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Home > Effects of Different Preparations of Nigella Sativa Ns on Glucose and Lipid Metabolism in Type Ii Diabetic Patients

Effects of Different Preparations of Nigella Sativa Ns on Glucose and Lipid Metabolism in Type Ii Diabetic Patients

Thesis Info

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External Link

Author

Bilal, Ahmad

Program

PhD

Institute

Pir Mehr Ali Shah Arid Agriculture University

City

Rawalpindi

Province

Punjab

Country

Pakistan

Thesis Completing Year

2008

Thesis Completion Status

Completed

Subject

Applied Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/497

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726019259

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The basic aim of this placebo control study was to investigate the effects of three different preparations of Nigella sativa especially on glucose and lipid metabolism in type 2 diabetes mellitus (DM2) patients (group-A); however normal individuals (group- B) was also studied. Both groups were treated with N. sativa Seed Powder (NsP), N. sativa Aqueous Extract (NsE) and N. sativa Oil (NsO), in addition to a placebo in phases 1, 2 and 3 respectively. Each phase was of 80 days (40 days of treatment with N. sativa preparation followed by 40 days of placebo administration). Levels of 0 day were taken as base line (concurrent control) in each phase. Fasting blood levels of glucose, insulin, total cholesterol (TC), LDL & HDL cholesterols, triglycerides (TG), total leukocyte & platelet counts, hepatic profile and blood urea were determined in subjects of both groups on 0, 40 and 80 th day of each phase of the study. In phase-1 a highly significant fall in fasting blood glucose, TC, LDL cholesterol and TG while an increase in insulin and HDL was observed in group-A after treatment with NsP as compared to concurrent control. These levels significantly reversed at the end of placebo except the HDL cholesterol. Almost similar results were obtained in subjects of group-B. In phase-2 although a decrease in glucose and increase in insulin levels was observed in group-A after treatment with NsE; which reversed after the placebo yet the changes were not significant. However a significant fall was observed in TC and TG levels of diabetics after NsE treatment; which reversed after the placebo significantly in TG but insignificantly in TC. In group B, results regarding glucose and insulin levels were similar to that of group-A of this phase. Concerning lipid profile, a significant fall in TG and insignificant decrease in TC and LDL cholesterol was observed after NsE treatment. The changes reversed after the placebo, significantly in TG and LDL cholesterol but insignificantly in TC. In phase-3, a significant fall in fasting blood glucose and a rise in insulin levels was observed in group-A after treatment with NsO2 as compared to concurrent control levels. A significant decrease in LDL & increase in HDL was observed while TC remained statistically unchanged; however a significant increase was also recorded in TG after NsO treatment. LDL and TG levels reversed significantly, while no significant change was observed in HDL and TC levels after the placebo. Subjects of group-B behaved similar to group-A, as for glucose and insulin are concerned. Regarding lipids, a decrease in LDL cholesterol (significant) and TC (insignificant) while increase in HDL cholesterol and TG (insignificant) was observed in group-B after the use of NsO. LDL and TC increased significantly after the placebo while no significant change was recorded in HDL cholesterol and TG. Total leukocyte and platelet counts remained statistically unchanged in both groups A and B, when treated with NsP, NsE, NsO or administered with placeboes in phases 1, 2 and 3 respectively as compared to their base line levels Similarly no unpleasant effect of any of the N. sativa preparation was observed regarding hepatic profile, blood urea and the subjective feelings of the diabetic and normal individuals. In the light of foregoing facts it can safely be concluded that all preparations of N. sativa had some or more antidiabetic effect. However keeping in view the overall performance, NsP was found more effective. Further large scale human studies with different dose schedules of NsP are recommended.
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ڈاکٹر محمد طاہر

