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Home > Electrochemical Study of Metal Complexes of Active Ingredient of Nigella Sativa Black Seed

Electrochemical Study of Metal Complexes of Active Ingredient of Nigella Sativa Black Seed

Thesis Info

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Author

Kishwar, Farah

Program

PhD

Institute

Federal Urdu University of Arts, Science and Technology

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2013

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/947

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726045570

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Nigella sativa (Kalongi) seeds are well-known for the improvement of human health and used as folk medicine in treatment of various ailments. This is because of the fact that the seeds are a good source of several essential macro and micro nutrients as well as of many biologically active compounds. In present work electrochemical study of thymoquinone, which is the main active constituent of the N. sativa seed, was done using cyclic voltammetric technique at glassy carbon electrode versus saturated calomel electrode. Through cyclic voltammetry different quantitative and qualitative characteristics of Fe(III)-Thymoquinone complex, Cr(VI)-Thymoquinone complex, Cu(II)-Thymoquinone complex and Co(II)-Thymoquinone complex were determined. In all cases NaCl was used as supporting electrolyte except Cu(II)-Thymoquinone complex where LiCl was also used. The results showed quasi-reversible electron transfer reaction for all above mentioned complexes; however, in case of Cu(II)-Thymoquinone complex a shift from quasi-reversible to reversible behavior was observed. Effect of various parameters, such as scan rate, concentration and metal ligand ratio on complexes was noted by varying any one of them at one time while keeping others constant. Effect of repeated scanning was also examined. Results revealed presence of pre equilibrium charge transfer process in cases of Cr(VI)-Thymoquinone complex, Co(II)-Thymoquinone complex and Cu(II)-Thymoquinone complex, whereas post equilibrium charge transfer process in Fe(III)-Thymoquinone complex. The quantitative study with cyclic voltammetry showed that the use of a glassy carbon electrode could be helpful to quantify these complexes (Fe(III)-Thymoquinone complex and Co(II)- Thymoquinone complex 2 x 10 -5 to 1.2 x 10 -3 M, Cr(VI)-Thymoquinone complex 2 x 10 -4 to 1.2 x 10 -3 M and Cu(II)-Thymoquinone complex 2 x 10 -4 to 1.6 x 10 -3 M ). Hence this method can be used in the pharmaceutical quality control assay of these complexes. Values of transfer coefficient α and β, diffusion coefficient and E ̊ were also calculated for each complex. In addition, electrochemical study of V(IV)-Thymoquinone complex and Fe(III)-Thymol complex, Cr(VI)-Thymol complex, Cu(II)-Thymol complex, V(IV)-Thymol complex and Co(II)-Thymol complex was also performed which was not done in detail due to lack of time and facilities. Thymol is another active constituent of the black seed. Results indicated that cyclic voltammetry could also be helpful for determination of various quantitative and qualitative parameters of this constituent and its complexes. VIBefore performing electrochemical study some physical properties of the black seed were determined including moisture content and dissolved (DS) and undissolved solid (UDS) contents of the seed. Comparison of the results obtained for DS and UDS in aqueous and acidic medium showed that fast absorption of the seeds may take place in the acidic environment of stomach. The seed was also examined for its elemental composition using scanning electron microscopy which showed presence of several essential macro as well as micro elements in the seed. In order to find out suitable pH for complex formation, complexation of thymoquinone and thymol with Fe(III), Cr(VI), Cu(II), V(IV) and Co(II) was also investigated by pH-metry. Results revealed that out of above mentioned metals Fe(III) and V(IV) forms relatively stable complexes with both ligands. Moreover, they formed complexes at low pH while rest of the metals at high pH. Comparison of thymol and thymoquinone complexes indicates that thymoquinone forms more stable complexes with all mentioned metals as compared to thymol. pK a of both ligands was also determined. Present research also reveals that in case of heavy metal toxicity (specially by Fe(III), Cr(VI), Cu(II), V(IV) and Co(II)) thymoquinone and thymol could be helpful to remove them from the body. As both of the compounds form complexes with all above mentioned metals, they can be used in chelation therapy to remove toxic metals. It is also possible that both thymoquinone and thymol being antioxidants could reduce these metals, for example Fe (III) to Fe (II), Cr (VI) to Cr (III) etc. and hence converting these metals into their reduced form which is beneficial for the human body.
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المبحث الأول: بداية الشعر الحر

المبحث الأول: بداية الشعر الحر

نُشِرت قصیدۃ ’’الکولیرا‘‘ في بیروت ووصلت نسختھا ببغداد في أول کانون الأول عام 1947م وفي النصف الثاني من الشھر نفسہ صدر دیوان بدر شاکر السیّاب (أزھار ذابلۃ) في بغداد، تقول نازک بأن في ھذا الدیوان قصیدۃ حرۃ الوزن ولہ في بحر الرمل عنواناً (ھل کان حباً) ولکن علق علی ھذہ القصیدۃ في الحاشیۃ بأنھا من "الشعر مختلف الأوزان والقوافي" وھذا النموذج منھا :


