سلطان کھاروی دی پنجابی نظم نگاری
نظم توں مراد شعراں دا اوہ مجموعہ جیہدے وچ کوئی اک مرکزی خیال ہوندا اے ۔بہت زیادہ شعر ہون پاروں خیال دی درجہ بدرجہ بڑھوتری ظاہر کرن خاطر شعراں نوں وکھ وکھ حصیاں وچ ونڈ لیا جا ندا اے تاں جے نظم دے معنی تے مفہوم واضح ہو سکے ۔نظم وچ اکو خیال نوں سرنانواں بنایا جا ندا اے ۔ایس وچ شعراں دی گنتی دی کوئی حد مقرر نہیں ہو ندی ۔کیول خیال دی ایکتا نوں مکھ رکھیا جاندا اے ۔
ایس لئی سرنانویں دی کوئی پابندی نہیں ۔کسے وی سرنانویں اتے وچاراں دی سانجھ پائی جا سکدی اے ۔بھانویں اوس سر نانویں دا تعلق تاریخ نال ہووے یا ںجغرافیہ نال ،دینی ہووے یاں دنیاوی ،تہذیبی ہووے یاں ثقافتی ،سیاسی ہووے یاں دھرمی،قومی ہووے یاں انقلابی ،نواں ہووے یاں پرانا،علمی ہووے یا ں ادبی ہر پکھ تے دنیا دے ہر معاملے ،حیاتی دے ہر مسئلے تے کائنات دے ہر پکھ بارے نظم لکھی جا سکد ی اے ۔
موضوع وانگ نظم لئی کسے خاص بنتر ڈھنگ دی لوڑ نہیں ۔جیویں نظم لئی کوئی وی سرنانواں چنیا جا سکدا اے ۔ایسے طرح کوئی وی بنتر ڈھنگ اختیار کیتا جا سکدا اے ۔بھانویں روایتی طور تے نظم دیاں کجھ خاص خاص قسماں واسطے کجھ خاص بنتر ڈھنگ موجود نیں پر عام طور تے نظم واسطے کوئی خاص ہئیت مقرر نہیں کیتی گئی ۔ایس لئی جدوں سلطان کھاروی دیاں نظماں دا ویروا کرئیے تاں ساہنوں اوہناں دی شاعری وچ ہر قسم دیاں نظماں مل جاندیاں نیں ۔جس توں گویڑا لایا جا سکدا اے کہ سلطان کھاروی ہوری اُچ پدھر دے نظم گو کوی نیں کیوں جے اوہناں پابندنظماں توں وکھ آ زاد نظما ںتے نکیاں نظماں وی لکھیاں ہن ۔آپ دیاں نظماں دا موضوعاتی ویراوا...
Spending in the cause of Allh is one of the most important ways for the welfare of society and all the divine books agreed about its vital role in the betterment of human lives. But it is obvious from Quraan that not everyone has capacity for it but only those who are saved from stinginess: And whoever is protected from the stinginess of his soul - it is those who will be the successful. (Al-Hashr: 09) It is also very relevant question in this regard that what should be spent? And how and where should be spent? Hence only that type of spending which is according to the need of time is worthy to be called as best use of it, as Prophet (Peace be upon Him) pointed out to the charity of water when Saad ibn e ubadah asked him about the best mean of charity after the death of his mother and people were in urgent need of water. So it is clear that the one who intended to charity must have the actual and original idea about the demand of those who are in crises and then he should decide to arrange the appropriate means in this regard. We found crystal clear indications in the seerat ur rasool (Peace be upon Him) about the appropriate spending in accordance with the demands of current time like the encouraging the release of slaves especially in the Makkah and the treaty of brotherhood among the immigrants and the ansaar and promoting the building of prophetic mosque and preparing the army for battles and promising the abode in paradise in response. This article deals with role of charity in welfare of current society by the proper means and ways, some of the important points are as follows: 1. Introduction. 2. Importance of Infaq in Quraan and Sunnah. 3. Examples of charity in accordance with the demands of society in light of seerah. 4. Charity endowments and its role in the well-being of society in the light of fiqh us seerah. 5. The needs of contemporary society and the role of Charity endowments. 6. Pre-protection from negativity, because prevention is better than cure. 7. Recommendations or proposals for proper expenditure
The research work presented in this thesis deals with the chemotherapeutic (antiproliferative) and cancer chemopreventive activity of a medicinal plant from Pakistan; Fagonia cretica L. (Zygophyllaceae), based on the traditional claims for its use in folklore medicine in the treatment of different types of cancers and inflammatory conditions. Through a bioactivity guided fractionation approach, the crude extract (FCC), resultant two organic fractions i.e. n-hexane and ethyl acetate (FCN and FCE, respectively) and an aqueous fraction (FCA) were tested for their anti-proliferative and cancer chemopreventive activity by employing different standard bioassays. In this