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Effect of High Protein Diet on Pancreatic B-Cell Regeneration & Funtioning in Diabetic Rats

Thesis Info

Access Option

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Author

Muzaffar, Humaira

Program

PhD

Institute

University of Agriculture

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Biological & Medical Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10862/1/Humaira%20Muzaffar_Physiology_2019_UAF_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725971395

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Diet is a key factor in fulfilling energy requirements, maintaining metabolic homeostasis and promoting health. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from defective insulin production or secretion from pancreatic β-cells, insulin function or both. The type, amount as well as balance of main macronutrients (proteins, fats and carbohydrates) present in diet are of particular significance in managing the diabetes. However, relatively little is known about the underlying molecular mechanism that how protein rich diet is responsible for functional changes in pancreatic β-cells. Current study was intended to evaluate the effect of high protein diet on body weight, glycaemic control, regeneration of β-cell, production and release of insulin in diabetic rats. High protein diet (45% and 55% fish protein) was administered in alloxan induced diabetic rat model for a period of 28 days. Blood samples were collected for monitoring blood glucose level, lipid profile and other biochemical parameters. Pancreatic tissue samples were collected for histopathological study. The data was subjected to statistical analysis by applying one way ANOVA and DMR. Results revealed that protein rich diet counteracted the reactive oxygen species (ROS) and normalized the elevated levels of blood glucose (198.1±11.5), cholesterol (64.73±2.24) and triglycerides (65.97±4.62) compared to positive control group having serum glucose (606.8±12.3), cholesterol (95.36±4.6) and triglycerides (109.5±3.51) respectively. Histopathological analysis revealed that high protein diet helps in normal regeneration or replenishing of β-cells. The role of calcium and cellular stress pathways are important in underlying mechanism behind the ROS production and its control as low expression levels of Calm-2, Grk-2, Pias-2, Traf-4, Traf-6 and MAPK-8 genes were observed in high protein diet treated groups in comparison to positive control. High protein diet also improved β-cell function and performance by up regulating the expression of INS-1, INS-2 & Pdx-1 genes. In conclusion, results indicated the regenerative and protective potential of high protein diet in alloxan-induced diabetic rat model.
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(ب)سیالکوٹ میں اردو نثر مابعد قیام پاکستان

باب چہارم

خطۂ سیالکوٹ ۔ تنقید

(الف) اقبال شناسی

          ڈاکٹر خواجہ عبدالحمید عرفانی (۱۹۰۷ء۔۱۹۹۰ء) کا اقبال شناسوں میں اہم مقام و مرتبہ ہے نہ صرف سیالکوٹ میں بلکہ عالمی سطح پر اقبال شناسی کی روایت میں خواجہ عرفانی ایک اہم نام ہے۔ اقبال کو ایران میں متعارف کرانے کا سہرا خواجہ عرفانی کے سر جاتا ہے۔ عرفانی صاحب کی ادبی خدمات بے پایاں ہیں مگر ہمیں یہاں صرف عبدالحمید عرفانی کی اقبال شناسی کا جائزہ لینا ہے۔ اقبال کو ایران میں متعارف کرانے کے لیے ’’رومی عصر‘‘ جیسی مدلل کتاب، پاکستان میں جنم لینے والی مشہور عشقیہ داستانوں کو ’’داستان پائے عشق پاکستان‘‘ کے نام سے ایرانیوں کے لیے ’’ضربِ کلیم‘‘ کا فارسی ترجمہ لکھنا اور عبدالحمید عرفانی کی بے پایاں محنت اور اقبال سے محبت کی غماز ہیں۔ خواجہ عبدالحمید عرفانی نے علامہ اقبال پر ’’اقبال ایرانیوں کی نظر میں‘‘ ،’’اقبالِ ایران‘‘ اور ’’پیامِ اقبال‘‘تین کتابیں لکھی ہیں۔

           ’’اقبال ایرانیوں کی نظر میں ‘‘ میں یہ واضح کرنے کی کوشش کی گئی ہے کہ اقبال سے آشنا ہونے کے بعد اہلِ علم ایرانیوں کی اقبال کے بارے میں رائے اپنے بزرگ شعرا جیسی تھی۔ اور وہ اقبال کو حافظ ،جامی ،سعدی اور رومی کی صف میں شمار کرنے لگے تھے۔ ’’اقبال ایران‘‘ میں عرفانی نے اپنے قیام ایران کے دوران اقبال کو ایران میں متعارف کرانے کی جدوجہد، ایرانیوں کی اقبال سے آشنائی اور ایرانیوں کی اقبال اور پاکستان سے محبت کا اظہار کرنے کا تذکرہ کیا ہے۔ ’’پیامِ اقبال‘‘ میں عرفانی صاحب نے طلبا کی سہولت کے لیے اقبال کے پیغام کا خلاصہ چند صفحات میں پیش کیا ہے۔ اقبال کو ایران میں...

