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Ferrocenyl Amides, Promising Materials for Certain Potential Applications

Thesis Info

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Author

Nigar, Asifa

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/1662

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726204384

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Some ferrocenyl amides were synthesized by the solution phase condensation reaction of 4-ferrocenyl benzoyl chloride and 4-ferrocenyl aniline with organic amine and acid chloride derivatives respectively. A series of semi aromatic amine derivatives with variable alkyl chain at one end was prepared in a three step process which was condensed with 4-ferrocenyl benzoyl chloride resulting in the formation of ferrocene derivatives with two amide bonds. Another series with a single amide bond was prepared by the condensation of 4-ferrocenyl aniline with n-alkyl acid chloride derivatives of different chain length. The third series of ferrocenyl amides was synthesized by the reaction of 4-alkoxy benzoyl chloride and 4-ferrocenyl aniline to get seven compounds with variable alkoxy chain. The fourth and final series was prepared by using 4-(4- alkoxy phenyl) benzoyl chloride derivative to condense with 4-ferrocenyl aniline and five products bearing different alkoxy end groups were obtained. All the synthesized compounds were characterized by their physical properties, elemental analysis, FTIR and 1 H/ 13 CNMR spectroscopic techniques for the structure elucidation. The crystals of some organic intermediates were also developed and studied for the single crystal XRD structural factors. A strong intermolecular H-bonding was confirmed for the secondary amide groups present within all the molecules of the intermediates and final products by spectroscopic and XRD techniques. These secondary types of forces are pre-requisite for a compound to interact with the bio molecules such as DNA by developing some intermolecular forces between the two. Therefore, the synthesized nitroaromatic compounds and their amine derivatives along with ferrocenyl amides were studied for the DNA-binding properties by using UV visible spectroscopic and cyclic voltammetric techniques. The DNA-interactional behaviour of organic intermediates was also supported by the docking studies leading to the conformation of bonding modes that are accessible. Ferrocenyl amides and nitroaromatic compounds were investigated for their electrochemical properties and the redox mechanism involved for the both was suggested using cyclic voltammetric methods. The melting point behavior of the synthesized materials was also depictive of their mesomorphic nature, so the selected compounds were studied for the metallomesogenic properties using DSC and POM techniques. The phase transition temperatures and the heat changes associated with different transitions were evaluated for the thermodynamic behavior of the materials and texture of the iiiAbstract mesophases were studied by POM at different temperatures. The thermotropic liquid crystalline nature of the synthesized compounds was found to have some relationship with the structure of molecules which was further evaluated by the theoretical calculations of the rigid and flexible part lengths of molecules by using PM6 method. The effect of alkyl and alkoxy chain lengths on the electrochemical, DNA-binding and liquid crystalline properties were studied in detail and found to influence the properties in following order; liquid crystalline > electrochemical > DNA-binding properties. In fact, it has no effect on DNA-binding strength as alkyl chain is not being actively involved in the binding process.
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ترجمہ کی اصطلاحات

ترجمہ کی اصطلاحات
ٹارگٹ لینگوئج:
وہ زبان جس میں ترجمہ کیا جارہا ہے۔
سورس لینگوئج:
اصل زبان جس سے متن لیا جارہاہے۔
مثال:
میاں محمدبخش کی سیف الملوک پنجابی میں ہے تو اس کی سورس لینگوئج پنجابی ہے اور اگر اسے اردو میں ترجمہ کرنا ہے تو ٹارگٹ لینگوئج اردو ہے۔
ٹرانسلیٹریشن:Transliteration
زبان وہی ہو اور رسم الخط دوسرا ہو۔
ٹرانس میوٹیشن Transmutation :
زبان کو کسی نظام کی شکل دینا۔ جیسے تحریری طور پر لکھا ہو کہ سگریٹ نوشی منع ہے تو اس کو تصویری نظام کے ذریعے سے ظاہر کرنا
ٹرانسکرپشن Transcription :
مخصوص اشاروں سے صوتی، معنوی اور لفظی جہت کو ظاہر کرنا
ترجمہ نگاری کے اصول:
• ترجمہ نگار کو ٹارگٹ لینگوئج اور سورس لینگوئج کے بارے میں آگاہی ہونی چاہیئے۔
• دونوں زبانوں کے تلفظ اور معانی سے آشنائی ہونی چاہیئے۔
• دونوں زبانوں کے رموز واوقاف کا پتہ ہونا چاہیئے۔
• دونوں زبانوں کی اصطلاحات سے واقفیت ضروری ہے۔
• دونوں زبانوں کے محاورات اور ضرب الامثال سے واقفیت رکھنا ضروری ہے۔
• اصل مفہوم پہنچانے کی کوشش کرنی چاہیئے۔
• سیاق و سباق اور مصنف کے مزاج کو سامنے رکھنا بہت ضروری ہے۔
٭٭٭٭٭٭