investigation, it was demonstrated that F. cretica extract and fractions have antiproliferative activity towards human breast cancer cells and it can exert cancer chemopreventive effects via NFκB inhibition, iNOS inhibition and QR induction. The most potent fraction was ethyl acetate (FCE) fraction followed by n-hexane fraction (FCN) in this study. Six compounds in total (FCEE1, FCEK2, FCEK3, FCEM4, FCEN5 and FCNC6) were isolated from potent fractions of this medicinal plant using repeated flash column chromatography. Structural elucidation was carried out through a series of spectroscopic experiments (1-D and 2-D NMR). Among these six compounds, one compound (FCEE1) is a triterpene acid, two compounds (FCEK2 and FCEN5) belong to the triterpene saponin class, one compound FCEM4 belongs to steroidal saponin class and two compounds (FCEK3 and FCNC6) belong to phytosterol class of chemical compounds. All the isolated compounds have known structures but these are isolated from this plant species for the first time. All the compounds were evaluated for their anti-proliferative activity against breast cancer cell lines (MCF-7 and MDAMB- 231), non-tumorigenic breast epithelial cell line (MCF-10A) and cervical cancer cell line (HeLa) by using sulforhodamine B (SRB) assay. Cancer chemopreventive potential of compounds was also estimated in different bioassays i.e. TNF-α activated nuclear factor-kappa B (NFκB) assay, inhibition of lipopolysaccharide (LPS)- activated nitric oxide (NO) production in murine macrophage RAW 264.7 cells (iNOS) assay, Aromatase inhibition assay and Quinone reductase 1 (QR1) induction assay. A serial dilution of eight concentrations (0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 μM) for each compound was tested. xix Purified compounds were able to reduce cell viability significantly in two phenotypically different breast cancer cell lines (MCF-7 and MDA-MB-231). This activity was markedly reduced in normal mammary epithelial cells (MCF-10A) thus indicating selective toxicity between malignant and normal cells. Among compounds, in NFκB inhibition assay, FCEE1 showed maximum inhibition (IC50, 5.26 μM) while in iNOS inhibition assay, FCEM4 demonstrated best activity (IC50, 0.38 μM). For QR1 induction, FCNC6 was proved to be best compound (CD, 17.07 μM). None of the compounds were active in inhibiting aromatase enzyme. Compound FCEE1, a triterpene acid was the most potent compound in this study followed by FCEM4. Elucidation and characterization of the cytotoxic mechanism was undertaken by cell cycle status, apoptosis and expression of transcription factors and their targets i.e. p53, p21, Bax, γ-H2AX and FOXO3a. Pure compound treatment was able to induce a time and dose-dependent decrease on cell viability of two phenotypically different breast cancer cell lines (MCF-7 and MDA-MB-231), while demonstrating a markedly decreased cytotoxic effect of triterpene acid (FCEE1) and derivatives i.e. triterpene saponins (FCEK2 and FCEN5) on normal mammary epithelial cells (MCF-10A). Cell cycle arrest (expressed by sub-G1 peak) and apoptosis was induced in both MCF-7 and MDA-MB-231 cells. Overall all the purified compounds were more effective against estrogen receptor negative breast cancer (MDA-MB-231) cells. Loss of breast cancer cell viability is associated with induction of DNA double strand breaks which were detected in both cell lines by pure compounds’ treatment. In MCF-7 cells, expression of p53 by FCEE1 seems to induce upregulation of the CDK inhibitor, p21, and pro-apoptotic Bax. In current study, pure compounds’ treatment to human breast cancer cells induced double strand breaks to DNA associated with activation of DNA repair protein γ-H2AX. Compound FCEM4 treatment was able to induce FOXO3a expression in both MCF-7 and MDA-MB-231 cells. This suggests that activation of FOXO3a in the absence of functional p53 plays a vital role in induction of cytotoxicity. The results of this study suggest that FCEE1 is cytotoxic through p53 dependent as well as independent pathways while FCEM4 uses only p53 independent pathway.