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Effect of Colchicine on Cellular and Humoral Immune Responses in Mice

Thesis Info

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Author

Syed, Shahzada Khurram.

Program

PhD

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Subject

Pharmacology

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/9381/1/Shahzada_Khurram_Syed_Pharmacology_%26-Toxicology_HSR_UVAS_2016_12.04.2017.rar

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725957261

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Colchicine is separated from Colchicum autumnale plant (Battersby et al.1972).Colchicine was approved in 2009 by the Federal drug agency (FDA) for the prophylaxis and the treatment of acute attack of gout (Richette and Bardin 2010). It is investigated that colchicine reduced pain of gouty arthritis (Lidar and Livneh 2007). Colchicine ointment is useful for treatment and prevention of acute gout attacks (Maduri and Atla 2012).Colchicine is an alkaloid. It is used for the treatment of Familial Mediterranean fever and gout. It has played its anti-inflammatory role by acting on microtubules. Molecular basis of this drug has studied on expression of human umbilical vein endothelial cell line gene. It has ability to change expression of gene which resulted in inflammatory processes or neutrophil migration. This drug not only have anti-inflammatory role through inhibition of microtubules but also changes at transcriptional level of gene expression (Chetrit et al. 2006). Colchicine has been used for the treatment of biliary and liver cirrhosis (Sabouraud et al. 1992).Colchicine is beneficial for the treatment of idiopathic thrombocytopenic pupura resistant to regular treatment (Strother et al. 1984).
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زندگی خدا کی نعمت ہے

زندگی خدا کی نعمت ہے
اس کائنات رنگ و بو میں جہاں نظر دوڑائیں اُس منعم حقیقی کی عطا کردہ نعمتوں کی فراوانی ہی فراوانی ہے۔ کہیں کھیت وکھلیان کشت ِزعفران کا نمونہ پیش کر رہے ہیں، کہیں گلستان و نخلستان جشنِ بہاراں کی آمد کی نوید جانفراسُنارہے ہیں ، کہیں دریا اور نہر یں جوئے نغمہ خواں کی صورت میں موجود ہیں، کہیں کوہستانی علاقوں میں موجود فلک بوس پہاڑ اور جبال شامخہ ناظرین کو ورطۂ حیرت میں ڈال رہے ہیں۔ یہ سب اللہ تعالیٰ کی نعمتیں ہیں جو مختلف شکلوں میں موجود ہیں۔ لیکن ان سب سے بڑھ کر جواللہ تعالیٰ کی عظیم نعمت ہے وہ زیست ہے، وہ حیات ہے، وہ زندگی ہے۔
زندگی ہے تو سب نعمتیں رعنائیاں بکھیرتی ہوئی نظر آتی ہیں، زندگی کے حیات بخش قطروں سے سیراب شخص ہی جملہ انعاماتِ ربّانی سے متمتع ہوسکتا ہے، زندہ شخص ہی بادِنسیم کے مسحور کن جھونکوں سے مسرور ہوسکتا ہے، زندگی ہی گلہائے گلستان ونخلستان کی حسن و زیبائش کا احساس دلاسکتی ہے، زندگی سے حرکت ہے، زندگی سے برکت ہے، زندگی سے عبادت ہے، زندگی سے عیادت ہے۔ انسان کا وجود، قوم کا وجود ، معاشرے کا وجود ملک و ملت کا وجود زندگی کا ہی مرہونِ منت ہے۔
زندگی کی حقیقی رعنائیوں سے فائدہ اٹھانے والے ذی فہم فراست لوگ آسمان علم و دانش پر آفتاب و ماہتاب بن کر چمکتے ہیں، وہ اس حقیقت کو بھی فراموش نہیں کرتے کہ یہ زندگی ہمارے پاس اللہ تعالیٰ کی دی ہوئی امانت ہے، ہم نے اس میں خیانت نہیں کرنی ہے، ہم نے اپنی زندگی کو اُسی راستے پر گامزن کرنا ہے جہاں خالق حقیقی کی منشاء و مراد ہے۔
قرآنِ پاک میں ارشادِ باری تعالیٰ ہے کہ ’’ ہم نے انسان کو اور جن کو صرف اس لیے پیدا کیا...