التماسك النصي وعلاقته بالنص القرآني دراسة نظرية في ضوء التراث النقدي والبلاغي

The concept of cohesion is not only a semantics one that exists within the meaning of text; it refers to grammatical relations of the Text The concept of cohesion is not only a semantics one that exists within the meaning of text; it refers to grammatical relations of the Text that exist within surface structure of the text, and that define it as a text. That is why the study of cohesion is important in text linguistics, especially in the Text of holy Qur‘ān.  Therefore the ancient researchers have chosen it in different ways in the Qur‘ānic textual analysis. The ancient Arab started the study of Cohesion to prove the Qur‘ānic text as “Mojza” and “ijaaz” because of its organization and arrangement of text according the “Nazem” “Insijaam” “Ittisaaq” “Iltehaam” and many others. The English term that substitutes these terms is just Cohesion and Coherence. So we can say that the Arab was doing well about the discourse/textual analysis of the texts, especially the Qur‘ānic textual cohesion was their main goal. This research work differ from previous works in many aspects, while  the researcher focuses on the concept of cohesion and its various aspects, particularly in terms of the cohesion and coherence in Arabic Language in the light of Qur‘ānic text. That exist within surface structure of the text, and that define it as a text. That is why the study of cohesion is important in text linguistics, especially in the Text of holy Qur‘ān.  Therefore the ancient researchers have chosen it in different ways in the Qur‘ānic textual analysis. The ancient Arab started the study of Cohesion to prove the Qur‘ānic text as “Mojza” and “ijaaz” because of its organization and arrangement of text according the “Nazem” “Insijaam” “Ittisaaq” “Iltehaam” and many others. The English term that substitutes these terms is just Cohesion and Coherence. So we can say that the Arab was doing well about the discourse/textual analysis of the texts, especially the Qur‘ānic textual cohesion was their main goal. This research work differ from previous works in many aspects, while  the researcher focuses on the concept of cohesion and its various aspects, particularly in terms of the cohesion and coherence in Arabic Language in the light of Qur‘ānic text.

Performance of Media in Pakistan in Creating Awareness About Population As an Economic Problem

Pakistan has become the sixth largest populous country and the third largest contributor of the world. At the time of independence in 1947 it was 14th in rank with a population size of 33.5 million that has explosively grown to 180 million, with annual net growth of 30 million, making population growth the real economic problem. In context of basic most resource of water Pakistan went from surplus in 1950 to relatively abundant in 1980; water stressed by about 2010 and will be water scarcity by 2035. PEDA model analysis, with the variables of Population, Environment, Development and Agriculture has proven population as real economic problem in Pakistan. Pakistani media unfortunately been used to indoctrinate nationalistic ethos like Islamization and protect military rulers, as media was govt owned. Dilemma continued and still going on even in era of private media in the country .as private media is like a pure commercial activity, trying to share power as a political actor and gathering a repute of sensationalism. Genesis of media performance and strength as institution in Pakistan can be traced from its vital role played in the independence of country. Efforts have also been made to study factors of personal and institutional barriers that may hinder the process of bringing change in people’s mindset in favour of having fewer children. The research highlights that though media has the responsibility of representing thoughts and feelings with regard to any social problem and guide people to take steps, the Pakistani media has presented the social problems like population growth but has failed in converting the thoughts and feelings into actions. Data were analysed separately for the two groups of participants. Media experts were interviewed to obtain more in-depth information on the variables of interest. The primary data findings corroborated the results of secondary data findings. The results of the surveys indicate that both the students and media experts think that the media in Pakistan is strong. It has proved its strength time and again. Still, it has never focused on population as a problem. Failure of media performance can be gauged from the fact that a high percentage of media experts, obviously with maximum media exposure, who were interviewed, did not know the rank of Pakistan in the world population and a clear majority did not know the net growth of 30 million in already overpopulated country. Without realizing how big the issue is, they cannot pay the due attention towards this issue.