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یکم جنوری کو ۸ بجے شب دارالمصنفین کے ایک بڑے ہمدرد اور ہر وقت کے حاضر باش ڈاکٹر محمد طاہر صدر شعبۂ اردو شبلی نیشنل پوسٹ گریجویٹ کالج انتقال کرگئے، ابھی ان کی عمر ۵۰ برس ہی کی رہی ہوگی لیکن انہوں نے اپنی صلاحیت و ذہانت کے جو نمونے چھوڑے وہ برابر یاد کئے جائیں گے، انہیں تحریر وتقریر دونوں کا ملکہ تھا، پہلی مرتبہ علامہ شبلی کی تاریخِ ولادت کا تعین اپنے ایک مضمون میں کیا جو ’’نیا دور‘‘ لکھنؤ میں شائع ہوا، مگر ان کی زیادہ توجہ انتظامی امور کی طرف ہو گئی تھی جس کا انہیں بہت اچھا سلیقہ تھا، اب ان کی سر گرمیوں کا خاص میدان سرسید انٹر کالج صبرحد تھا جس کو پہلے ہائی اسکول اور پھر انٹر کالج بنوایا، اسے ڈگری کالج بنانے کے لئے جان توڑ کوشش کررہے تھے کہ وقتِ موعود آگیا، دارالمصنفین کے ہر کام میں آگے آگے رہتے تھے، اسلام اور مستشرقین کے موضوع پر یہاں ہونے والے بین الاقوامی سیمینار کے شرکاء کے طعام کی ذمہ داری جس حسن و خوبی سے انجام دی اس کا اعتراف جناب سید صباح الدین عبدالرحمن مرحوم برابر کرتے تھے، ان سے اور شاہ معین الدین احمد ندوی مرحوم کے علاوہ اس خاکسار سے بڑا مخلصانہ تعلق رکھتے تھے، اﷲتعالیٰ ان کی بشری لغزشوں کو معاف کرے اور ان کی مغفرت فرمائے اور ان کے اعزہ خصوصاً بیوہ اور دونوں کم سن بچوں کو صبرِ جمیل عطا فرمائے۔ آمین! (ضیاء الدین اصلاحی، جنوری ۱۹۹۶ء)

 

شخصية الصحابة في شعر صدر الإسلام

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Wavelets and Radial Basis Functions in Scienti C Computing

The present work is an application of wavelets and radial basis functions to numerical computing. More specifically, we have used Haar and Legendre wavelet for applications of wavelets and multiquadric for applications of radial basis functions. The application areas considered in this thesis are the numerical solution of Integral Equations (IEs), various order Integrodifferential Equations (IDEs), systems of IEs, Elliptic Partial Differential Equations (EPDEs), Parabolic Partial Differential Equations (PPDEs) and highly oscillatory integrals. A few theoretical results are proved for efficient evaluation of some particular systems that arise when we apply one- or two-dimensional Haar wavelet in the wavelet collocation method. Based on these theoretical results new numerical methods based on Haar wavelet are developed for solution of IEs, IDEs and systems of IEs. EPDEs are solved numerically using collocation methods with Haar and Legendre wavelet. Legendre wavelet is also applied for the numerical solution of PPDEs. A new method based on multiquadric radial basis functions is introduced for numerical solution of highly oscillatory integrals. While applying Haar wavelet to numerical solution of IEs we have considered both nonlinear Fredholm and nonlinear Volterra IEs of the second kind. Similarly in case of IDEs a Haar wavelet based method is applied to find numerical solution of first and higher orders nonlinear Fredholm and nonlinear Volterra IDEs. The main advantage of this method is that it is generic as it can be applied to IEs, IDEs and systems of IEs. More specifically the new approach aims at the numerical solution of Fredholm, Volterra and Volterra-Fredholm types of IEs, IDEs and IDEs of higher orders including initial- as well as boundary-value problems. With a slight modification the method can also be applied to find numerical solution of two-dimensional IEs, system of IDEs and partial IDEs. Another distinguishing feature of themethod is that unlike many other existing methods in the literature it does not use any intermediate technique for numerical integration of the kernel function in IEs or IDEs. We have developed two new types of collocation methods based on Haar wavelet and Legendre wavelet for numerical solution of EPDEs. A modification of the collocation method based on Haar wavelet for elliptic differential equations is also introduced that improves the efficiency of the method. The collocation method based on Legendre wavelet is extended to find numerical solution of PPDEs. An advantage of the proposed methods is that it can be applied to different types of boundary conditions (BCs) with slight modifications. For highly oscillatory multidimensional integrals a new Levin’s type method based on multiquadric radial basis functions is developed. Levin method converts the numerical integration problem of highly oscillatory multidimensional integral to a PDE which is subsequently solved using meshless method. The proposed methods are validated on a variety of problems as well as numerical results of the proposed methods are compared with several existing methods from the literature. The numerical results show better performance of the proposed methods for several benchmark problems.