہ کرام اور میرے ہم مکتب شاہینو!
آج مجھے جس موضوع پر اظہار خیال کرناہے وہ ہے: ’’ستاروں سے آگے جہاں اور بھی ہیں‘‘
جنابِ صدر!
شاعراس شعر میں ہماری توجہ جہد مسلسل کی طرف دلانا چاہتا ہے، وہ کاہلی، سستی اور تساہل کے قعرِ ذلت میں گرنے سے بچاتا ہے ،وہ یہ یاد کرانا چاہتا ہے کہ حرکت میں برکت ہے اور ہمیشہ کی کدو کاوش سے انسان بالآ خرمنزل پرپہنچ جاتا ہے۔
صدرِمحترم!
زندگی حرکت کا نام ہے۔ حیات کے لمحات متحرک رہنے والے کے ہوتے ہیں،لمحات زیست کی چاشنی جمود کا شکار افراد کے لیے سمِ قاتل ہے۔ زندگی کی رنگینیاں، زندگی کی رعنائیاں اسی کوملتی ہیں جو ان کے حصول کے لیے جسمانی اور فکری قویٰ منظر عام پرلاتا ہے اس طرح وہ نہ صرف ستاروں کو دیکھتا ہے بلکہ ستاروں پر کمندیں بھی ڈال لیتا ہے اور کامرانی اس کے قدم چوم لیتی ہے۔
جنابِ صدر!
انسان اگر آگے بڑھنے کا جذبہ بیدار رکھے گا، تو آسانیاں میسر آتی جائیں گی، مشکلیں حل ہوتی جائیں گی ، پریشانیوں کا وجود عنقا ہو جائے گا ، مشکلات، سہولیات میں بدل جائیں گی ، الجھنیں کافور ہو جائیں گی ، خوشیوں اور مسرتوںکے گلستانوں میں بہار آجائے گی۔
صدرِ محترم!
جمود انسان کے لیے سم قاتل ہے، جمود اشیاء خوردنی میں آجائے تو انہیں متعفن کر کے رکھ دیتا ہے۔ اعضائے جسمانی میں آجائے تو انہیں شل کر کے رکھ دیتا ہے علم و دانش میں آجائے تو فصاحت، جہالت کے قریب ہو جاتی ہے۔ جمودمطالعہ میں آجائے توصاحب علم کی میز گردآلود ہو جاتی ہے۔
صدرِمحترم!
انسان کی ترقی کا راز...

The Incident of September 11 (2001) & its Socio Political Implications on Pakistan

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Pakistans Cotton and Textiles Exports to the European Union: Competition, Trade Barriers, Future Prospects and Outlook

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In case of the individual major categories (26, 65 & 84), the following 5-digit products, being the EU’s most preferred products, should be given priority, in particular. (a) The eight Pakistani 5-digit 26-category products (SITC codes: 26339, 26310, 26902, 26490, 26721, 26901, 26652 and 26711) have attained positions in EU’s first 20 preferred products list, while remaining 12 the EU’s preferred products (Table 4.30a) have fallen into Pakistan’s relatively less preferred products list; Pakistan should improve the quality of these products to attain better position in the EU’s 5-digit 26-category market. (b) In case of 217 5-digit 65-category products, only 14 Pakistani products (65843, 65841, 65842, 65221, 65847, 65234, 65133, 65243, 65851, 65232, 65242, 65184, 65892, and 65859) have got positions in the EU’s first 50 preferred products list; the remaining 36 the EU’s first category preferred products (Table 4.31a) should now be having attention of Pakistani stakeholders. 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