Cardiovascular Effects of Nigella Sativa on Isolated Rabbit Heart and its Impact on Cardiac Remodeling

Background: Black Cumin/Nigella sativa (NS) which belongs to the botanical family of Ranunculaceae commonly grows in Eastern Europe, the Middle East, and Western Asia. Its prolonged use can produce physiological changes with or without affecting the architecture of different organs like the heart (cardiac remodeling). The data for the cardiovascular benefits of black cumin are not well-established scientifically. Objectives: To determine the direct cardiovascular effects of Nigella Sativa extract on heart rate, cardiac contractility (apical force), ECG, and coronary flow in the normal heart with and without cardiac remodeling. Methods: This experimental study was conducted on forty-two (42) rabbits. These rabbits were divided into seven groups, each comprising six animals (Group I-VI without cardiac remodeling and Group VII with cardiac remodeling). NS was given to these groups in different doses i.e, Group I (NS=10ug), Group II (NS=30ug), Group III (NS=100ug), Group IV (NS=300ug), Group V (NS=3000ug), Group VI (NS=10000ug) and VII (NS=300ug). Radnoti's working heart system was used to determine the effects of NS on heart rate, cardiac contractility (apical Force), ECG, and coronary flow in a normal heart with and without cardiac remodeling. The results were analyzed using SPSS version 28.   Results: Results of this study revealed negative chronotropic and positive inotropic effects without ECG changes in the normal heart and with ECG changes in the remodeled heart. Conclusions: Prolonged use of Nigella sativa can lead to disturbed ECG by affecting the conducting tissue.

Comparative Effectiveness of Expository Strategy and Problem Solving Approach of Teaching Mathematics at Secondary Level

A sound education in mathematics is important for any modern knowledge based economy. Mathematics is now important in many areas where it has not previously played much of role, for example, in biology, social sciences etc. If the proper mathematical foundations are not laid during the formative years of childhood and adolescence, it becomes increasingly difficult to address this weakness in later life. The attempts to confront these shortcomings during retraining in later life are generally wasteful and only partly successful. The present study was designed to investigate the comparative effectiveness of problem-solving approach on the academic achievement of secondary school students in mathematics. The major objectives of the study were: (1) To determine whether the problem solving approach is more effective than expository strategy of teaching on academic achievement of students in mathematics. (2) To determine whether the problem solving approach is more effective than expository strategy of teaching on attitude of students in mathematics. (3) To examine the effect of problem-solving approach on the academic achievement of low achievers. (4) To measure the effect of problem-solving approach on the academic achievement of high achievers. (5) To find out the effect of problem-solving approach on the retention of students in mathematics. To achieve the objectives of study, following null hypotheses were tested: (1) There is no significant difference between the pre-test mean achievement scores of experimental and control group. (2) There is no significant difference between the pre-test mean achievement scores of low achievers of experimental group and control group. (3) There is no significant difference between the Pre-test mean achievement scores of high achievers of experimental and control group. (4) There is no significant difference between pre-test mean attitude scores of experimental group and control group. (5) There is no significant difference between the post-test mean achievement scores of experimental group and control group. (6) There is no significant difference between post-test mean achievement scores of low achievers of experimental group and control group. (7) There is no significant difference between post-test mean achievement scores of high achievers of experimental group and control group. (8) There is no significant difference between post-test mean attitude scores of experimental group and control group. (9) There is no significant difference between mean achievement scores of experimental group and control group and control group on retention test. (10) There is no significant difference between mean achievement scores of high achievers of experimental group and control group on retention test. (11) There is no significant difference between mean achievement scores of low achievers of Experimental group and control group on retention test. Secondary school students studying mathematics constituted the population of study. The student of 10th class of Govt. Pakistan Girls Higher School, Rawalpindi (Pakistan) was selected as a sample of the study. The pre-test post-test equivalent- group design was used for the study. The sample size consisted of forty eight students who were divided into experimental group and control group, each consisting of 24 students by equating them on their previous knowledge in mathematics, as determined through a pre-test. A treatment of planned problem-solving approach was provided to the experimental group while the control group was taught by expository strategy for a period of six weeks.