 ھل یکون الحبّ أني
 بتّ[1] عبداً للتمني
 أم ھو الحب أطراح الأمنیات
 والتقاء الثغر بالثغر ونسیان الحیاۃ
 واختفاء العین في العین انتشاء
 کانثیال عاد یفني في ھدیر
 أو کظل في غدیر[2]

ثم وضحت الشاعرہ نازک الملائکۃ في قضایا الشعر المعاصر بأن ظھور قصیدۃ (الکولیرا) و (ھل کان حباً) لم یلفت نظر الجمھور والقراء؛ ولکن حصل تعلیق واحد فقط في مجلۃ (العروبۃ) علی أسلوب ووزن قصیدۃ (الکولیرا) ولکن مضت سنتان لم یکتب أحد شعراً حراً ولا تعلیقاً آخر علی الشعر الحر۔ ولکن عندما ظھر دیوان نازک الملائکۃ (شظایا ورماد) عام 1949م قامت ضجۃ شدیدۃ في صحف العراق ومناقشات في الأوساط الأدبیۃ، فبعضھم تنبأوا لھذہ الدعوۃ الجدیدۃ بالفشل وبعضھم تشجعوا واستجابوا لہ۔



[1] بتّ ، مأخوذ من بات والمقصود قضى الليل

[2] الملائکۃ، نازک، قضایا الشعر المعاصر(بیروت، لبنان: دار العلم للملایین) الطبعۃ الثانیۃ عشرۃ، 
ینایر 2004م، ص36 ۔

ہماری دینی ترجیحات، ایک لمحہ فکریہ

If the determining of religious priorities is correct then religion also remains in its original state and the effects of religion also appear clear and conspicuous and if the priorities go wrong, then humanity goes far beyond the actual religion. And the attitudes of the religious oriented people also become a source of doubts regarding religion. And the low regard of religious personality also leads to the disgrace of the religion. Before we take a deep look at our religious priorities, it is important to understand that what is the importance of priorities in life and what is meant by religious priorities.

F Ormulation of a S Trategy for U P - Gradation of the I Ndustrial T Echnology in P Akistan

Poor performance in manufacturing in Pakistan is due to technological obsolescence, low level of technological capabilities and poor technology climate. Development of such capabilities will not occur if left to market forces alone and will only be possible through the formulation and implementation of an up-gradation strategy based on strategic framework. This research, therefore establishes the need for such a strategy based on framework for up-gradation of industrial technology in Pakistan. Such strategy also stresses the need for Pakistan’s economy to also include within it important structural changes which other developing countries and newly industrialized countries have already embraced. In this regard the research highlights the need for Pakistan’s industrial sector to focus more on Medium, High Tech and R&D based manufactures. This research has also identified the targeted sectors using porter’s diamond analysis tool. The targeted sectors include; Low Technology (Ceramics), medium Technology Engineering (Automobile) and high Technology (Electronics) industries. Identification and critical analysis of various technological capabilities and supportive technology climate based on the targeted sectors, universities and R & D institutions in Pakistan has been carried out. Strategic framework based on three perspectives, each with three elements, representing technological capabilities and supportive technology climate has been established in this research. The framework includes; Indigenous Technology Development Perspective Elements 1: General technology status / competence level capability of targeted sector/industry. Element 2: Linkage (Collaboration) Capability among the various technology using, creating Sand governing institutions. Element 3: Research/Innovative Capability (Technology creating capability) such as universities and R&D Institutions. Import of Foreign Technology Perspective Element 4: Technology Acquisition Capability xivElement 5: Technology Assimilations Capability Element 6: Technology Improvement Capability Supportive Technology Climate Perspective Element 7: Supportive Organizational Environment Element 8: Supportive Management Style Element 9: Supportive Government Role. Further research explores the need for Pakistan to develop all such capabilities. Empirical evidence on general technological status/ competence level, research/innovative capability, linkages capability and similarly on acquisition, assimilation and improvement capabilities indicators substantiated the claim that Pakistan has not yet developed these advance capabilities. In order to facilitate the capabilities building process, it is imperative for Pakistan to have in place an intelligent strategic framework followed by supportive technology institutional framework based on the strategy formulated in this research. The need for a supportive (fostering) technology climate to act as an enabling environment for the entire exercise in this research is also stressed. Whereas the empirical evidence indicates that the organizational environment in industries, universities and R&D institutions is highly individualistic, less ethical, hostile and run on corrupt practices. Similarly the management style is highly centralized, unparticipative, personalized and does not govern on established procedures. The evidence further explore that the government role is extremely unsupportive, dictatorial, obstructionist and does not play guiding and leading role for intelligent policy formulation and implementation. Based on the need establishment and strategic framework, recommendations and strategic directions for up-gradation of all capabilities along with supportive technology climate identified in the framework have been made in this research. Moreover, some macro-political, economic and cultural factors with special reference to developing countries and it implication for Pakistan has also been identified and deliberated, which influence this entire technology up-gradation exercise. The benefit of the up-gradation strategy based on strategic framework are established through a case study of an existing automotive vendor industry in Lahore, Pakistan, anticipating focused and sustained approach compared to string of random and undirected intervention for technology up-gradation in the past.