Jenkins' Deliberations on Communal Conflict with the Leaders of Punjab: 1946-47 (Part-I)

Bhim Sen Sacher informed Jenkins about the destruction caused by arson in Lahore. Akbari Mandi, Chune Mandi, Chauhatta Basti, Bhagat Singh Basti, Kucha Kagzian and Pipal Vehra had been burnt down. The fire brigade could not cope with those vast and dispersed areas. If someone tried to extinguish the fire he was shot at by the police. Bhim Sen Sachar suggested that the only way to save Lahore was to impose martial law in the city. He hoped that the Governor would take that step immediately.64 Jenkins thanked Lala Bhim Sen Sachar and Gokul for their letters informing him about Lahore. Jenkins explained that fire brigade had done a good job in spite of constraints and difficulties. He believed that all communities had access to incendiary materials, and could use it without detection by traversing joined roof-tops. Throwing fire-balls from one house to another was wreaking devastation. Checking trouble of that kind was not an easy job, but searches were carried out and culprits were arrested.6

Atmospheric Pressure Microplasma Assisted Synthesis of Metal and Metal Oxide Nanostructures and Their Application

Transition metals and metal oxide nanostructures are promising materials owing to their unique physical and chemical properties such as thermal stability, rigidity, and high chemical resistance. These properties enable them to be utilized for a wide range of environmental and biological applications; including antibacterial and photocatalytic activities etc. This led various research groups to develop several techniques for the synthesis of metal nanomaterials with different sizes, shapes and morphologies. However, it is still desirable to develop new environment-friendly synthetic processes to prepare these nanomaterials with new textural forms for their viable applications. In this regard, a very simple, fast, cost-effective and toxic free self-designed Atmospheric Pressure Microplasma (AMP) technique has been developed for the synthesis of metals (Ag and Au) and metal oxides (ZnO and CuO) nanostructures. In addition, several analytical techniques were used to study the morphological, structural, optical and compositional properties of the synthesized nanostructures. Furthermore, the prepared noble metal (Au and Ag) nanostructures were used for antibacterial applications while the metal oxide (ZnO and CuO) nanostructures were used for both antibacterial and photocatalytic applications. Scanning electron microscopy (SEM) showed the sheet-like structures of Ag and spherical structures for Au. However, a change in lateral dimension has been observed with the increase in the precursor’s concentration. XRD showed highly crystalline nature and single phase (fcc symmetry) of the as-synthesized Ag and Au nanostructures. In addition, highly crystalline ZnO nanostructures (nanosheets, nanodrums, and nanoneedles) were synthesized in the presence of different ionic (anionic and cationic) surfactants and nonionic fructose. It was found that the fructose and surfactants greatly influenced the morphology of synthesized ZnO nanostructures. Similarly, highly crystalline sheet-like CuO nanostructures were also synthesized without using any surfactant. SEM of CuO confirmed the variation in the dimensions of nanostructures with precursor’s concentration. XRD showed the hexagonal (wurtzite structure) phase of ZnO and monoclinic phase of CuO. The antibacterial tests of all the synthesized nanomaterials were evaluated against several bacterial strains. Results suggested that all the nanostructures exhibited effective bactericidal activity against all tested strains. It was observed that the antibacterial activity of the prepared samples not only depends upon the shape of nanostructures, but also on the type of the bacteria. This study also demonstrates the photocatalytic activity of the assynthesized ZnO and CuO samples for the degradation of organic dyes under direct sunlight. Results indicated that the ZnO and CuO sheet-like photocatalysts exhibited significant photocatalytic activities against tested dyes after 80 minutes of sunlight illumination. The findings of this research work may prove helpful in contributing towards new studies conducted on applications involving catalysis, optoelectronic devices, biomedical, pharmaceutical, environmental bioremediation and so forth.