EFFECT OF STATIC STRETCHING OF HAMSTRING ON NON-SPECIFIC LOW BACK PAIN

Objective: To determine the effect of static stretching of hamstring muscle on the non-specific low back pain. Methodology: A Quasi-Experimental study was conducted in Rabia Moon Institute of Neurology which total 30 participants were included through non-probability purposive sampling. Thirty participants were selected who fulfilled our inclusion criteria, they were divided into two groups; group A or treatment group received conventional physiotherapy treatment as well a static stretching exercise protocol for 5 days. Group B or control group received conventional physiotherapy treatment only. VAS (Visual analog scale) and Oswestry Disability questionnaire, SFGD (Standing Finger to ground Distance,) PSLR (passive straight leg raise) for both legs were measured pre- and post-treatment. Result: A total of 30 patients aged 20-55 were included in the study. Mean age of the participants was found to be 37.88 years.  The difference in means of all the assessment parameters pre and post-treatment for both groups were analyzed through paired t-test. There was a significant improvement in VAS, SFGD, Passive Straight leg Raise PSLR (right leg), PSLR (left leg) and level of disability pre- and post-treatment in the treatment group. Conclusion: This present study concluded that static stretching of hamstrings is effective in decreasing non-specific low back pain.

Modified Optical Properties of Au Embedded Wide Band Gap Semiconductor Thin Films and Nanostructures

Wide bandgap semiconductors provide efficient absorption in UV and very low absorptions in the visible range of the electromagnetic spectrum. This limits their effectiveness in photocatalytic, photoactive and photosensitive devices. However, the optical properties of these semiconductors can be enhanced to provide increased absorptions in the visible range. The bandgap of the semiconductor can be modulated in several ways that include: doping, formation of heterostructures, quantum dots coupling, addition of metallic nanoparticles etc. In the present work, the surface plasmon resonance (SPR) energy of Au is utilized in three different semiconductor morphologies to tune the optical characteristics. Studies with three different dielectric environments such as: Au embedded planar, non-planar and Au coated wide bandgap semiconductors were performed. Specific studies of metal sandwiched planar (TiO2/Au/TiO2), heterostructure (ZnO/Au/TiO2) and Au coated ZnS nanostructures using various optical techniques that included spectroscopic ellipsometry, UV/Vis absorption and photoluminescence spectroscopy (PL) were performed in this work. The UV/Vis absorptions of TiO2/Au/TiO2 revealed the presence of two broad bands in the visible range, that were absent in TiO2 thin film, for both as-grown and annealed samples. This was attributed due to improved interband and plasmon resonance oscillations of Au in a dielectric environment. Spectroscopic ellipsometry of the Au, TiO2 and composite TiO2/Au/TiO2 films indicated that they carried the cumulative effect of UV and visible absorptions due to SPR phenomenon. The presence of interband transition was confirmed by fitting the experiment with the theoretical models, Tauc Lorentz model and Drude Lorentz model for TiO2 and Au, respectively. Dielectric functions obtained from ellipsometry were combined for the sandwiched structure using effective medium approximation (EMA) methods. The modelling showed the presence of interband transitions which provide improved absorption at Au/TiO2 interface. The values of Urbach energy which corresponds to TiO2 band tails extended into the visible region was also estimated. The increase in Urbach energy was xi a direct consequence of coupling of plasmons with the defect induced TiO2 band tail widened into the visible range. The effect of metal nanoparticles was observed in ZnO/Au/TiO2 nanoheterostructures in UV/Vis absorption and PL spectroscopy. The Au content embedded in the ZnO/Au/TiO2 composite was varied from 2-10 nm. It was observed that maximum absorptions in the structure occurred when Au content was varied to 6 nm (corresponding to the diameter of 9.8 ± 3.5 nm and density 1.4 x 1011 cm-2).Photoluminescence spectroscopy also revealed the maximum pinning of the defect states in TiO2 interface at 6 nm due to maximum participation of hot electrons injected through the SPR phenomenon. This study also highlighted the importance of dielectric layer and thickness surrounding the NPs as it affected the spread of Au NPs SPs resonant field. The third study comprised of the temperature dependent photoluminescence of ZnS nanostructures doped with two different elements, Mn and Sn. The defect centres in ZnS nanostructures provide very high luminescence. The coupling of these luminescent centres with the Au NPs altered the luminescence dynamics by introducing new charge transfer paths. In the present study, the overlapping of the Mn-induced defects with the SPR peak of Au resulted in quenching of UV peak corresponding to donor-acceptor transitions. While the Mn-induced defect overlapping the Au plasmon field was still present. Likewise, the presence of Au not only affected the defect-based transitions due to different ionic species in Sn-doped ZnS nanostructures but also activated the resonant processes in Sn, which is a semi-metal itself.