Hepatitis B virus (HBV) and hepatitis C virus (HCV) exerts an intense impact on patient’s lipid metabolism. Hence the aim of present study is to determine metabolic derangement that occurs in subjects suffering from hepatitis B, C and cirrhosis. The fasting blood samples were collected from hepatitis B (n=50), C (n=50) and cirrhosis patients (HBV-cirrhosis n=30 and HCV-cirrhosis n=50) along with age and gender matched controls. After separating serum, lipid profile was analyzed by micro-lab 300 and fatty acids (FAs) composition was examined by gas chromatography. Fatty acids were further confirmed by gas GC-MS technique. The epidemiological risk factors for transmission of HBV, HCV and cirrhosis were measured through standard questionnaire specially designed for that purpose. The demographic factors, mainly positive family history, dental treatment, blood transfusion and shaving from barber shop are significant contributing factors in spread of HBV, HCV, and cirrhosis infection. Hypolipidemia in HBV and HCV patients is possibly due to alter liver function. Lipogenesis is elevated in HCV and HBV patients as evident from reduced serum PUFA and elevated SFA as well as MUFA levels. Hence, it proposes the importance of PUFA supplementation and it may provide synergistic antiviral effects when given as a food supplement during the INF based anti - HCV therapy. The lower level of lipid profile (TAG, cholesterol, LDL–C, HDL–C, VLDL–C and total lipids) indicating hypolipidemia in HBV-cirrhosis and HCVcirrhosis patients specify the nonfunctioning of liver. The increased lipogenesis (increased level of SFA) and reduced PUFA levels may be due to altering desaturases activities, impaired PUFA metabolism and non-enzymatic oxidation is associated with progression of HBV-cirrhosis/ HCV-cirrhosis diseases in patients and promote the hepatic lipotoxicity. In conclusion, the hepatitis B and C viruses alter the total cholesterol and FA metabolic pathways. Therefore, the present study provides the information about the changes associated with lipid metabolism and significant upregulation, which might be used as a biomarker for hepatitis B, C and cirrhosis diseases.
درخت کم تھے، آبادی زیادہ اور ہوا اِس قدر آلودہ تھی کہ لوگ سانس لینے کی خاطر آکسیجن سلینڈر اپنے ساتھ رکھتے۔۔۔جگہ جگہ آکسیجن اسٹیشن بن گئے تھے جہاں لوگ لمبی قطاروں میں اپنی اپنی باری کا انتظار کرتے رہتے۔۔۔بڑی بڑی کمپنیاں دن رات اپنے اشتہارات تقسیم کرتی رہتیں کہ اگر اپنے پھیپھڑوں کو تندرست وتوانا رکھنا چاہتے ہیں تو اُن کی کمپنی کا آکسیجن سلینڈرحاصل کریں،اگرچہ فضا میں آکسیجن اب بھی موجود تھی لیکن اِن کمپنیوں نے جدید تحقیق سے یہ ثابت کر دیا تھا کہ اب بغیر آکسیجن ماسک کے سانس لینا زندگی کے لیے خطرہ ہے سو لوگ سانس لیتے ہوئے گھبرانے لگے۔
آکسیجن کی تقسیم میں بھی طبقاتی نظام رائج تھا، طاقتور کو زیادہ اور آسانی سے آکسیجن دستیاب تھی بلکہ اُنہیں کبھی بھی آکسیجن حاصل کرنے کی خاطر قطار میں نہ کھڑا ہونا پڑتا اور ابھی اُن کے گھروں کے سٹور روم میں کئی سلینڈر پڑے ہوتے کہ نئی کھیپ اُن کے دروازے پر پہنچ جاتی یہی وجہ تھی کہ اُن لوگوں نے کئی کئی سالوں کی ایڈوانس آکسیجن جمع کر رکھی تھی۔۔۔غریب لوگ اپنے پرانے سلینڈر ہاتھوں میں لیے قطار میں کھڑے رہتے، بہت سے لوگ دم گھٹنے کی وجہ جان کی بازی ہار جاتے۔۔اُن کے عزیز رشتہ دار سڑک بند کرکے احتجاج کرتے لیکن طاقتور طبقہ ہمیشہ یہی کہتا کہ ہمیں تمہارے دکھوں کا پوری طرح احساس ہے، جلد کوئی حل نکالتے ہیں، سڑک کھول دو۔۔۔سڑک کھل جاتی لیکن حل نہ نکلتا حتٰی کہ کوئی اور آدمی دم گھٹنے سے ہلاک ہو جاتا۔۔۔۔۔
Islam is universal Religion which not only clear with issues related to Muslims but also clarify the rules and regulations to have intinary with Non-Muslims. Islam emphasizes on primary/ basic rules about relationship of Muslims and Non- Muslims Communities; justice, peace, mutual harmony and co-operation. No force conversion and freedom of thought, Non compulsion Of impartiality convenant. Islam forces on mutual existence in according of these rules. So, clash of civilizations can be avoided in the present age.
The study of thin liquid film flow is equally critical for engineers, mathematicians and physicists. The engineering revolution core is expended by the impacts of lubrication and microelectronics industry. In general, thin liquid film flow occurs widely in nature and also in various industrial processes namely, thin liquid films are encountered in any lubrication problem (lubricating gears, bearings, metered coating, cold rolling of steel), in microelectronics industry (manufacture of CDs, DVDs, screen, electronic circuit, microelectronics chips and computer disks), in printing technology (drop spreading process), in heat and mass transfer devices (spinning disk reactors and distillation columns) to limit fluxes and to protect surfaces etc. In this research the attention has been given to the analysis of theocratical investigation of magnetohydrodynamics flows over an unsteady stretching sheet. Non-dimensional scaling are used for the governing equations with finite boundary conditions to transform into their dimensionless form. Different physical effects are involved in the respective problems, to observed the effects on the boundary layer flows. Similarly different types of fluid are investigated for the MHD unsteady thin film flow such as Newtonian fluid, non-Newtonian fluids (second grade fluids, Casson fluid and nanofluids). Magnetic field is normal to the direction of flow in all the respective problems. Effects for various physical parameters are investigated in the form of tables and figures. HAM and BVP4C are used for the solutions of the problems.